Urographic changes in diabetes insipidus; report of a case.

The roles of the posterior pituitary gland and the supraopticohypophysial tract in diabetes insipidus 1 have been discussed in all their ramifications in the medical literature. There has, however, been a paucity of reports on the urinary tract changes that occur in this disorder. Osler 2 first described the secondary pathological changes. as follows: "The kidneys have been found enlarged and congested. The bladder has been found hypertrophied. Dilitation of the ureters and pelves of the kidneys has been present." Recently, Weller and co-workers 3 demonstrated these changes urographically. Their case was complicated by secondary hypertension, which was relieved by ureteral meatotomy. The following case is one of idiopathic, hereditary diabetes insipidus uncomplicated by hypertension, in which there were classic urographic changes. REPORT OF A CASE A 25-year-old Japanese man was admitted to Tripler Army Hospital, Honolulu, on Aug. 3, 1951. His symptoms of polydipsia and polyuria with a urine