Bone morphogenetic protein (BMP)-6 and BMP-7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 MAPK activation

ActRI and ActRII, activin type I and type II receptor ALK, activin receptor-like kinase Arom, aromatase BMP, bone morphogenetic protein BMPRI and BMPRII, BMP type I and type II receptor ER, estrogen receptor ERK, extracellular signal-regulated kinase MAPK, mitogen-activated protein kinase SAPK/JNK, stress-activated protein kinase / c-Jun NH2-terminal kinase TGF-β, transforming growth factor-β Page 1 of 44 Accepted Preprint first posted on 9 September 2008 as Manuscript JOE-08-0226

[1]  K. Mokbel,et al.  Oestrogen producing enzymes and mammary carcinogenesis: a review , 2008, Breast Cancer Research and Treatment.

[2]  F. Otsuka,et al.  Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. , 2008, The Journal of endocrinology.

[3]  Foster Pa Steroid metabolism in breast cancer. , 2008, Minerva endocrinologica.

[4]  F. Otsuka,et al.  Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. , 2007, American journal of physiology. Renal physiology.

[5]  M. Shupnik Estrogen receptor-β: why may it influence clinical outcome in estrogen receptor-α positive breast cancer? , 2007, Breast Cancer Research.

[6]  K. Watabe,et al.  Roles of AKT signal in breast cancer. , 2007, Frontiers in bioscience : a journal and virtual library.

[7]  B. Potter,et al.  Steroid sulfatase: a new target for the endocrine therapy of breast cancer. , 2007, The oncologist.

[8]  W. Muller,et al.  The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer , 2007, Oncogene.

[9]  F. Otsuka,et al.  Regulatory expression of bone morphogenetic protein-6 system in aldosterone production by human adrenocortical cells , 2007, Regulatory Peptides.

[10]  J. Stenvang,et al.  A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer , 2007, Breast Cancer Research and Treatment.

[11]  F. Otsuka,et al.  Mutual Regulation of Follicle-Stimulating Hormone Signaling and Bone Morphogenetic Protein System in Human Granulosa Cells1 , 2006, Biology of reproduction.

[12]  P. Kauraniemi,et al.  Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer , 2006, Genes, chromosomes & cancer.

[13]  F. Otsuka,et al.  Regulatory roles of bone morphogenetic proteins and glucocorticoids in catecholamine production by rat pheochromocytoma cells. , 2005, Endocrinology.

[14]  Horst Buerger,et al.  First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor‐positive breast cancer , 2005, The Journal of pathology.

[15]  A. Pardee,et al.  Crossroads of Estrogen Receptor and NF-κB Signaling , 2005, Science's STKE.

[16]  A. Harris,et al.  Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. , 2005, International journal of oncology.

[17]  H. Doihara,et al.  Functional roles of the bone morphogenetic protein system in thyrotropin signaling in porcine thyroid cells. , 2005, Biochemical and biophysical research communications.

[18]  G. Chetrite,et al.  Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer , 2005, The Journal of Steroid Biochemistry and Molecular Biology.

[19]  J. Mester,et al.  Mitogenic activity of estrogens in human breast cancer cells does not rely on direct induction of mitogen-activated protein kinase/extracellularly regulated kinase or phosphatidylinositol 3-kinase. , 2004, Molecular endocrinology.

[20]  D. Bodenner,et al.  Binding of estrogen receptor with estrogen conjugated to bovine serum albumin (BSA) , 2004, Nuclear receptor.

[21]  Charles M Perou,et al.  Statistical modeling for selecting housekeeper genes , 2004, Genome Biology.

[22]  H. Date,et al.  Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action. , 2004, Endocrinology.

[23]  J. Pasqualini The selective estrogen enzyme modulators in breast cancer: a review. , 2004, Biochimica et biophysica acta.

[24]  A. Harris,et al.  Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells. , 2004, International journal of oncology.

[25]  F. Otsuka,et al.  The bone morphogenetic protein system in mammalian reproduction. , 2004, Endocrine reviews.

[26]  F. Otsuka,et al.  Novel action of activin and bone morphogenetic protein in regulating aldosterone production by human adrenocortical cells. , 2004, Endocrinology.

[27]  T. Tamiya,et al.  Involvement of activin/BMP system in development of human pituitary gonadotropinomas and nonfunctioning adenomas. , 2003, Biochemical and biophysical research communications.

[28]  J. Clement,et al.  Differential expression and regulation of bone morphogenetic protein 7 in breast cancer. , 2003, International journal of oncology.

[29]  N. Davidson,et al.  The biology of breast carcinoma , 2003, Cancer.

[30]  A. Blais,et al.  Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer cells. , 2003, Cancer research.

[31]  F. Otsuka,et al.  Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells* , 2003, The Journal of Biological Chemistry.

[32]  F. Otsuka,et al.  A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes. , 2002, Endocrinology.

[33]  S. Bae,et al.  Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein , 2002, Oncogene.

[34]  Tetsuya Yamamoto,et al.  Cross-talk between bone morphogenic proteins and estrogen receptor signaling. , 2002, Endocrinology.

[35]  C. Watson,et al.  The dynamic and elusive membrane estrogen receptor-α , 2002, Steroids.

[36]  M. Valverde,et al.  The estrogen trinity: membrane, cytosolic, and nuclear effects. , 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[37]  G. Chetrite,et al.  Paradoxical effect of estradiol: it can block its own bioformation in human breast cancer cells , 2001, The Journal of Steroid Biochemistry and Molecular Biology.

[38]  K. Miyazono,et al.  Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction. , 2001, Journal of cell science.

[39]  R. Clarke,et al.  Constitutive Expression of the Steroid Sulfatase Gene Supports the Growth of MCF-7 Human Breast Cancer Cells in Vitroand in Vivo. , 2001, Endocrinology.

[40]  J. Thomsen,et al.  Mechanisms of estrogen action. , 2001, Physiological reviews.

[41]  Shin Yamamoto,et al.  Bone Morphogenetic Protein-15 , 2000, The Journal of Biological Chemistry.

[42]  S. F. Arnold,et al.  Identification of bone morphogenetic proteins and their receptors in human breast cancer cell lines: importance of BMP2. , 1999, Cytokine.

[43]  K. Miyazono,et al.  Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. , 1999, Journal of cell science.

[44]  M. Kohno,et al.  Specific Activation of the p38 Mitogen-activated Protein Kinase Signaling Pathway and Induction of Neurite Outgrowth in PC12 Cells by Bone Morphogenetic Protein-2* , 1999, The Journal of Biological Chemistry.

[45]  G. Greene,et al.  Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. , 1999, Molecular endocrinology.

[46]  J. Clement,et al.  Expression of bone morphogenetic protein 6 in normal mammary tissue and breast cancer cell lines and its regulation by epidermal growth factor , 1999, International journal of cancer.

[47]  K. Selcer,et al.  Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines. , 1997, Cancer research.

[48]  C. Falany,et al.  Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines. , 1996, Cancer research.

[49]  K. Helzlsouer,et al.  Hormones and breast cancer , 1995, Cancer.

[50]  S. Noji,et al.  Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors (*) , 1995, The Journal of Biological Chemistry.

[51]  K. Miyazono,et al.  Cloning and characterization of a human type II receptor for bone morphogenetic proteins. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[52]  J. Smith,et al.  Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects , 1995, The Journal of cell biology.

[53]  J. Massagué,et al.  Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs , 1995, Molecular and cellular biology.

[54]  D. Riddle,et al.  Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. , 1994, The Journal of biological chemistry.

[55]  B. Henderson,et al.  Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture. , 1988, Cancer research.

[56]  Takashi Suzuki,et al.  New development in intracrinology of breast carcinoma , 2006, Breast cancer.

[57]  I. Marić,et al.  Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer. , 2005, Croatian medical journal.

[58]  S. Vukicevic,et al.  Bone morphogenetic proteins in development , 2004 .

[59]  F. Pouliot,et al.  Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein-induced growth arrest in human breast cancer cells. , 2002, The Journal of endocrinology.

[60]  R. Santen,et al.  Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation. , 2002, Molecular endocrinology.