Detection of Odorous Substances by Using a Lipid-Coated Quartz-Crystal Microbalance in the Gas Phase

The adsorption behaviors and partition coefficients of various odorants and perfumes in a lipid matrix were measured in the gas phase using a dimethyldioctadecylammonium poly(styrene-4-sulfonate) multibilayer film-coated quartz-crystal microbalance (QCM), the resonance frequency of which changes linearly with increasing the absorption amount on the lipid matrix on the QCM. A good correlation was observed between the partition coefficients of various odorous substances or perfumes in the lipid matrix and the odor intensity in humans obtained by smelling tests for the same compounds. A similar relation was observed regarding the absorption behavior to an olfactory epithelium-coated QCM in the gas phase. Odorant having a strong intensity showed higher adsorption in the lipid matrix on the QCM. The partition coefficients increased in the solid state of the lipid matrix, compared with the fluid-liquid crystalline state. As compared with absorption experiments in the aqueous phase, the high partition coefficien...

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