Dendritic changes in Alzheimer's disease and factors that may underlie these changes

[1]  T. Ohm,et al.  The effects of β/A4-amyloid and its fragments on calcium homeostasis, glial fibrillary acidic protein and S100β staining, morphology and survival of cultured hippocampal astrocytes , 1998, Neuroscience.

[2]  C. Miller,et al.  Neuropathological Abnormalities in Transgenic Mice Harbouring a Phosphorylation Mutant Neurofilament Transgene , 1998, Journal of neurochemistry.

[3]  G. Jicha,et al.  A Conformation‐ and Phosphorylation‐Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease , 1997, Journal of neurochemistry.

[4]  Veeranna,et al.  Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5) , 1997, Brain Research.

[5]  A. Nebreda,et al.  Reactivating Kinase/p38 Phosphorylates τ Protein In Vitro , 1997 .

[6]  J. Julien,et al.  Neurofilaments and motor neuron disease. , 1997, Trends in cell biology.

[7]  J. Bohl,et al.  Decrease in Adenylate Cyclase Activity Antecedes Neurofibrillary Tangle Formation , 1997, Neurobiology of Aging.

[8]  U. Wagner,et al.  Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly. , 1997, The Biochemical journal.

[9]  S. Lovestone,et al.  The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes. , 1997, Neuroscience.

[10]  G. Drewes,et al.  MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption , 1997, Cell.

[11]  G. Jicha,et al.  Alz‐50 and MC‐1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau , 1997, Journal of neuroscience research.

[12]  M. Gurney,et al.  Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[13]  B. Anderton,et al.  Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein , 1997, Journal of neurochemistry.

[14]  J. Wegiel,et al.  Relationships between Regional Neuronal Loss and Neurofibrillary Changes in the Hippocampal Formation and Duration and Severity of Alzheimer Disease , 1997, Journal of neuropathology and experimental neurology.

[15]  R. Brandt,et al.  Conversion of Serine to Aspartate Imitates Phosphorylation-induced Changes in the Structure and Function of Microtubule-associated Protein Tau* , 1997, The Journal of Biological Chemistry.

[16]  G. Šimić,et al.  Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease , 1997, The Journal of comparative neurology.

[17]  E. Mandelkow,et al.  The 'jaws' model of tau-microtubule interaction examined in CHO cells. , 1997, Journal of cell science.

[18]  D. Borchelt,et al.  ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions , 1997, Neuron.

[19]  Thomas Arendt,et al.  Plastic Neuronal Remodeling Is Impaired in Patients with Alzheimer’s Disease Carrying Apolipoprotein ε4 Allele , 1997, The Journal of Neuroscience.

[20]  E. Koo,et al.  Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. , 1997, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[21]  J. Kuret,et al.  The Structural Basis of Monoclonal Antibody Alz50's Selectivity for Alzheimer's Disease Pathology* , 1996, The Journal of Biological Chemistry.

[22]  C. Giménez,et al.  Transcription Factor AP-2 Regulates Human Apolipoprotein E Gene Expression in Astrocytoma Cells , 1996, The Journal of Neuroscience.

[23]  L. Frölich,et al.  Reduced immunoreactivity of adenylyl cyclase in dementia of the Alzheimer type , 1996, Neuroreport.

[24]  J. Gallo,et al.  Aggregation of Neurofilaments in NF‐L Transfected Neuronal Cells: Regeneration of the Filamentous Network by a Protein Kinase C Inhibitor , 1996, Journal of neurochemistry.

[25]  T. Crawford,et al.  Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport , 1996, The Journal of cell biology.

[26]  L. Bruijn,et al.  Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease , 1996, Neuropathology and applied neurobiology.

[27]  C. Masters,et al.  The beta‐amyloid domain is essential for axonal sorting of amyloid precursor protein. , 1996, The EMBO journal.

[28]  S. Lovestone,et al.  Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules , 1996, Neuroscience.

[29]  J. Morris,et al.  Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease , 1996, The Journal of Neuroscience.

[30]  T. Taniguchi,et al.  Ca2+‐Dependent and Ca2+‐Independent Protein Kinase C Changes in the Brains of Patients with Alzheimer's Disease , 1996, Journal of neurochemistry.

[31]  R. Nitsch,et al.  Long‐lasting Transneuronal Changes in Rat Dentate Granule Cell Dendrites after Entorhinal Cortex Lesion. A Combined Intracellular Injection and Electron Microscopy Study , 1996, Brain pathology.

[32]  U. Wagner,et al.  Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. , 1996, Journal of cell science.

[33]  E. Kandel,et al.  A Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation Requiring cAMP in the Medial Perforant Pathway of Rat Hippocampal Slices , 1996, The Journal of Neuroscience.

[34]  S. Lovestone,et al.  The intracellular fate of apolipoprotein E is tau dependent and apoe allelespecific , 1996 .

[35]  R. Crowther,et al.  Characterization of mAb AP422, a novel phosphorylation‐dependent monoclonal antibody against tau protein , 1996 .

[36]  K. Imahori,et al.  Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[37]  M. Gurney,et al.  Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. Hanger,et al.  Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase mos , 1996, Neurobiology of Aging.

[39]  R. Powers,et al.  Effects of postmortem interval, age, and Alzheimer's disease on G-proteins in human brain , 1996, Neurobiology of Aging.

[40]  W. Engel,et al.  Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[41]  P. Davies,et al.  Mitotic mechanisms in Alzheimer's disease? , 1996, The Journal of cell biology.

[42]  Guy A. Rouleau,et al.  SOD1 mutation is assosiated with accumulation of neurofilaments in amyotrophic lateral scelaries , 1996 .

[43]  M. Trabucchi,et al.  Defective Protein Kinase C α Leads to Impaired Secretion of Soluble β‐Amyloid Precursor Protein from Alzheimer's Disease Fibroblasts a , 1996 .

[44]  E. Mandelkow,et al.  Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. , 1995, Molecular biology of the cell.

[45]  C. Fages,et al.  Apolipoprotein E gene expression in astrocytes: developmental pattern and regulation , 1995, Neuroreport.

[46]  J. Woodgett,et al.  Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement. , 1995, Brain research. Molecular brain research.

[47]  J. Morrison,et al.  Intraperikaryal Neurofilamentous Accumulations in a Subset of Retinal Ganglion Cells in Aged Mice That Express a Human Neurofilament Gene , 1995, Experimental Neurology.

[48]  R. Powers,et al.  Phosphoinositide hydrolysis, Gαq, phospholipase C, and protein kinase C in post mortem human brain: Effects of post mortem interval, subject age, and alzheimer's disease , 1995, Neuroscience.

[49]  P. Davies,et al.  Binding of Alz 50 depends on Phe8 in tau synthetic peptides and varies between native and denatured tau proteins , 1995, Brain Research.

[50]  M. Goedert,et al.  Glycogen synthase kinase-3β phosphorylates tau protein at multiple sites in intact cells , 1995, Neuroscience Letters.

[51]  T. Crawford,et al.  Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons , 1995, The Journal of cell biology.

[52]  L. Descarries,et al.  Abnormal perikaryal accumulation of neurofilament light protein in the brain of mice transgenic for the human protein: Sequence of postnatal development , 1995, Neuroscience.

[53]  J. Trojanowski,et al.  Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau (*) , 1995, The Journal of Biological Chemistry.

[54]  C. Miller,et al.  The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures. , 1995, The Biochemical journal.

[55]  G. Johnson,et al.  Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP. , 1995, The Biochemical journal.

[56]  J. Trojanowski,et al.  Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits , 1995, The Journal of cell biology.

[57]  D. Borchelt,et al.  An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria , 1995, Neuron.

[58]  W. März,et al.  Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation , 1995, Neuroscience.

[59]  S. Lovestone,et al.  Stimulation of MAP kinase by v‐raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau , 1995, FEBS letters.

[60]  H. Sorimachi,et al.  Conventional protein kinase C (PKC)‐α and novel PKCε, but not ‐δ, increase the secretion of an N‐terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts , 1995 .

[61]  W. Honer,et al.  Correlations of synaptic and pathological markers with cognition of the elderly , 1995, Neurobiology of Aging.

[62]  E. Ikonen,et al.  Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites , 1995, Journal of neuroscience research.

[63]  P. Coleman,et al.  Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease , 1995, Neurobiology of Aging.

[64]  D. Selkoe,et al.  Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons , 1995, The Journal of cell biology.

[65]  M. Goedert,et al.  Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. , 1995, The EMBO journal.

[66]  R. Mahley,et al.  Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease , 1995, Current opinion in lipidology.

[67]  S. Yang,et al.  Protein Kinase FA/Glycogen Synthase Kinase 3α Predominantly Phosphorylates the In Vivo Sites of Ser502, Ser506, Ser603, and Ser666 in Neurofilament , 1995, Journal of neurochemistry.

[68]  E. Mandelkow,et al.  Microtubule-associated Protein/Microtubule Affinity-regulating Kinase (p110mark) , 1995, The Journal of Biological Chemistry.

[69]  V. Ingram,et al.  Activation of a neurofilament kinase, a tau kinase, and a tau phosphatase by decreased ATP levels in nerve growth factor-differentiated PC-12 cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[70]  Idan Segev,et al.  The morphoelectrotonic transform: a graphical approach to dendritic function , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[71]  L. Descarries,et al.  CNS distribution and overexpression of neurofilament light proteins (NF-L) in mice transgenic for the human NF-L: Aberrant accumulation in thalamic perikarya , 1995, Experimental Neurology.

[72]  R. Ravid,et al.  Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease , 1995, Neuroscience Letters.

[73]  B. Winblad,et al.  Preservation of κ 1 opioid receptor recognition site density and regulation by G-proteins in the temporal cortex of patients with Alzheimer's disease , 1995, Neuroscience Letters.

[74]  J. Morrison,et al.  Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[75]  H. Braak,et al.  Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes , 1995, Neuroscience.

[76]  K. Titani,et al.  Proline-directed and Non-proline-directed Phosphorylation of PHF-tau (*) , 1995, The Journal of Biological Chemistry.

[77]  John W. Miller,et al.  Denervation induced abnormal phosphorylation in hippocampal neurons , 1995, Brain Research.

[78]  J. Trojanowski,et al.  τ Phosphorylation in Human, Primate, and Rat Brain: Evidence that a Pool of τ Is Highly Phosphorylated In Vivo and Is Rapidly Dephosphorylated In Vitro , 1994, Journal of neurochemistry.

[79]  J. Brion,et al.  Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons , 1994, Neuroscience.

[80]  Simon Lovestone,et al.  Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells , 1994, Current Biology.

[81]  J. Joseph,et al.  Area specific alterations in muscarinic stimulated low K m GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction , 1994, Brain Research.

[82]  V. Meininger,et al.  Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. , 1994, Human molecular genetics.

[83]  J. Trojanowski,et al.  Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau , 1994, Neuron.

[84]  D. Cleveland,et al.  A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease , 1994, Neuron.

[85]  E. Mandelkow,et al.  Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure. , 1994, The Journal of biological chemistry.

[86]  J. Troncoso,et al.  Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease , 1994, The Lancet.

[87]  R. Lazzarini,et al.  Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[88]  R. Buranosky,et al.  Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[89]  U. Heinemann,et al.  Long lasting functional alterations in the rat dentate gyrus following entorhinal cortex lesion: A current source density analysis , 1994, Neuroscience.

[90]  M. Gurney,et al.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.

[91]  Hoau Yan Wang,et al.  Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients , 1994, Neuroscience Letters.

[92]  J. Bohl,et al.  Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected , 1994, Brain Research.

[93]  P. Coleman,et al.  Preliminary evidence: Decreased GAP-43 message in tangle-bearing neurons relative to adjacent tangle-free neurons in Alzheimer's disease parahippocampal gyrus , 1994, Neurobiology of Aging.

[94]  V. Ingram,et al.  Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's disease. , 1994, Biochemical and biophysical research communications.

[95]  R. Powers,et al.  Impaired phosphoinositide hydrolysis in Alzheimer's disease brain , 1994, Neurobiology of Aging.

[96]  C. Léránth,et al.  Long-lasting transneuronal dendritic changes of GABAergic neurons in the monkey dentate gyrus following entorhinal cortex lesion , 1994, Neuroscience Letters.

[97]  J. Prestle,et al.  PKCu is a novel, atypical member of the protein kinase C family. , 1994, The Journal of biological chemistry.

[98]  B. Winblad,et al.  Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain , 1994, Brain Research.

[99]  A. Peterson,et al.  Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-β-galactosidase fusion protein , 1994, Neuron.

[100]  K. Titani,et al.  In vivo phosphorylation sites in fetal and adult rat tau. , 1993, The Journal of biological chemistry.

[101]  E. Mandelkow,et al.  Tau as a marker for Alzheimer's disease. , 1993, Trends in biochemical sciences.

[102]  J. Brion,et al.  Developmental Changes in τ Phosphorylation: Fetal τ Is Transiently Phosphorylated in a Manner Similar to Paired Helical Filament‐τ Characteristic of Alzheimer's Disease , 1993, Journal of neurochemistry.

[103]  S. Yen,et al.  The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments , 1993, Brain Research.

[104]  J. H. Wang,et al.  Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments. , 1993, The Journal of biological chemistry.

[105]  L. Cork,et al.  Alterations in neurofilament mRNA in hereditary canine spinal muscular atrophy. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[106]  T. Ohm Alterations of signal transduction in the lesioned entorhinal—hippocampal system: A mini‐review on alzheimer's disease‐related changes and experimental data , 1993, Hippocampus.

[107]  R. Nitsch Transneuronal changes in the lesioned entorhinal—hippocampal system , 1993, Hippocampus.

[108]  A. D. Roses,et al.  Association of apolipoprotein E allele €4 with late-onset familial and sporadic Alzheimer’s disease , 2006 .

[109]  G. Gibson,et al.  Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors. , 1993, The Journal of biological chemistry.

[110]  Mark J. West,et al.  Regionally specific loss of neurons in the aging human hippocampus , 1993, Neurobiology of Aging.

[111]  S. Gauthier,et al.  Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats , 1993, Neuroscience.

[112]  V. Ingram,et al.  Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease. , 1993, Biochemical and biophysical research communications.

[113]  B. Winblad,et al.  Disrupted β1-adrenoceptor—G protein coupling in the temporal cortex of patients with Alzheimer's disease , 1993, Neuroscience Letters.

[114]  K. Titani,et al.  Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments , 1993, Journal of neurochemistry.

[115]  John Q. Trojanowski,et al.  Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding , 1993, Neuron.

[116]  O. Jacobowitz,et al.  Signal recognition and integration by GS-stimulated adenylyl cyclases , 1993, Current Opinion in Neurobiology.

[117]  J. Julien,et al.  Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis , 1993, Cell.

[118]  L. Cork,et al.  Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease , 1993, Cell.

[119]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[120]  A. Nordberg,et al.  Coupling of muscarinic receptors to GTP proteins in postmortem human brain — alterations in Alzheimer's disease , 1993, Neuroscience Letters.

[121]  C. W. Scott,et al.  Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly. , 1993, The Journal of biological chemistry.

[122]  Mark P. Mattson,et al.  Calcium as sculptor and destroyer of neural circuitry , 1992, Experimental Gerontology.

[123]  J. Woodgett,et al.  Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase , 1992, Neuroscience Letters.

[124]  N. Hirokawa,et al.  Microtubule bundling by tau proteins in vivo: analysis of functional domains. , 1992, The EMBO journal.

[125]  Y. Nishizuka Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. , 1992, Science.

[126]  K. Kosik,et al.  Suppression of MAP2 in cultured cerebeller macroneurons inhibits minor neurite formation , 1992, Neuron.

[127]  K. Titani,et al.  Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain. , 1992, The Journal of biological chemistry.

[128]  B. Winblad,et al.  Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease , 1992, Neuroscience Letters.

[129]  T. Taniguchi,et al.  Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease , 1992, Brain Research.

[130]  B. Winblad,et al.  Adenylyl Cyclase Activity in Postmortem Human Brain: Evidence of Altered G Protein Mediation in Alzheimer's Disease , 1992, Journal of neurochemistry.

[131]  P. Davies,et al.  A protein kinase associated with paired helical filaments in Alzheimer disease. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[132]  R. Pittman,et al.  Competitive regulation of phospholipase C responses by cAMP and calcium. , 1992, Molecular pharmacology.

[133]  G. Johnson,et al.  Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain. , 1992, The Journal of biological chemistry.

[134]  P. Davies,et al.  Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. , 1992, The Journal of biological chemistry.

[135]  B. Winblad,et al.  Preservation of 5-hydroxytryptamine1A receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease , 1991, Neuroscience Letters.

[136]  HM Roder,et al.  Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[137]  B. Winblad,et al.  Coupling of human brain cerebral cortical α 2-adrenoceptors to GTP-binding proteins in Alzheimer's disease , 1991, Brain Research.

[138]  T. Taniguchi,et al.  Aberrant accumulation of phospholipase C-delta in Alzheimer brains. , 1991, The American journal of pathology.

[139]  D. Salmon,et al.  Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment , 1991, Annals of neurology.

[140]  B. Winblad,et al.  Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase activity in Alzheimer's disease brain , 1991, Journal of the Neurological Sciences.

[141]  P. Roach,et al.  Multisite and hierarchal protein phosphorylation. , 1991, The Journal of biological chemistry.

[142]  K. Kosik,et al.  Overexpression of tau in a nonneuronal cell induces long cellular processes , 1991, The Journal of cell biology.

[143]  J. Mcculloch,et al.  Robustness of G Proteins in Alzheimer's Disease: An Immunoblot Study , 1991, Journal of neurochemistry.

[144]  E. Kandel,et al.  cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[145]  M. Goedert,et al.  Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau , 1991, Neuroscience Letters.

[146]  E. Masliah,et al.  Protein kinases and phosphorylation in neurologic disorders and cell death. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[147]  Paul J. Harrison,et al.  Alzheimer's disease: specific increases in a G protein subunit (Gs alpha) mRNA in hippocampal and cortical neurons. , 1991, Brain research. Molecular brain research.

[148]  D. Mash,et al.  Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies , 1991, Annals of neurology.

[149]  D. Flood,et al.  Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus , 1991, Brain Research.

[150]  J. Bohl,et al.  Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes , 1991, Brain Research.

[151]  D. Flood Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. II. Subiculum , 1991, Brain Research.

[152]  G. V. Vande Woude,et al.  Neuropathological changes in transgenic mice carrying copies of a transcriptionally activated Mos protooncogene , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[153]  P. Davies,et al.  Phosphorylation characteristics of the A68 protein in Alzheimer's disease , 1990, Brain Research.

[154]  J. Gearhart,et al.  Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber , 1990, The Journal of cell biology.

[155]  E. Masliah,et al.  Differential involvement of protein kinase C isozymes in Alzheimer's disease , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[156]  K. Kosik,et al.  Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons , 1990, Nature.

[157]  R. Liem Neuronal intermediate filaments. , 1990, Current opinion in cell biology.

[158]  S. Chin,et al.  Expression of rat neurofilament proteins NF-L and NF-M in transfected non-neuronal cells. , 1989, European journal of cell biology.

[159]  R. Katzman.,et al.  Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. , 1989, Archives of neurology.

[160]  R. A. Crowther,et al.  Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease , 1989, Neuron.

[161]  J. Brion,et al.  Accumulation of smooth endoplasmic reticulum in Alzheimer's disease: new morphological evidence of axoplasmic flow disturbances. , 1989, Journal of submicroscopic cytology and pathology.

[162]  Kenneth S. Kosik,et al.  Developmentally regulated expression of specific tau sequences , 1989, Neuron.

[163]  K. Dobkins,et al.  Decreased levels of protein kinase C in Alzheimer brain , 1988, Brain Research.

[164]  R. Mahley,et al.  Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.

[165]  Paul D. Coleman,et al.  Neuron numbers and dendritic extent in normal aging and Alzheimer's disease , 1987, Neurobiology of Aging.

[166]  Kenneth R. Brizzee,et al.  Neuron numbers and dendritic extent in normal aging and alzheimer's disease , 1987, Neurobiology of Aging.

[167]  P. Coleman,et al.  Dendritic extent in human CA2–3 hippocampal pyramidal neurons in normal aging and senile dementia , 1987, Brain Research.

[168]  M. Paula-Barbosa,et al.  ALZHEIMER'S DISEASE: PAIRED HELICAL FILAMENTS AND CYTOMEMBRANES , 1987, Neuropathology and applied neurobiology.

[169]  H. B. M. Uylings,et al.  Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia , 1987, Brain Research.

[170]  P. Coleman,et al.  Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia , 1987, Brain Research.

[171]  R. Mahley,et al.  Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. , 1987, Biochimica et biophysica acta.

[172]  D. Dickson,et al.  A neuronal antigen in the brains of Alzheimer patients. , 1986, Science.

[173]  E. Shooter,et al.  Expression of apolipoprotein E during nerve degeneration and regeneration. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[174]  C. Cotman,et al.  Plasticity of hippocampal circuitry in Alzheimer's disease. , 1985, Science.

[175]  Elmer S. West From the U. S. A. , 1965 .

[176]  A. Nebreda,et al.  Reactivating kinase/p38 phosphorylates tau protein in vitro. , 1997, Journal of neurochemistry.

[177]  H. Braak,et al.  Staging of Alzheimer-related cortical destruction. , 1997, International psychogeriatrics.

[178]  K. Iqbal,et al.  Alzheimer's disease : biology, diagnosis, and therapeutics , 1996 .

[179]  A. Clark,et al.  SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis. , 1996, Annals of neurology.

[180]  K. Suzuki,et al.  Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts. , 1995, FEBS letters.

[181]  T. Taniguchi,et al.  Differential involvement of phospholipase C isozymes in Alzheimer's disease. , 1995, Gerontology.

[182]  E. Mandelkow,et al.  Microtubules and microtubule-associated proteins. , 1995, Current opinion in cell biology.

[183]  T. Huang,et al.  PROTEIN-KINASE F-A/GLYCOGEN SYNTHASE KINASE 3-ALPHA PREDOMINANTLY PHOSPHORYLATES THE IN-VIVO SITES OF SER(502), SER(506), SER(603), AND SER(666) IN NEUROFILAMENT , 1995 .

[184]  D. Flynn,et al.  Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease. , 1993, Life sciences.

[185]  R. Bridges,et al.  Prior parity reduces post-coital diurnal and nocturnal prolactin surges in rats. , 1993, Life sciences.

[186]  L. Bierer,et al.  Reduced in vitro phosphorylation of synapsin I (site 1) in Alzheimer's disease postmortem tissues. , 1991, Brain research. Molecular brain research.

[187]  J. Bohl,et al.  REDUCED CAMP‐SIGNAL TRANSDUCTION IN POSTMORTEM HIPPOCAMPUS OF DEMENTED OLD PEOPLE , 1989, Progress in clinical and biological research.

[188]  H. Lodish Molecular Cell Biology , 1986 .

[189]  J. Taylor,et al.  Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. , 1985, Proceedings of the National Academy of Sciences of the United States of America.