Identification of the dichotomous role of age-related LCK in calorie restriction revealed by integrative analysis of cDNA microarray and interactome

[1]  Doris Berger The hunting of the src , 2014, Im Focus Onkologie.

[2]  M. Roizen Association Between Serum Cathepsin S and Mortality in Older Adults , 2012 .

[3]  G. Cagney,et al.  Network Biology , 2011, Methods in Molecular Biology.

[4]  Srinivas Devadas,et al.  CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery , 2010, Proceedings of the National Academy of Sciences.

[5]  E. Giannoni,et al.  Src redox regulation: again in the front line. , 2010, Free radical biology & medicine.

[6]  Don H. Anderson,et al.  The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited , 2010, Progress in retinal and eye research.

[7]  A. Barabasi,et al.  Network medicine : a network-based approach to human disease , 2010 .

[8]  S. Rangaraju,et al.  Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging , 2009, Aging cell.

[9]  David Warde-Farley,et al.  Dynamic modularity in protein interaction networks predicts breast cancer outcome , 2009, Nature Biotechnology.

[10]  J. Collins,et al.  A network biology approach to aging in yeast , 2009, Proceedings of the National Academy of Sciences.

[11]  H. Chung,et al.  Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome , 2008, AGE.

[12]  Y. Higami,et al.  Calorie restriction initiated at a young age activates the Akt/PKCζ/λ-Glut4 pathway in rat white adipose tissue in an insulin-independent manner , 2008, AGE.

[13]  J. Han,et al.  A modular network model of aging , 2007, Molecular systems biology.

[14]  P. Rabinovitch,et al.  Transcriptional response to aging and caloric restriction in heart and adipose tissue , 2007, Aging cell.

[15]  H. Luebbert,et al.  Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells , 2007, Neurobiology of Aging.

[16]  D. Ingram,et al.  Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging , 2007, Neuroscience.

[17]  Mark Gerstein,et al.  The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics , 2007, PLoS Comput. Biol..

[18]  Richard Weindruch,et al.  Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program , 2007, BMC Genomics.

[19]  J. Kang,et al.  Src tyrosine kinases mediate crystalline silica-induced NF-κB activation through tyrosine phosphorylation of IκB-α and p65 NF-κB in raw 264.7 macrophages , 2006 .

[20]  J. Kang,et al.  Src tyrosine kinases mediate crystalline silica-induced NF-kappaB activation through tyrosine phosphorylation of IkappaB-alpha and p65 NF-kappaB in RAW 264.7 macrophages. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[21]  G. Fahy,et al.  Identification of potential caloric restriction mimetics by microarray profiling. , 2005, Physiological genomics.

[22]  D. Sinclair Toward a unified theory of caloric restriction and longevity regulation , 2005, Mechanisms of Ageing and Development.

[23]  T. Kirkwood,et al.  Understanding the Odd Science of Aging , 2005, Cell.

[24]  M. Newman A measure of betweenness centrality based on random walks , 2003, Soc. Networks.

[25]  Jianchun Yu,et al.  Aging-related changes in the transcriptional profile of cerebrum in senescence-accelerated mouse (SAMP10) is remarkably retarded by acupuncture. , 2005, Acupuncture & electro-therapeutics research.

[26]  H. Chung,et al.  Modulation of PPAR in aging, inflammation, and calorie restriction. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[27]  R. N. Harty,et al.  Phospholipid Scramblase 1 Potentiates the Antiviral Activity of Interferon , 2004, Journal of Virology.

[28]  H. Chung,et al.  Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[29]  V. Bohr,et al.  Gene expression profiling in Werner syndrome closely resembles that of normal aging , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Hanno Steen,et al.  Development of human protein reference database as an initial platform for approaching systems biology in humans. , 2003, Genome research.

[31]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[32]  George Coukos,et al.  Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. , 2003, The New England journal of medicine.

[33]  J. Dhahbi,et al.  Protein turnover, energy metabolism, aging, and caloric restriction , 2003 .

[34]  Byung Pal Yu,et al.  Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction , 2002, Microscopy research and technique.

[35]  Richard Weindruch,et al.  Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[36]  M. Mcdaniel,et al.  Identifying the links between obesity, insulin resistance and β‐cell function: potential role of adipocyte‐derived cytokines in the pathogenesis of type 2 diabetes , 2002, European journal of clinical investigation.

[37]  S. Goto,et al.  Dietary Restriction Initiated in Late Adulthood Can Reverse Age‐related Alterations of Protein and Protein Metabolism , 2002, Annals of the New York Academy of Sciences.

[38]  S. Levin,et al.  Lck plays a critical role in Ca2+ mobilization and CD28 costimulation in mature primary T cells , 2001, European journal of immunology.

[39]  S. Ratnofsky,et al.  Lck inhibitors as a therapeutic approach to autoimmune disease and transplant rejection. , 2001, Current opinion in investigational drugs.

[40]  Martin Gs The hunting of the Src. , 2001 .

[41]  A. Barabasi,et al.  Lethality and centrality in protein networks , 2001, Nature.

[42]  R. Tibshirani,et al.  Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[43]  J. Halter,et al.  Caloric restriction mimetics: metabolic interventions. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[44]  G. Legname,et al.  Long-term survival but impaired homeostatic proliferation of Naïve T cells in the absence of p56lck. , 2000, Science.

[45]  D. Morgan,et al.  Inflammatory Processes: , 2000, Progress in Inflammation Research.

[46]  R. Weindruch,et al.  Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. , 1999, Cancer research.

[47]  B. Yu,et al.  Aging and oxidative stress: modulation by dietary restriction. , 1996, Free radical biology & medicine.

[48]  J. Hardwick,et al.  Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[49]  W. Lynn,et al.  Does food restriction retard aging by reducing metabolic rate? , 1992, The Journal of nutrition.

[50]  Arthur Weiss,et al.  Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor , 1992, Cell.

[51]  A. Wakeham,et al.  Profound block in thymocyte development in mice lacking p56lck , 1992, Nature.

[52]  K. M. Abraham,et al.  Thymic tumorigenesis induced by overexpression of p56lck. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[53]  B. Yu,et al.  The influence of dietary protein source on longevity and age-related disease processes of Fischer rats. , 1988, Journal of gerontology.

[54]  M. Kaplan,et al.  Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. , 1980, The American journal of physiology.