Detection of two variants of complement component C3 in C3-deficient guinea pigs distinguished by the absence and presence of a thiolester.

[1]  H. Colten,et al.  Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA. , 1999, Immunopharmacology.

[2]  John D Lambris,et al.  Complement diversity: a mechanism for generating immune diversity? , 1998, Immunology today.

[3]  M. Gadjeva,et al.  The covalent binding reaction of complement component C3. , 1998, Journal of immunology.

[4]  J. Alexander,et al.  Immune complex glomerulonephritis in C4- and C3-deficient mice. , 1998, Kidney international.

[5]  J. Murrow,et al.  Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement. , 1997, Journal of immunology.

[6]  S. Law,et al.  The internal thioester and the covalent binding properties of the complement proteins C3 and C4 , 1997, Protein science : a publication of the Protein Society.

[7]  M. Lokki,et al.  Inherited complement C3 deficiency: reduced C3 mRNA and protein levels in a Laotian kindred. , 1996, Clinical immunology and immunopathology.

[8]  E. Kremmer,et al.  Regulation of the B cell response to T-dependent antigens by classical pathway complement. , 1996, Journal of immunology.

[9]  A. Willis,et al.  The reaction mechanism of the internal thioester in the human complement component C4 , 1996, Nature.

[10]  P. Butko,et al.  Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[11]  C. Natanson,et al.  The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure , 1994, The Journal of experimental medicine.

[12]  M. Pangburn,et al.  Spontaneous thioester bond formation in α2‐macroglobulin, C3 and C4 , 1992 .

[13]  M. Pangburn Spontaneous reformation of the intramolecular thioester in complement protein C3 and low temperature capture of a conformational intermediate capable of reformation. , 1992, The Journal of biological chemistry.

[14]  C. Hammer,et al.  A rapid FPLC method for purification of the third component of human and guinea pig complement. , 1991, Journal of immunological methods.

[15]  H. Colten,et al.  Molecular basis of complement C3 deficiency in guinea pigs. , 1990, The Journal of clinical investigation.

[16]  J. Tranum-Jensen,et al.  Hereditary, Complete Deficiency of Complement Factor H Associated with Recurrent Meningococcal Disease , 1989, Scandinavian journal of immunology.

[17]  P. Sánchez-Corral,et al.  Separation of active and inactive forms of the third component of human complement, C3, by fast protein liquid chromatography (FPLC). , 1989, Journal of immunological methods.

[18]  R. Burger,et al.  Functional analysis and quantification of the complement C3 derived anaphylatoxin C3a with a monoclonal antibody. , 1987, Clinical and experimental immunology.

[19]  I. Brandslund,et al.  A Family with Complement Factor I Deficiency , 1986, Scandinavian journal of immunology.

[20]  T. Tobe,et al.  Biosynthesis of the internal thioester bond of the third component of complement. , 1984, Journal of biochemistry.

[21]  D. Isenman Conformational changes accompanying proteolytic cleavage of human complement protein C3b by the regulatory enzyme factor I and its cofactor H. Spectroscopic and enzymological studies. , 1983, The Journal of biological chemistry.

[22]  D. Bitter‐Suermann,et al.  Identification of functionally relevant determinants on the complement component C3 with monoclonal antibodies. , 1982, Journal of immunology.

[23]  F. Rosen,et al.  Binding of C3b proceeds by a transesterification reaction at the thiolester site , 1982, Nature.

[24]  M. Pangburn,et al.  Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties. , 1981, Biochemistry.

[25]  D. Bitter‐Suermann,et al.  Platelet-serotonin release by C3a and C5a: two independent pathways of activation. , 1981, Journal of immunology.

[26]  R. Levine,et al.  Covalent binding and hemolytic activity of complement proteins. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[27]  M. Thomas,et al.  Evidence for presence of an internal thiolester bond in third component of human complement. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R. Levine,et al.  Interaction between the third complement protein and cell surface macromolecules. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[29]  D. Bitter‐Suermann,et al.  Independent and consecutive action of C5, C6 and C7 in immune hemolysis. II. Formation and decay of the intermediate complexes EAC1-5 and EAC1-6. , 1970, Immunochemistry.

[30]  D. Bitter‐Suermann,et al.  Independent and consecutive action of the complement components C5, C6 and C7 in immune hemolysis. I. Preparation of EAC1-5 with purified guinea pig C3 and C5. , 1970, Immunochemistry.

[31]  F. Rosen,et al.  Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection. , 1970, The Journal of clinical investigation.

[32]  M. Carroll,et al.  The role of complement and complement receptors in induction and regulation of immunity. , 1998, Annual review of immunology.

[33]  D. Fearon,et al.  The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. , 1995, Annual review of immunology.

[34]  H. Colten,et al.  Complement C3 deficiency: human, animal, and experimental models. , 1994, Pathobiology : journal of immunopathology, molecular and cellular biology.

[35]  R. V. van Lier,et al.  Dual antigen recognition by B cells. , 1993, Immunology today.

[36]  D. Bitter‐Suermann,et al.  Impaired humoral immune response in complement C3‐deficient guinea pigs: absence of secondary antibody response , 1986, European journal of immunology.

[37]  J. Gordon,et al.  An inherited deficiency of the third component of complement, C3, in guinea pigs , 1986, European journal of immunology.

[38]  Robert B Sim,et al.  Autolytic fragmentation of complement components C3 and C4 under denaturing conditions, a property shared with alpha 2-macroglobulin. , 1981, The Biochemical journal.

[39]  Robert B Sim,et al.  The covalent-binding reaction of complement component C3. , 1981, The Biochemical journal.

[40]  H. Colten Biosynthesis of complement. , 1976, Advances in immunology.