Zidovudine and HIV: Mathematical models of within‐host population dynamics

[1]  B. Larder,et al.  Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance. , 1994, The Journal of general virology.

[2]  P. Reiss,et al.  RESUMPTION OF HIV ANTIGEN PRODUCTION DURING CONTINUOUS ZIDOVUDINE TREATMENT , 1988, The Lancet.

[3]  D. Ho,et al.  Quantitation of zidovudine-resistant human immunodeficiency virus type 1 in the blood of treated and untreated patients. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[4]  M A Nowak,et al.  Competition between zidovudine‐sensitive and zidovudine‐resistant strains of HIV , 1992, AIDS.

[5]  S D Kemp,et al.  Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). , 1989, Science.

[6]  P D Griffiths,et al.  Population dynamics of HIV within an individual after treatment with zidovudine , 1991, AIDS.

[7]  Martin A. Nowak,et al.  Viral dynamics in human immunodeficiency virus type 1 infection , 1995, Nature.

[8]  A. Perelson,et al.  Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection , 1995, Nature.

[9]  M A Nowak,et al.  Antigenic diversity thresholds and the development of AIDS. , 1991, Science.

[10]  S D Kemp,et al.  Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. , 1991, Science.

[11]  Douglas D. Richman,et al.  The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection a double-blind, placebo-controlled trial , 1990 .

[12]  B. Larder,et al.  Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects. , 1992, The Journal of infectious diseases.

[13]  S. Frost,et al.  Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection , 1994, AIDS.

[14]  J. Coffin,et al.  HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy , 1995, Science.

[15]  F. McCutchan,et al.  Brief report: primary infection with zidovudine-resistant human immunodeficiency virus type 1. , 1993, The New England journal of medicine.

[16]  A. McLean,et al.  The balance of power between HIV and the immune system. , 1993, Trends in microbiology.

[17]  D. Richman,et al.  The antiviral effect of zidovudine and ribavirin in clinical trials and the use of p24 antigen levels as a virologic marker. , 1989, The Journal of infectious diseases.

[18]  B. Larder,et al.  Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy , 1990, The Lancet.

[19]  D. Richman,et al.  HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. , 1989, Science.

[20]  B. Larder,et al.  Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Is antigenic variation of HIV important for AIDS and what might be expected in the future , 1994 .

[22]  D. Richman,et al.  Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates. , 1994, AIDS research and human retroviruses.

[23]  B. Larder,et al.  Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance , 1995, Journal of virology.

[24]  B. Larder,et al.  Effects of discontinuation of zidovudine treatment on zidovudine sensitivity of human immunodeficiency virus type 1 isolates , 1993, Antimicrobial Agents and Chemotherapy.

[25]  A. McLean,et al.  In vivo estimates of division and death rates of human T lymphocytes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[26]  S W Lagakos,et al.  Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection , 1990 .