SURVIVAL OF RADIOCHROMIUM-LABELED PLATELETS IN THROMBOCYTOPENIAS.

Platelet survival studies were performed by the radiochromium method in 280 patients. Although various types of patients were studied, markedly accelerated platelet destruction was encountered only in those with ITP. No thrombocytopenic patient was found with accelerated platelet production and changes in platelet count with therapy reflected corresponding changes in survival. The use of surface scanning showed that patients with significant splenic localization were more suitable candidates for splenectomy that those without this localization.

[1]  T. Elgvin Platelet antibodies in Hodgkin's disease. , 2009, Acta medica Scandinavica.

[2]  J. Dausset,et al.  Study of leukopenias and thrombocytopenias by the direct antiglobulin consumption test on leukocytes and/or platelets. , 1961, Blood.

[3]  J. Loghem,et al.  Studies on Platelet Antibodies in Man , 1961 .

[4]  G. Barnett,et al.  Reclassification of the thrombocytopenias by the Cr51-labeling method for measuring platelet life span. , 1961, The New England journal of medicine.

[5]  J. Tullis The role of leukocyte and platelet antibody tests in management of diverse clinical disorders. , 1961, Annals of internal medicine.

[6]  B. Bouroncle,et al.  IDIOPATHIC AND SECONDARY THROMBOCYTOPENIC PURPURA: CLINICAL STUDY AND EVALUATION OF 381 CASES OVER A PERIOD OF 28 YEARS , 1960 .

[7]  W. Dameshek CONTROVERSY IN IDIOPATHIC THROMBOCYTOPENIC PURPURA , 1960 .

[8]  J. Lewis,et al.  Immunocytochemical studies on platelets. The demonstration of a common antigen in human platelets and megakaryocytes. , 1960, Blood.

[9]  E. Adelson,et al.  Platelet and fibrinogen sequestration. , 1960, Blood.

[10]  F. Gardner,et al.  Survival of blood platelets labeled with chromium. , 1958, The Journal of clinical investigation.

[11]  N. G. Nordenson Clinical aspects of chronic idiopathic thrombocytopenia. , 1957, Acta haematologica.

[12]  J. J. Mcgovern Platelet transfusions in pediatrics. , 1957, The New England journal of medicine.

[13]  J. Mold,et al.  Study of Transfused Platelets in a Case of Congenital Hypoplastic Thrombocytopenia , 1956, British medical journal.

[14]  M. Paulssen,et al.  Transfusions of Suspensions of Blood Platelets in Thrombocytopenia and Thrombopathia , 1953, Journal of clinical pathology.

[15]  W. Harrington,et al.  Platelet transfusions and the pathogenesis of idiopathic thrombocytopenic purpura. , 1952, Journal of the American Medical Association.

[16]  T. McDonald,et al.  Response of rat megakaryocytes and platelets to bleeding. , 1962, Acta haematologica.

[17]  C. Finch,et al.  A Study of Thrombopoiesis in Induced Acute Thrombocytopenia , 1960 .