Noninvasive blood flow imaging for real‐time feedback during laser therapy of port wine stain birthmarks

During laser therapy of port wine stain (PWS) birthmarks, regions of persistent perfusion may exist. Immediate retreatment of such regions may improve PWS laser therapeutic outcome. To address this need, we propose use of laser speckle imaging (LSI) to provide real‐time, quantitative feedback during laser surgery. Herein, we present in vitro and in vivo data collected with a clinic‐based LSI instrument.

[1]  Bernard Choi,et al.  The importance of long-term monitoring to evaluate the microvascular response to light-based therapies. , 2008, The Journal of investigative dermatology.

[2]  B. Weber,et al.  Quantitative modeling of laser speckle imaging. , 2006, Optics letters.

[3]  D. McGill,et al.  The effect of ambient temperature on capillary vascular malformations , 2006, The British journal of dermatology.

[4]  J. Nelson,et al.  Description and analysis of treatments for port-wine stain birthmarks. , 2005, Archives of facial plastic surgery.

[5]  D. Durian,et al.  Speckle-visibility spectroscopy: A tool to study time-varying dynamics , 2005, cond-mat/0506081.

[6]  Bernard Choi,et al.  Determination of optimal view angles for quantitative facial image analysis. , 2005, Journal of Biomedical Optics.

[7]  Kevin R. Forrester,et al.  A laser speckle imaging technique for measuring tissue perfusion , 2004, IEEE Transactions on Biomedical Engineering.

[8]  Bernard Choi,et al.  Laser speckle imaging for monitoring blood flow dynamics in the in vivo rodent dorsal skin fold model. , 2004, Microvascular research.

[9]  Q. Luo,et al.  Modified laser speckle imaging method with improved spatial resolution. , 2003, Journal of biomedical optics.

[10]  Zhihua Ding,et al.  Phase-resolved functional optical coherence tomography: simultaneous imaging of in situ tissue structure, blood flow velocity, standard deviation, birefringence, and Stokes vectors in human skin. , 2002, Optics letters.

[11]  J. Nelson,et al.  Imaging blood flow in human port-wine stain in situ and in real time using optical Doppler tomography. , 2001, Archives of dermatology.

[12]  Zhongping Chen,et al.  Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity. , 2000, Optics letters.

[13]  A. Troilius,et al.  Patients with Port‐Wine Stains and Their Psychosocial Reactions After Photothermolytic Treatment , 2000, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[14]  Lanigan.  Port‐wine stains unresponsive to pulsed dye laser: explanations and solutions , 1998, The British journal of dermatology.

[15]  P. Bossuyt,et al.  Effect of the timing of treatment of port-wine stains with the flash-lamp-pumped pulsed-dye laser. , 1998, The New England journal of medicine.

[16]  L Wang,et al.  MCML--Monte Carlo modeling of light transport in multi-layered tissues. , 1995, Computer methods and programs in biomedicine.

[17]  M. Malm,et al.  Calcitonin Gene–Related Peptide Increases the Blood Flow of Port‐Wine Stains and Improves Continuous‐Wave Dye Laser Treatment , 1993, Plastic and reconstructive surgery.

[18]  G. Nilsson,et al.  Evaluation of port wine stain perfusion by laser Doppler imaging and thermography before and after argon laser treatment. , 1992, Acta dermato-venereologica.

[19]  W. Weston,et al.  Location of port-wine stains and the likelihood of ophthalmic and/or central nervous system complications. , 1991, Pediatrics.

[20]  R G Geronemus,et al.  Capillary hemangiomas and treatment with the flash lamp-pumped pulsed dye laser. , 1991, Archives of dermatology.

[21]  J. Walkup,et al.  Statistical optics , 1986, IEEE Journal of Quantum Electronics.

[22]  J. Briers,et al.  Flow visualization by means of single-exposure speckle photography , 1981 .