The robustness of DLP hyperspectral imaging for clinical and surgical utility

Utilizing seed funding from Texas Instruments, a DLP (R)Hyperspectral Imaging system was developed by integrating a focal-plane array, FPA, detector with a DLP based spectrally tunable illumination source. Software is used to synchronize FPA with DLP hardware for collecting spectroscopic images as well as running novel illumination schemes and chemometric deconvolution methods for producing gray scale or color encoded images visualizing molecular constituents at video rate. Optical spectra and spectroscopic image data of a variety of live human organs and diseased tissue collected from patients during surgical procedures and clinical visits being cataloged for a database will be presented.

[1]  M. Gladwin,et al.  Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide. , 2003, American journal of physiology. Heart and circulatory physiology.

[2]  Karel J. Zuzak,et al.  Visible spectroscopic imaging studies of normal and ischemic dermal tissue , 2000, BiOS.

[3]  E. Livingston,et al.  Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery. , 2007, Analytical chemistry.

[4]  Karel J. Zuzak,et al.  Visible and infrared hyperspectral visualization of normal and ischemic tissue , 1999, Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. N.

[5]  Alex Fong.  Advanced photonic tools for hyperspectral imaging in the life sciences , 2008 .

[6]  Jeffrey A. Cadeddu,et al.  DLP hyperspectral imaging for surgical and clinical utility , 2009, MOEMS-MEMS.

[7]  K. Zuzak,et al.  Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion. , 2002, Analytical chemistry.

[8]  M. Gladwin,et al.  Noninvasive Determination of Spatially Resolved and Time-Resolved Tissue Perfusion in Humans During Nitric Oxide Inhibition and Inhalation by Use of a Visible-Reflectance Hyperspectral Imaging Technique , 2001, Circulation.