Lesion‐directed treatment for actinic keratoses

containing local anaesthetic or the topical use of vasodilator agents affects outcomes in FTSG repair. Whether FTSGs that do span the entire alar unit are less prone to pincushioning without the need for postoperative intervention, or whether the use of synthetic collagen matrix materials (dermal substitutes) are superior to muscular/cutaneous hinge flaps or even delayed grafting are some of the questions pertaining to ala reconstruction that are yet to be answered in randomized controlled trials. The authors of this current series are to be commended for their work.

[1]  B. Dréno,et al.  Management of actinic keratosis: a practical report and treatment algorithm from AKTeamTM expert clinicians , 2014, Journal of the European Academy of Dermatology and Venereology : JEADV.

[2]  P. Salmon,et al.  Full‐thickness skin grafts for surgical defects of the nasal ala – a comprehensive review, approach and outcomes of 186 cases over 9 years , 2014, The British journal of dermatology.

[3]  B. Ortel,et al.  Cryotherapy is preferable to ablative CO2 laser for the treatment of isolated actinic keratoses of the face and scalp: a randomized clinical trial , 2014, The British journal of dermatology.

[4]  T. Gambichler,et al.  A randomized, half‐side comparative study of aminolaevulinate photodynamic therapy vs. CO2 laser ablation in immunocompetent patients with multiple actinic keratoses , 2012, The British journal of dermatology.

[5]  J. Hafiji,et al.  Optimizing adherence of full‐thickness skin grafts to the wound bed of the nasal ala with the ‘sandwich suture’ , 2012, The British journal of dermatology.

[6]  W. Hussain,et al.  A ‘D.I.Y.’ nasal plug with airway: an alternative approach , 2010, The British journal of dermatology.

[7]  C. Flohr,et al.  Merocel® nasal packing with airway: a method to help secure full‐thickness skin grafts on the nasal tip , 2010, The British journal of dermatology.

[8]  N. Kerrouche,et al.  Multicentre intraindividual randomized trial of topical methyl aminolaevulinate–photodynamic therapy vs. cryotherapy for multiple actinic keratoses on the extremities , 2008, The British journal of dermatology.

[9]  J. McGregor,et al.  Guidelines for the management of actinic keratoses , 2007, The British journal of dermatology.

[10]  Cynthia C. Morton,et al.  Intraindividual, right–left comparison of topical methyl aminolaevulinate‐photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicentre, randomized controlled study , 2006, The British journal of dermatology.

[11]  H. Kerl,et al.  Guidelines for the management of actinic keratoses. , 2006, European journal of dermatology : EJD.

[12]  Murad Alam,et al.  Clinical Appearance of Full‐Thickness Skin Grafts of the Nose , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[13]  D. Murrell,et al.  A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix®) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study , 2003, The Journal of dermatological treatment.

[14]  R. M. Szeimiesa,et al.  Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. , 2002 .

[15]  D. Salomon,et al.  Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. , 2002, Journal of the American Academy of Dermatology.

[16]  D. Brodland,et al.  A Single Postoperative Application of Nitroglycerin Ointment Does Not Increase Survival of Cutaneous Flaps and Grafts , 2000, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[17]  R. Bracaglia,et al.  Analysis of infiltrating epitheliomas of the nose examined from 1986 to 1995. , 1998, The Journal of otolaryngology.

[18]  J. Zitelli,et al.  Full-thickness skin grafts. Clinical observations on the impact of using epinephrine in local anesthesia of the donor site. , 1995, Archives of dermatology.

[19]  F. Urbach,et al.  Incidence of nonmelanoma skin cancer. , 1991, Dermatologic clinics.

[20]  G. Rennie,et al.  MALIGNANT TRANSFORMATION OF SOLAR KERATOSES TO SQUAMOUS CELL CARCINOMA , 1988, The Lancet.

[21]  J. Zitelli Wound healing by secondary intention. A cosmetic appraisal. , 1983, Journal of the American Academy of Dermatology.

[22]  T. P. Eddy Letter: Atmospheric ozone and femoral fractures. , 1975, Lancet.