Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes

Growth factor stimulation moves O-glycosylation initiation enzymes (GalNac-Ts) from the Golgi to the ER in a Src-dependent fashion, increasing protein O-glycosylation.

[1]  C. Bertozzi,et al.  In Vivo Imaging of Caenorhabditis elegans Glycans , 2009, ACS chemical biology.

[2]  I. Brockhausen,et al.  Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2. , 2009, Biochimica et biophysica acta.

[3]  D. Bar-Sagi,et al.  Ras/MAPK signaling from endomembranes , 2009, Molecular oncology.

[4]  T. A. Fritz,et al.  Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. , 2009, Endocrinology.

[5]  E. Tian,et al.  Recent insights into the biological roles of mucin-type O-glycosylation , 2009, Glycoconjugate Journal.

[6]  V. Hsu,et al.  The evolving understanding of COPI vesicle formation , 2009, Nature Reviews Molecular Cell Biology.

[7]  G. Omenn,et al.  Mucin glycosylation is altered by pro-inflammatory signaling in pancreatic-cancer cells. , 2008, Journal of proteome research.

[8]  Liping Zhang,et al.  A Mucin-type O-Glycosyltransferase Modulates Cell Adhesion during Drosophila Development*S⃞ , 2008, Journal of Biological Chemistry.

[9]  P. Crocker,et al.  Siglecs as positive and negative regulators of the immune system. , 2008, Biochemical Society transactions.

[10]  Yi Xiang,et al.  ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65 , 2008, The Journal of cell biology.

[11]  A. Luini,et al.  A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway , 2008, Nature Cell Biology.

[12]  C. Bertozzi,et al.  In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish , 2008, Science.

[13]  Henrik Clausen,et al.  Mucin-type O-glycosylation and its potential use in drug and vaccine development. , 2008, Biochimica et biophysica acta.

[14]  V. Malhotra,et al.  Dimeric PKD regulates membrane fission to form transport carriers at the TGN , 2007, The Journal of cell biology.

[15]  Klaus Ley,et al.  Initiation of Protein O Glycosylation by the Polypeptide GalNAcT-1 in Vascular Biology and Humoral Immunity , 2007, Molecular and Cellular Biology.

[16]  D. Corda,et al.  Mitosis controls the Golgi and the Golgi controls mitosis. , 2007, Current opinion in cell biology.

[17]  T. Irimura,et al.  The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation. , 2007, Glycobiology.

[18]  V. Malhotra,et al.  The formation of TGN-to-plasma-membrane transport carriers. , 2006, Annual review of cell and developmental biology.

[19]  Anne Imberty,et al.  Biochemical and Structural Analysis of Helix pomatia Agglutinin , 2006, Journal of Biological Chemistry.

[20]  T. Strom,et al.  Polypeptide GalNAc-transferase T3 and Familial Tumoral Calcinosis , 2006, Journal of Biological Chemistry.

[21]  Hudson H. Freeze,et al.  Genetic defects in the human glycome , 2006, Nature Reviews Genetics.

[22]  I. Brockhausen,et al.  Mucin‐type O‐glycans in human colon and breast cancer: glycodynamics and functions , 2006, EMBO reports.

[23]  Crislyn D'Souza-Schorey,et al.  ARF proteins: roles in membrane traffic and beyond , 2006, Nature Reviews Molecular Cell Biology.

[24]  M. Philips,et al.  Ras signaling on the Golgi. , 2006, Current opinion in cell biology.

[25]  Carolyn R Bertozzi,et al.  The chemistry and biology of mucin-type O-linked glycosylation. , 2005, Bioorganic & medicinal chemistry.

[26]  J. Lippincott-Schwartz,et al.  Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway , 2005, The Journal of cell biology.

[27]  V. Malhotra,et al.  PKCη is required for β1γ2/β3γ2- and PKD-mediated transport to the cell surface and the organization of the Golgi apparatus , 2005, The Journal of cell biology.

[28]  G. Courtand,et al.  Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration , 2005, Breast Cancer Research and Treatment.

[29]  L. Pelletier,et al.  Golgin Tethers Define Subpopulations of COPI Vesicles , 2005, Science.

[30]  R. Roskoski,et al.  Src protein-tyrosine kinase structure and regulation. , 2004, Biochemical and biophysical research communications.

[31]  Joseph Shiloach,et al.  The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  J. Le Pendu,et al.  Expression of sialyl-Tn epitopes on β1 integrin alters epithelial cell phenotype, proliferation and haptotaxis , 2004, Journal of Cell Science.

[33]  T. Gerken,et al.  Role of peptide sequence and neighboring residue glycosylation on the substrate specificity of the uridine 5'-diphosphate-alpha-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyl transferases T1 and T2: kinetic modeling of the porcine and canine submaxillary gland mucin tandem repeats. , 2004, Biochemistry.

[34]  Timothy J. Yeatman,et al.  A renaissance for SRC , 2004, Nature Reviews Cancer.

[35]  K. Ley,et al.  Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation , 2004, Nature Reviews Immunology.

[36]  Robert Kopajtich,et al.  YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3ζ , 2004, The Journal of cell biology.

[37]  V. Malhotra,et al.  Src Regulates Golgi Structure and KDEL Receptor-dependent Retrograde Transport to the Endoplasmic Reticulum* , 2003, Journal of Biological Chemistry.

[38]  T. Gerken,et al.  Mucin Core O-Glycosylation Is Modulated by Neighboring Residue Glycosylation Status , 2002, The Journal of Biological Chemistry.

[39]  S. Müller,et al.  Recombinant MUC1 Probe Authentically Reflects Cell-specific O-Glycosylation Profiles of Endogenous Breast Cancer Mucin , 2002, The Journal of Biological Chemistry.

[40]  Peter Roepstorff,et al.  Functional Conservation of Subfamilies of Putative UDP-N-acetylgalactosamine:Polypeptide N-Acetylgalactosaminyltransferases inDrosophila, Caenorhabditis elegans, and Mammals , 2002, The Journal of Biological Chemistry.

[41]  J. B. Sajous,et al.  Ras signalling on the endoplasmic reticulum and the Golgi , 2002, Nature Cell Biology.

[42]  V. Malhotra,et al.  Protein kinase D: an intracellular traffic regulator on the move. , 2002, Trends in cell biology.

[43]  R. Spiro.  Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds. , 2002, Glycobiology.

[44]  M. Weiss,et al.  Sorting of Golgi resident proteins into different subpopulations of COPI vesicles , 2001, The Journal of cell biology.

[45]  F. Hanisch,et al.  O-Glycosylation of the Mucin Type , 2001, Biological chemistry.

[46]  V. Malhotra,et al.  Protein Kinase D Regulates the Fission of Cell Surface Destined Transport Carriers from the Trans-Golgi Network , 2001, Cell.

[47]  S. Müller,et al.  MUC1: the polymorphic appearance of a human mucin. , 2000, Glycobiology.

[48]  S. Tsuboi,et al.  Mucin-type O-glycans and leukosialin. , 1999, Biochimica et biophysica acta.

[49]  V. Malhotra,et al.  Gβγ-Mediated Regulation of Golgi Organization Is through the Direct Activation of Protein Kinase D , 1999, Cell.

[50]  J. Peter-Katalinic,et al.  High Density O-Glycosylation on Tandem Repeat Peptide from Secretory MUC1 of T47D Breast Cancer Cells* , 1999, The Journal of Biological Chemistry.

[51]  Jonathan A. Cooper,et al.  Src family kinases are required for integrin but not PDGFR signal transduction , 1999, The EMBO journal.

[52]  Andrew Gooley,et al.  Localization of O-Glycosylation Sites on Glycopeptide Fragments from Lactation-associated MUC1 , 1997, The Journal of Biological Chemistry.

[53]  R. Hill,et al.  Subcellular localization of the UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-mediated O-glycosylation reaction in the submaxillary gland. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[54]  W. Balch,et al.  Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus. , 1994, The Journal of biological chemistry.

[55]  T. Irimura,et al.  Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. , 1993, Cancer research.

[56]  G. Staal,et al.  Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product. , 1992, Cancer research.

[57]  J. Perez-Vilar,et al.  Presence of terminal N-acetylgalactosamine residues in subregions of the endoplasmic reticulum is influenced by cell differentiation in culture. , 1991, The Journal of biological chemistry.

[58]  Y. Nouvian‐Dooghe,et al.  Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells , 1990, The Journal of cell biology.

[59]  S. Hakomori,et al.  Sialosyl‐Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients , 1990, Cancer.

[60]  R. Cummings,et al.  Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex , 1988, The Journal of cell biology.

[61]  J. Tooze,et al.  Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of mouse hepatitis virus-A59 , 1988, The Journal of cell biology.

[62]  C. Bertozzi,et al.  Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation , 2007, Nature Protocols.

[63]  A. Furlan,et al.  ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity. , 2006, Glycobiology.

[64]  C. Preisinger,et al.  Kinases regulating Golgi apparatus structure and function. , 2005, Biochemical Society symposium.

[65]  M. Reddish,et al.  Different modes of sialyl-Tn expression during malignant transformation of human colonic mucosa , 2004, Glycoconjugate Journal.

[66]  Lawrence A Tabak,et al.  All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases. , 2003, Glycobiology.

[67]  R. Baron,et al.  Molecular complexes that contain both c-Cbl and c-Src associate with Golgi membranes. , 2002, European journal of cell biology.

[68]  M. Hollingsworth,et al.  Functional Conservation of Subfamilies of Putative UDP-N-acetylgalactosamine:Polypeptide N-Acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and Mammals ONE SUBFAMILY COMPOSED OF l(2)35Aa IS ESSENTIAL IN DROSOPHILA* , 2002 .

[69]  V. Malhotra,et al.  Gbetagamma-mediated regulation of Golgi organization is through the direct activation of protein kinase D. , 1999, Cell.

[70]  E. Berger,et al.  Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. , 1998, Journal of cell science.

[71]  Sheila M. Thomas,et al.  Cellular functions regulated by Src family kinases. , 1997, Annual review of cell and developmental biology.