The ubiquity of pleiotropy in human disease

[1]  Michael J. E. Sternberg,et al.  Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights , 2017, Human mutation.

[2]  P. Visscher,et al.  A plethora of pleiotropy across complex traits , 2016, Nature Genetics.

[3]  Qian Wang,et al.  Implications of pleiotropy: challenges and opportunities for mining Big Data in biomedicine , 2015, Front. Genet..

[4]  Joseph K. Pickrell,et al.  Detection and interpretation of shared genetic influences on 42 human traits , 2015, Nature Genetics.

[5]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[6]  Hongyu Zhao,et al.  GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation , 2014, PLoS genetics.

[7]  A. Butte,et al.  Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records , 2014, Science Translational Medicine.

[8]  Peggy Hall,et al.  The NHGRI GWAS Catalog, a curated resource of SNP-trait associations , 2013, Nucleic Acids Res..

[9]  S. Purcell,et al.  Pleiotropy in complex traits: challenges and strategies , 2013, Nature Reviews Genetics.

[10]  Hongyu Zhao,et al.  Improving genetic risk prediction by leveraging pleiotropy , 2013, Human Genetics.

[11]  Marylyn D. Ritchie,et al.  Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network , 2013, PLoS genetics.

[12]  Sang Hong Lee,et al.  Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood , 2012, Bioinform..

[13]  W. G. Hill,et al.  On the Pleiotropic Structure of the Genotype–Phenotype Map and the Evolvability of Complex Organisms , 2012, Genetics.

[14]  P. Visscher,et al.  Five years of GWAS discovery. , 2012, American journal of human genetics.

[15]  F. Agakov,et al.  Abundant pleiotropy in human complex diseases and traits. , 2011, American journal of human genetics.

[16]  G. Wagner,et al.  The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms , 2011, Nature Reviews Genetics.

[17]  Frank W. Stearns One Hundred Years of Pleiotropy: A Retrospective , 2010, Genetics.

[18]  Jianzhi Zhang,et al.  Genomic patterns of pleiotropy and the evolution of complexity , 2010, Proceedings of the National Academy of Sciences.

[19]  Scott M. Williams,et al.  Shadows of complexity: what biological networks reveal about epistasis and pleiotropy , 2009, BioEssays : news and reviews in molecular, cellular and developmental biology.

[20]  G. Wagner,et al.  Pleiotropic scaling of gene effects and the ‘cost of complexity’ , 2008, Nature.

[21]  Sterling Sawaya,et al.  THE GENETICS OF ADAPTIVE SHAPE SHIFT IN STICKLEBACK: PLEIOTROPY AND EFFECT SIZE , 2007, Evolution; international journal of organic evolution.

[22]  A. Rzhetsky,et al.  Probing genetic overlap among complex human phenotypes , 2007, Proceedings of the National Academy of Sciences.