A Comparative Study of Trabecular Bone Properties in the Spine and Femur Using High Resolution MRI and CT

The purpose of this study was to use high resolution (HR) magnetic resonance (MR) and computed tomography (CT) images combined with texture analysis to investigate the trabecular structure of human vertebral and femoral specimens and to compare these techniques with bone mineral density (BMD) in the prediction of bone strength. Twenty‐nine bone cubes were harvested from 12 proximal femur cadaver specimens and 29 from 8 spines. HR MR and CT images were obtained, and texture analysis techniques were used to assess trabecular structure. Additionally, BMD, elastic modulus (EM), and maximum compressive strength were determined. R2 for EM versus texture measures computed in the MR images was higher (R2 = 0.27–0.64, p < 0.01) in the spine than in the femur specimens (R2 = 0.12–0.22, p < 0.05). R2 values were similar in the CT images. R2 for EM versus BMD was 0.66 (p < 0.01) in the spine and 0.61 (p < 0.01) in the femur specimens. In the MR images, texture measures combined with BMD in a multivariate‐regression model significantly increased R2, while improvement was less significant in the CT images. Thus, texture analysis may provide additional information needed to analyze bone strength and quality.

[1]  A. B. Hill,et al.  Principles of Medical Statistics , 1950, The Indian Medical Gazette.

[2]  C. A. Davis,et al.  The effects of bone on proton NMR relaxation times of surrounding liquids. , 1986, Investigative radiology.

[3]  M. Drezner,et al.  Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee , 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[4]  A. Parfitt.  Bone histomorphometry: standardization of nomenclature, symbols and units (summary of proposed system). , 1988, Bone.

[5]  H. Lemke.  Computer-assisted radiology. , 1988, Journal of digital imaging.

[6]  P. Brinckmann,et al.  Prediction of the Compressive Strength of Human Lumbar Vertebrae , 1989, Spine.

[7]  Roland T. Chin,et al.  Analysis of Thinning Algorithms Using Mathematical Morphology , 1990, IEEE Trans. Pattern Anal. Mach. Intell..

[8]  C. Netelenbos,et al.  A new method for automatic recognition of the radiographic trabecular pattern , 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[9]  S Majumdar,et al.  Quantitation of the susceptibility difference between trabecular bone and bone marrow: Experimental studies , 1991, Magnetic resonance in medicine.

[10]  F W Wehrli,et al.  In vivo Quantitative characterization of trabecular bone by NMR , 1991, Magnetic resonance in medicine.

[11]  H. Gundersen,et al.  Biologically meaningful determinants of the in vitro strength of lumbar vertebrae. , 1991, Bone.

[12]  W C Hayes,et al.  Biomechanics of fracture risk prediction of the hip and spine by quantitative computed tomography. , 1991, Radiologic clinics of North America.

[13]  T K Foo,et al.  High-resolution MR imaging of the wrist and eye with short TR, short TE, and partial-echo acquisition. , 1992, Radiology.

[14]  P. Rüegsegger,et al.  High-contrast resolution of CT images for bone structure analysis. , 1992, Medical physics.

[15]  S. Majumdar,et al.  In vivo relationship between marrow T2* and trabecular bone density determined with a chemical shift—selective asymmetric spin‐echo sequence , 1992, Journal of magnetic resonance imaging : JMRI.

[16]  R. Huiskes,et al.  Mechanical and textural properties of pelvic trabecular bone. , 1993, Journal of biomechanics.

[17]  T. Ishida,et al.  Trabecular Pattern Analysis Using Fractal Dimension , 1993 .

[18]  M. Hahn,et al.  High Spatial Resolution Imaging of Bone Mineral Using Computed Microtomography: Comparison with Microradiography and Undecalcified Histologic Sections , 1993, Investigative radiology.

[19]  A. Mundinger,et al.  Quantitative image analysis of vertebral body architecture--improved diagnosis in osteoporosis based on high-resolution computed tomography. , 1993, The British journal of radiology.

[20]  S. Majumdar,et al.  Application of fractal geometry techniques to the study of trabecular bone. , 1993, Medical physics.

[21]  F. Wehrli,et al.  High‐resolution variable flip angle 3D MR imaging of trabecular microstructure in vivo , 1993, Magnetic resonance in medicine.

[22]  M. Hahn,et al.  Polyostotic heterogeneity of the spine in osteoporosis. Quantitative analysis and three-dimensional morphology. , 1994, Bone and mineral.

[23]  S A Goldstein,et al.  The relationship between the structural and orthogonal compressive properties of trabecular bone. , 1994, Journal of biomechanics.

[24]  M. Underweiser,et al.  On the fractal nature of trabecular structure. , 1994, Medical physics.

[25]  M. Ito,et al.  Trabecular texture analysis of CT images in the relationship with spinal fracture. , 1995, Radiology.

[26]  Steven D. Kugelmass,et al.  Quantitative analysis of trabecular microstructure by 400 MHz nuclear magnetic resonance imaging , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[27]  W G Geraets,et al.  Longitudinal analysis of radiographic trabecular pattern by image processing. , 1995, Bone.

[28]  S. Majumdar,et al.  Evaluation of technical factors affecting the quantification of trabecular bone structure using magnetic resonance imaging. , 1995, Bone.

[29]  F. Wehrli,et al.  Osteoporosis: clinical assessment with quantitative MR imaging in diagnosis. , 1995, Radiology.

[30]  F. Wehrli,et al.  Three‐dimensional nuclear magnetic resonance microimaging of trabecular bone , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  C. Simmons,et al.  Trabecular bone morphology from micro‐magnetic resonance imaging , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  P. Rüegsegger,et al.  Morphometric analysis of noninvasively assessed bone biopsies: comparison of high-resolution computed tomography and histologic sections. , 1996, Bone.

[33]  M. Hahn,et al.  Heterogeneity of the skeleton: Comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[34]  S. Majumdar,et al.  Correlation of Trabecular Bone Structure with Age, Bone Mineral Density, and Osteoporotic Status: In Vivo Studies in the Distal Radius Using High Resolution Magnetic Resonance Imaging , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[35]  S. Majumdar,et al.  Heterogeneity of Trabecular Bone Structure in the Calcaneus Using Magnetic Resonance Imaging , 1998, Osteoporosis International.