Sesquiterpene Coumarins from Ferula Foetida

A thorough investigation of the ethyl acetate soluble fraction from a methanol extract of the resin of Ferula foetida has resulted in the isolation of a new sesquiterpene coumarin namely epi-conferdione (1), along with four known compounds, colladonin (2), karatavicinol (3), 8-acetoxy-5-hydroxyumbelliprenin (4), and asacoumarin (5). These structures were elucidated on the basis of extensive spectroscopic techniques, including 1D and 2D NMR spectroscopy. The absolute configuration of the new compound was established by circular dichroism (CD).

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