Opinion: Addressing systemic problems in the biomedical research enterprise

Last spring, the four of us published an essay in PNAS in which we described the severe problems now faced by scientists working in the US biomedical research system, recommending several steps that might be taken to improve the situation (1). As a follow up, we convened a two-day workshop in August that brought together 30 relatively senior individuals engaged in various aspects of biomedical science, including social scientists and others who are knowledgeable about the training pipeline.