Microbial transformation of isocoronarin D by Cunninghamella echinulata NRRL 1386

Abstract The diterpene isocoronarin D (1) is a bioactive major constituent of labdane diterpene from the aerial parts of Curcuma comosa Roxb. (Zingiberaceae), the Thai medicinal plant. Microbial transformation of 1 was performed by the fungus Cunninghamella echinulata NRRL 1386 to yield three new metabolites, 3β-hydroxyisocoronarin D (2), 6α-hydroxyisocoronarin D (3) and 3β,7α-dihydroxyisocoronarin D (4). The structures of the new compounds were elucidated by spectroscopic techniques.

[1]  肖秀玲.  Cunninghamella echinulata , 2012, CABI Compendium.

[2]  M. Choudhary,et al.  Microbial transformation of contraceptive drug etonogestrel into new metabolites with Cunninghamella blakesleeana and Cunninghamella echinulata , 2016, Steroids.

[3]  Ziren Su,et al.  Biotransformation of patchoulol by Cunninghamella echinulata var. elegans. , 2016, Fitoterapia.

[4]  Lixia Chen,et al.  Stereo- and regiospecific biotransformation of curcumenol by four fungal strains , 2015 .

[5]  Usama A. Mahalel,et al.  Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review , 2014, Journal of advanced research.

[6]  M. Choudhary,et al.  Microbial transformation of nandrolone with Cunninghamella echinulata and Cunninghamella blakesleeana and evaluation of leishmaniacidal activity of transformed products , 2014, Steroids.

[7]  C. Murphy.  Drug metabolism in microorganisms , 2014, Biotechnology Letters.

[8]  A. Suksamrarn,et al.  Potent vasorelaxant analogs from chemical modification and biotransformation of isosteviol. , 2013, European journal of medicinal chemistry.

[9]  Jin-Ming Gao,et al.  Microbiological transformation of diosgenin by resting cells of filamentous fungus, Cunninghamella echinulata CGMCC 3.2716 , 2010 .

[10]  T. Kuzuyama,et al.  Microbial glucosylation of flavonols by Cunninghamella echinulata. , 2010, Journal of bioscience and bioengineering.

[11]  E. Bedir,et al.  Biotransformation of cycloastragenol by Cunninghamella blakesleeana NRRL 1369 resulting in a novel framework. , 2010, Organic letters.

[12]  C. Murphy,et al.  Biotransformation of Flurbiprofen by Cunninghamella Species , 2010, Applied and Environmental Microbiology.

[13]  A. Suksamrarn,et al.  Protection of centrilobular necrosis by Curcuma comosa Roxb. in carbon tetrachloride-induced mice liver injury. , 2010, Journal of ethnopharmacology.

[14]  J. Vadolas,et al.  Labdane diterpenes from the aerial parts of Curcuma comosa enhance fetal hemoglobin production in an erythroid cell line. , 2010, Journal of natural products.

[15]  Atta-ur-rahman,et al.  Oxidation of lynestrenol by the fungus Cunninghamella elegans , 2010, Natural product research.

[16]  Atta-ur-rahman,et al.  Microbial transformation of 18β-glycyrrhetinic acid by Cunninghamella elegans and Fusarium lini, and lipoxygenase inhibitory activity of transformed products , 2009, Natural product research.

[17]  K. Borges,et al.  Stereoselective biotransformations using fungi as biocatalysts , 2009 .

[18]  M. Vidyavathi,et al.  Cunninghamella--a microbial model for drug metabolism studies--a review. , 2009, Biotechnology advances.

[19]  A. Chindaduang,et al.  Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation. , 2008, Bioorganic & medicinal chemistry.

[20]  C. Tonn,et al.  Microbial Hydroxylation of Kudtdiol with Cultures of Cunninghamella Echinulata , 1998 .

[21]  A. Suksamrarn,et al.  A phloracetophenone glucoside with choleretic activity from Curcuma comosa , 1997 .

[22]  O. Giordano,et al.  Hydroxylation of sodic grindelate by Cunninghamella echinulata , 1996 .

[23]  H. Kikuzaki,et al.  Labdane diterpenes from rhizomes of Hedychium coronarium , 1994 .

[24]  M. Akhtar.  Microbial Transformation , 1968, Nature.