JNK2 is a positive regulator of the cJun transcription factor.

[1]  Chao Zhang,et al.  Chemical genetic analysis of the time course of signal transduction by JNK. , 2006, Molecular cell.

[2]  A. Fanning Faculty Opinions recommendation of p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. , 2005 .

[3]  Kevan M Shokat,et al.  Features of selective kinase inhibitors. , 2005, Chemistry & biology.

[4]  Xi Chen,et al.  A Chemical-Genetic Approach to Studying Neurotrophin Signaling , 2005, Neuron.

[5]  M. Goedert,et al.  p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP , 2005, The EMBO journal.

[6]  J. Molkentin,et al.  MEKK1 Transduces Activin Signals in Keratinocytes To Induce Actin Stress Fiber Formation and Migration , 2005, Molecular and Cellular Biology.

[7]  R. Flavell,et al.  JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. , 2004, Genes & development.

[8]  石井 誠 c-Jun NH_2-terminal kinase の抑制はラット肺の虚血再灌流傷害を改善する , 2004 .

[9]  E. Wagner,et al.  JNK2: A Negative Regulator of Cellular Proliferation , 2004, Cell cycle.

[10]  Ken Jacobson,et al.  MAP kinases and cell migration , 2004, Journal of Cell Science.

[11]  E. Wagner,et al.  Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. , 2004, Molecular cell.

[12]  Z. Ronai JNKing Revealed. , 2004, Molecular cell.

[13]  Chao Zhang,et al.  Bypassing a Kinase Activity with an ATP-Competitive Drug , 2003, Science.

[14]  Anthony C. Bishop,et al.  Specific Inhibition of Elm1 Kinase Activity Reveals Functions Required for Early G1 Events , 2003, Molecular and Cellular Biology.

[15]  Chao Zhang,et al.  Cutting Edge: A Chemical Genetic System for the Analysis of Kinases Regulating T Cell Development 1 , 2003, The Journal of Immunology.

[16]  T. Jacks,et al.  Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry , 2003, Nature.

[17]  A. Manning,et al.  Targeting JNK for therapeutic benefit: from junk to gold? , 2003, Nature Reviews Drug Discovery.

[18]  R. Flavell,et al.  JunD mediates survival signaling by the JNK signal transduction pathway. , 2003, Molecular cell.

[19]  R. Flavell,et al.  c-Jun NH2-Terminal Kinase Is Essential for the Regulation of AP-1 by Tumor Necrosis Factor , 2003, Molecular and Cellular Biology.

[20]  Joe Z Tsien,et al.  Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Chao Zhang,et al.  Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. , 2003, Molecular biology of the cell.

[22]  C. Weston,et al.  The JNK signal transduction pathway. , 2007, Current opinion in genetics & development.

[23]  K. Shokat,et al.  Novel chemical genetic approaches to the discovery of signal transduction inhibitors. , 2002, Drug discovery today.

[24]  David W. Anderson,et al.  SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Anthony C. Bishop,et al.  Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A L Burlingame,et al.  Identification of New JNK Substrate Using ATP Pocket Mutant JNK and a Corresponding ATP Analogue* , 2001, The Journal of Biological Chemistry.

[27]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[28]  Anthony C. Bishop,et al.  Magic bullets for protein kinases. , 2001, Trends in cell biology.

[29]  R. Davis,et al.  Analyzing JNK and p38 mitogen-activated protein kinase activity. , 2001, Methods in enzymology.

[30]  H. Larjava,et al.  An improved method for culture of epidermal keratinocytes from newborn mouse skin. , 2001, Methods in cell science : an official journal of the Society for In Vitro Biology.

[31]  R. Davis,et al.  Signal Transduction by the JNK Group of MAP Kinases , 2000, Cell.

[32]  Kevan M. Shokat,et al.  Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p , 2000, Nature Cell Biology.

[33]  Peter G. Schultz,et al.  A chemical switch for inhibitor-sensitive alleles of any protein kinase , 2000, Nature.

[34]  D. Bar-Sagi,et al.  Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. , 2000, Science.

[35]  Y. Yarden,et al.  Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway , 2000, Molecular and Cellular Biology.

[36]  K. Shokat,et al.  Acquisition of inhibitor-sensitive protein kinases through protein design. , 1999, Pharmacology & therapeutics.

[37]  J. Brugge,et al.  pp60v- src Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways , 1999, The Journal of Biological Chemistry.

[38]  Richard J. Lee,et al.  pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells. , 1999, The Journal of biological chemistry.

[39]  R. Flavell,et al.  Defective T cell differentiation in the absence of Jnk1. , 1998, Science.

[40]  R. Flavell,et al.  Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. , 1998, Immunity.

[41]  M. Yaniv,et al.  Stress‐activated protein kinases are negatively regulated by cell density , 1998, The EMBO journal.

[42]  V. Fried,et al.  Stress-activated kinases regulate protein stability , 1998, Oncogene.

[43]  V. Fried,et al.  c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors* , 1997, The Journal of Biological Chemistry.

[44]  Dirk Bohmann,et al.  Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases , 1997, Science.

[45]  H. K. Sluss,et al.  Selective interaction of JNK protein kinase isoforms with transcription factors. , 1996, The EMBO journal.

[46]  I. Tsigelny,et al.  JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. , 1994, Genes & development.

[47]  H. K. Sluss,et al.  Signal transduction by tumor necrosis factor mediated by JNK protein kinases , 1994, Molecular and cellular biology.

[48]  B. Spiegelman,et al.  A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. , 1993, Genes & development.