Effect of interval exercise training programme on C-reactive protein in the non-pharmacological management of hypertension: a randomized controlled trial.

OBJECTIVE Increased serum levels of inflammatory mediators have been associated with numerous disease states including hypertension. C-reactive protein (CRP) levels are associated with future development of hypertension and cardiovascular event in hypertension, which suggests that hypertension, is in part an inflammatory disorder. The objective of this study was to determine the effect of interval training programme on blood pressure and CRP in the non pharmacological management of hypertension. METHODS Two hundred and forty five male subjects with mild to moderate (Systolic Blood Pressure [SBP] between 140-179 & Diastolic Blood Pressure [DBP] between 90-109 mmHg) essential hypertension were age-matched and randomly grouped to interval (n=140) and control groups (n=105). The interval (work: rest ratio of 1:1) groups involved in an 8-weeks interval training programs for between 45-60 minutes, at intensities of 60-79% of HR reserve, while the control group remained sedentary during this period. SBP, DBP, VO2max and CRP were assessed. Students't and Pearson correlation tests were used in data analysis. RESULTS Findings of the study revealed significant effect of interval exercise training program on SBP, DBP and CRP. The study also showed positive significant correlation between changes in CRP and changes in SBP (r=225) and DBP (r= .324) at p<0.05. CONCLUSIONS It was concluded that moderate intensity interval training programs is effective in the non-pharmacological management of hypertension and may prevent cardiovascular event through the down regulation of CRP in hypertension.

[1]  S. Lamina,et al.  Therapeutic Effect of an Interval Exercise Training Program in the Management of Erectile Dysfunction in Hypertensive Patients , 2009, Journal of clinical hypertension.

[2]  Peter Schlattmann,et al.  Too Old to Benefit from Sports? The Cardiovascular Effects of Exercise Training in Elderly Subjects Treated for Isolated Systolic Hypertension , 2007, Kidney and Blood Pressure Research.

[3]  M. Rondon,et al.  Exercise Training Restores Baroreflex Sensitivity in Never-Treated Hypertensive Patients , 2007, Hypertension.

[4]  G. Watts,et al.  The erectile–endothelial dysfunction nexus: new opportunities for cardiovascular risk prevention , 2007, Nature Clinical Practice Cardiovascular Medicine.

[5]  I. Kullo,et al.  Markers of inflammation are inversely associated with VO2 max in asymptomatic men. , 2007, Journal of applied physiology.

[6]  J. Sinacore,et al.  Impact of exercise (walking) on blood pressure levels in African American adults with newly diagnosed hypertension. , 2007, Ethnicity & disease.

[7]  S. Anderssen,et al.  Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension. , 2006, American journal of hypertension.

[8]  Y. On,et al.  Are low total serum antioxidant status and elevated levels of C-reactive protein and monocyte chemotactic protein-1 associated with cardiac syndrome X? , 2005, Circulation journal : official journal of the Japanese Circulation Society.

[9]  Jing Ma,et al.  Inflammatory markers and the risk of coronary heart disease in men and women. , 2004, The New England journal of medicine.

[10]  G. Zaloga,et al.  C-reactive protein: from innocent bystander to pivotal mediator of atherosclerosis. , 2004, The American journal of medicine.

[11]  P. Ridker.  High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit. , 2004, American heart journal.

[12]  R. Klein,et al.  Relationship between white blood cell count and incident hypertension , 2004 .

[13]  P. Ridker,et al.  C-reactive protein and the risk of developing hypertension. , 2003, JAMA.

[14]  L. Ferrucci,et al.  Is chronic inflammation a determinant of blood pressure in the elderly? , 2003, American journal of hypertension.

[15]  P. Freedson,et al.  Body mass index, but not physical activity, is associated with C-reactive protein. , 2003, Medicine and science in sports and exercise.

[16]  A. Vinik,et al.  Etiology and treatment of erectile failure in diabetes mellitus , 2002, Current diabetes reports.

[17]  J. Kampert,et al.  Associations Between Cardiorespiratory Fitness and C-Reactive Protein in Men , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[18]  Sridevi Devaraj,et al.  Demonstration That C-Reactive Protein Decreases eNOS Expression and Bioactivity in Human Aortic Endothelial Cells , 2002, Circulation.

[19]  James T. Willerson,et al.  Modulation of C-Reactive Protein–Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs , 2001 .

[20]  J. Callés-Escandon,et al.  Diabetes and endothelial dysfunction: a clinical perspective. , 2001, Endocrine reviews.

[21]  L. Ferrucci,et al.  Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[22]  T. Kanda,et al.  Moderate-intensity regular exercise decreases serum tumor necrosis factor-α and HbA1c levels in healthy women , 2000, International Journal of Obesity.

[23]  T. Strandberg,et al.  C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[24]  Physical Activity, Physical Fitness, and Hypertension , 1998 .

[25]  L. Kuller,et al.  Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[26]  A. Swank.  Exercise Physiology: Human Bioenergetics and its Application, 2nd Edition , 1996 .

[27]  A. J. Walker,et al.  Cardiovascular and plasma catecholamine responses to exercise in blacks and whites. , 1992, Hypertension.

[28]  A. O. Akinpelu.  Responses of the African hypertensive to exercise training: preliminary observations. , 1990, Journal of human hypertension.

[29]  P. Korner,et al.  EFFECT OF CHANGING LEVELS OF PHYSICAL ACTIVITY ON BLOOD-PRESSURE AND HAEMODYNAMICS IN ESSENTIAL HYPERTENSION , 1986, The Lancet.

[30]  G. Gau.  Exercise in Health and Disease: Evaluation and Prescription for Prevention and Rehabilitation , 1985 .

[31]  Allan H. Goldfarb,et al.  Exercise Physiology: Human Bioenergetics and its Application , 1985 .

[32]  H. Pitkow,et al.  Basic and Clinical Pharmacology , 1983 .