Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins.

[1]  K. Malcolm,et al.  Evidence for Rho-mediated Agonist Stimulation of Phospholipase D in Rat1 Fibroblasts , 1996, The Journal of Biological Chemistry.

[2]  D. Cussac,et al.  Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation (*) , 1996, The Journal of Biological Chemistry.

[3]  E. Chaves-Olarte,et al.  UDP-Glucose Deficiency in a Mutant Cell Line Protects against Glucosyltransferase Toxins from Clostridium difficile and Clostridium sordellii(*) , 1996, The Journal of Biological Chemistry.

[4]  U. Francke,et al.  Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization , 1996, Cell.

[5]  K. Jakobs,et al.  Inhibition of Receptor Signaling to Phospholipase D by Clostridium difficile Toxin B , 1996, The Journal of Biological Chemistry.

[6]  K. Fujisawa,et al.  Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho , 1996, Science.

[7]  P. Boquet,et al.  Transient expression of RhoA, -B, and -C GTPases in HeLa cells potentiates resistance to Clostridium difficile toxins A and B but not to Clostridium sordellii lethal toxin , 1995, Infection and immunity.

[8]  A. Rapak,et al.  Farnesylation of CaaX-tagged diphtheria toxin A-fragment as a measure of transfer to the cytosol. , 1995, Biochemistry.

[9]  M. Mann,et al.  Glucosylation of Rho proteins by Clostridium difficile toxin B , 1995, Nature.

[10]  M. Gibert,et al.  Botulinal neurotoxin C1 complex genes, clostridial neurotoxin homology and genetic transfer in Clostridium botulinum. , 1995, Toxicon : official journal of the International Society on Toxinology.

[11]  Alfred Wittinghofer,et al.  Quantitative Analysis of the Complex between p21 and the Ras-binding Domain of the Human Raf-1 Protein Kinase (*) , 1995, The Journal of Biological Chemistry.

[12]  L. Chong,et al.  The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells , 1994, Cell.

[13]  G. Blobel,et al.  A G protein involved in nucleocytoplasmic transport: the role of Ran. , 1994, Trends in biochemical sciences.

[14]  T. Wilkins,et al.  Mutagenesis of the Clostridium difficile toxin B gene and effect on cytotoxic activity. , 1994, Microbial pathogenesis.

[15]  Mark S. Boguski,et al.  Proteins regulating Ras and its relatives , 1993, Nature.

[16]  M. Marshall,et al.  The effector interactions of p21ras. , 1993, Trends in biochemical sciences.

[17]  F. Benfenati,et al.  Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin , 1992, Nature.

[18]  H. Kuramitsu,et al.  Evidence for a modular structure of the homologous repetitive C-terminal carbohydrate-binding sites of Clostridium difficile toxins and Streptococcus mutans glucosyltransferases , 1992, Journal of bacteriology.

[19]  C. von Eichel-Streiber,et al.  Morphological changes of cultured endothelial cells after microinjection of toxins that act on the cytoskeleton , 1992, Infection and immunity.

[20]  T. Wilkins,et al.  Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin A , 1992, Infection and immunity.

[21]  U. Hadding,et al.  Monoclonal antibodies specific for Clostridium difficile toxin B and their use in immunoassays , 1992, Journal of clinical microbiology.

[22]  Katherine A. Kantardjieff,et al.  The crystal structure of diphtheria toxin , 1992, Nature.

[23]  C. von Eichel-Streiber,et al.  Morphological changes in adherent cells induced by Clostridium difficile toxins. , 1991, Biochemical Society transactions.

[24]  I. Florin.  Isolation of a fibroblast mutant resistant to Clostridium difficile toxins A and B. , 1991, Microbial pathogenesis.

[25]  T. Sixma,et al.  Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli , 1991, Nature.

[26]  Frank McCormick,et al.  The GTPase superfamily: conserved structure and molecular mechanism , 1991, Nature.

[27]  T. Wilkins,et al.  Toxin A of Clostridium difficile is a potent cytotoxin , 1990, Journal of clinical microbiology.

[28]  Y. Takeda,et al.  Demonstration of RNA N‐Glycosidase Activity of a Vero Toxin (VT2 Variant) Produced by Escherichia coli 091: H21 from a Patient with the Hemolytic Uremic Syndrome , 1990, Microbiology and immunology.

[29]  J. Johnson,et al.  Molecular characterization of the Clostridium difficile toxin A gene , 1990, Infection and immunity.

[30]  S. Narumiya,et al.  Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. , 1989, The Journal of biological chemistry.

[31]  T. Wilkins,et al.  Purification and characterization of Clostridium sordellii hemorrhagic toxin and cross-reactivity with Clostridium difficile toxin A (enterotoxin) , 1988, Infection and immunity.

[32]  M. Popoff.  Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile cytotoxin , 1987, Infection and immunity.

[33]  M. Rechsteiner,et al.  Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles , 1982, Cell.

[34]  P. Boquet,et al.  Inhibition of p21 Rho in intact cells by C3 diphtheria toxin chimera proteins. , 1995, Methods in enzymology.

[35]  H. Monteil,et al.  Cloning and characterization of the cytotoxin L-encoding gene of Clostridium sordellii: homology with Clostridium difficile cytotoxin B. , 1995, Gene.

[36]  Joel Moss,et al.  Bacterial toxins and virulence factors in disease , 1995 .

[37]  A. Hall,et al.  Small GTP-binding proteins and the regulation of the actin cytoskeleton. , 1994, Annual review of cell biology.

[38]  C. von Eichel-Streiber,et al.  A comparative biochemical, pharmacological and immunological study of Clostridium novyi alpha-toxin, C. difficile toxin B and C. sordellii lethal toxin. , 1991, Toxicon : official journal of the International Society on Toxinology.