Measuring regional myocardial blood flow with 133Xe and the Anger camera.

Regional myocardial blood flow was measured using the inert gas washout technique and the Anger scintillation camera following injection of 133Xe into the coronary artery. By applying compartmental analysis to 30-minute washout curves, three compartments were delineated, representing blood flow to fat (IIIF) and myocardium (IM and IIM). Regional heterogeneity of flow was a highly sensitive index of coronary artery disease. Functional images delineated areas of altered perfusion better than quadrantic flow values. Gamma camera images of initial xenon distribution identified patients with severely altered flow.

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