Effects of Oral Caffeine on Postdural Puncture Headache: A Double‐Blind, Placebo‐Controlled Trial

Forty postpartum patients with postdural puncture headache (PDPH) were randomly assigned to receive oral caffeine (300 mg) or a placebo. Intensity of headache, quantitated using a visual analogue pain scale (VAS), was assessed immediately before drug administration and 4 and 24 h later. Relief of PDPH measured as ΔVAS (initial VAS—VAS at 4 h) was significantly better in the caffeine than in the placebo group (P = 0.014). Six patients (30%) whose PDPH was relieved by caffeine at 4 h had recurrence of symptoms the following day. Our study demonstrates that caffeine administered orally provides relief, albeit if sometimes transient, from PDPH with minimal side effects.

[1]  R. Ward,et al.  Disposition of dietary caffeine in milk, saliva, and plasma of lactating women. , 1984, Pediatrics.

[2]  John F. Young,et al.  Caffeine disposition after oral doses , 1982, Clinical pharmacology and therapeutics.

[3]  A H Neims,et al.  The disposition of caffeine during and after pregnancy. , 1981, Seminars in perinatology.

[4]  P. Sechzer.  Post-Spinal Anesthesia Headache Treated with Caffeine. Part II: Intracranial Vascular Distension. A Key Factor , 1981 .

[5]  W. Dodson,et al.  Caffeine secretion into breast milk. , 1979, Archives of disease in childhood.

[6]  M. L. Bunker,et al.  Caffeine content of common beverages. , 1979, Journal of the American Dietetic Association.

[7]  J. Hattingh,et al.  Cerebrovascular effects of cerebrospinal fluid removal. , 1978, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[8]  J. Meyer,et al.  Effect of Cerebrospinal Fluid Removal on Cerebral Blood Flow and Metabolism in the Baboon , 1977, Stroke.

[9]  M Rosen,et al.  The reliability of a linear analogue for evaluating pain , 1976, Anaesthesia.

[10]  P. Novack,et al.  Clinical implications of recent studies on cerebral circulation of man. , 1954, A.M.A. archives of neurology and psychiatry.

[11]  H. Holder.  REACTIONS AFTER SPINAL ANESTHESIA , 1944 .