Animal models for arrhythmias.

[1]  Shien-Fong Lin,et al.  Mechanisms of Atrial Fibrillation , 2003, Journal of cardiovascular electrophysiology.

[2]  S. Priori,et al.  Bidirectional Ventricular Tachycardia and Fibrillation Elicited in a Knock-In Mouse Model Carrier of a Mutation in the Cardiac Ryanodine Receptor , 2005, Circulation research.

[3]  S. Nattel,et al.  Mechanisms of atrial remodeling and clinical relevance , 2005, Current opinion in cardiology.

[4]  S. Varnous,et al.  Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies. , 2005, Human molecular genetics.

[5]  J. Ruskin,et al.  Integration of cardiac magnetic resonance imaging with three-dimensional electroanatomic mapping to guide left ventricular catheter manipulation: feasibility in a porcine model of healed myocardial infarction. , 2004, Journal of the American College of Cardiology.

[6]  Jingdong Li,et al.  Transgenic upregulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability. , 2004, American journal of physiology. Heart and circulatory physiology.

[7]  A. Moorman,et al.  Architectural plan for the heart: early patterning and delineation of the chambers and the nodes. , 2004, Trends in cardiovascular medicine.

[8]  Walter Birchmeier,et al.  Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy , 2004, Nature Genetics.

[9]  T. Jentsch,et al.  Ion channels: Function unravelled by dysfunction , 2004, Nature Cell Biology.

[10]  W. Birchmeier,et al.  Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation , 2004, The Journal of cell biology.

[11]  W. Haefeli,et al.  Voriconazole-induced QT interval prolongation and ventricular tachycardia: a non-concentration-dependent adverse effect. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  M. Casimiro,et al.  Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans. , 2004, Genomics.

[13]  M. Capecchi,et al.  Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. , 2004, The American journal of pathology.

[14]  C. Baty Feline hypertrophic cardiomyopathy: an update. , 2004, The Veterinary clinics of North America. Small animal practice.

[15]  Sander Verheule,et al.  Increased Vulnerability to Atrial Fibrillation in Transgenic Mice With Selective Atrial Fibrosis Caused by Overexpression of TGF-β1 , 2004, Circulation research.

[16]  Carlo Napolitano,et al.  A cardiac arrhythmia syndrome caused by loss of ankyrin-B function , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[17]  J. Nerbonne Studying cardiac arrhythmias in the mouse--a reasonable model for probing mechanisms? , 2004, Trends in cardiovascular medicine.

[18]  C. Antzelevitch,et al.  Autonomic aspects of arrhythmogenesis: the enduring and the new , 2004, Current opinion in cardiology.

[19]  G. Koren Electrical remodeling and arrhythmias in long‐QT syndrome: lessons from genetic models in mice , 2004, Annals of medicine.

[20]  José Jalife,et al.  Experimental and Clinical AF Mechanisms: Bridging the Divide , 2003, Journal of Interventional Cardiac Electrophysiology.

[21]  Paul J. Wang,et al.  Cardiac Conduction Abnormalities in a Mouse Model of Lyme Borreliosis , 2001, Journal of Interventional Cardiac Electrophysiology.

[22]  Giuseppe Curigliano,et al.  Drug-induced prolongation of the QT interval. , 2004, The New England journal of medicine.

[23]  H. Niemann,et al.  Application of transgenesis in livestock for agriculture and biomedicine. , 2003, Animal reproduction science.

[24]  Gabriele Vacun,et al.  Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. , 2003, Toxicology and applied pharmacology.

[25]  M. Biel,et al.  The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[26]  J. Seidman,et al.  Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome. , 2003, Journal of the American College of Cardiology.

[27]  S. Taffet,et al.  High Incidence of Cardiac Malformations in Connexin40-Deficient Mice , 2003, Circulation research.

[28]  A. Waldo Inter‐Relationships Between Atrial Flutter and Atrial Fibrillation , 2003, Pacing and clinical electrophysiology : PACE.

[29]  M. Berridge,et al.  Calcium signalling: dynamics, homeostasis and remodelling , 2003, Nature reviews. Molecular cell biology.

[30]  A. Brown,et al.  Role of the Cytosolic Chaperones Hsp70 and Hsp90 in Maturation of the Cardiac Potassium Channel hERG , 2003, Circulation research.

[31]  S. Priori,et al.  FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death , 2003, Cell.

[32]  Ferhaan Ahmad,et al.  Transgenic Mice Overexpressing Mutant PRKAG2 Define the Cause of Wolff-Parkinson-White Syndrome in Glycogen Storage Cardiomyopathy , 2003, Circulation.

[33]  L. Mounkes,et al.  A progeroid syndrome in mice is caused by defects in A-type lamins , 2003, Nature.

[34]  M. Josephson,et al.  Use of Electrogram Characteristics During Sinus Rhythm to Delineate the Endocardial Scar in a Porcine Model of Healed Myocardial Infarction , 2003, Journal of cardiovascular electrophysiology.

[35]  Calum A. MacRae,et al.  Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish , 2003, Circulation.

[36]  H. Duff,et al.  Selective Knockout of Mouse ERG1 B Potassium Channel Eliminates IKr in Adult Ventricular Myocytes and Elicits Episodes of Abrupt Sinus Bradycardia , 2003, Molecular and Cellular Biology.

[37]  Lucas J Herfst,et al.  Compound Heterozygosity for Mutations (W156X and R225W) in SCN5A Associated With Severe Cardiac Conduction Disturbances and Degenerative Changes in the Conduction System , 2003, Circulation research.

[38]  A. Gramolini,et al.  Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death , 2003, Nature.

[39]  S. Marx,et al.  Leucine/isoleucine zipper coordination of ion channel macromolecular signaling complexes in the heart. Roles in inherited arrhythmias. , 2003, Trends in cardiovascular medicine.

[40]  Knut Holthoff,et al.  Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2 , 2003, The EMBO journal.

[41]  Michel Haïssaguerre,et al.  Distinctive Electrophysiological Properties of Pulmonary Veins in Patients With Atrial Fibrillation , 2002, Circulation.

[42]  A. Wilde,et al.  Absence of Calsequestrin 2 Causes Severe Forms of Catecholaminergic Polymorphic Ventricular Tachycardia , 2002, Circulation research.

[43]  M. Cho,et al.  Cardiac remodeling and atrial fibrillation in transgenic miceoverexpressing junctin , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[44]  M. Allessie,et al.  Electrical, contractile and structural remodeling during atrial fibrillation. , 2002, Cardiovascular research.

[45]  Stanley Nattel,et al.  Cellular electrophysiology of atrial fibrillation. , 2002, Cardiovascular research.

[46]  J. Olgin,et al.  Transgenic and knockout mouse models of atrial arrhythmias. , 2002, Cardiovascular research.

[47]  M. Allessie,et al.  Analysis of altered gene expression during sustained atrial fibrillation in the goat. , 2002, Cardiovascular research.

[48]  Jamie I Vandenberg,et al.  Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[49]  J. Barhanin,et al.  The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[50]  J. Seidman,et al.  Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. , 2002, The Journal of clinical investigation.

[51]  S. Nattel New ideas about atrial fibrillation 50 years on , 2002, Nature.

[52]  S. Priori,et al.  Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia , 2002, Journal of cellular physiology.

[53]  M. Allessie,et al.  Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort. , 2002, Cardiovascular research.

[54]  M. Allessie,et al.  Time course of atrial fibrillation-induced cellular structural remodeling in atria of the goat. , 2001, Journal of molecular and cellular cardiology.

[55]  J. Seidman,et al.  Ventricular Arrhythmia Vulnerability in Cardiomyopathic Mice With Homozygous Mutant Myosin-Binding Protein C Gene , 2001, Circulation.

[56]  J. Nerbonne,et al.  Genetic Manipulation of Cardiac K+ Channel Function in Mice: What Have We Learned, and Where Do We Go From Here? , 2001, Circulation research.

[57]  D. Roden,et al.  Drug Block of I Kr : Model Systems and Relevance to Human Arrhythmias , 2001, Journal of cardiovascular pharmacology.

[58]  J. Fish,et al.  Electrical heterogeneity within the ventricular wall , 2001, Basic Research in Cardiology.

[59]  B. London,et al.  Cardiac Arrhythmias: From (Transgenic) Mice to Men , 2001, Journal of cardiovascular electrophysiology.

[60]  Willem Flameng,et al.  Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome , 2001, Nature Medicine.

[61]  W. Manning,et al.  Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein. , 2001, The Journal of clinical investigation.

[62]  D. Clapham,et al.  Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. , 2001, Journal of the American College of Cardiology.

[63]  T. Schwarz,et al.  The consequences of disrupting cardiac inwardly rectifying K+ current (IK1) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes , 2001, The Journal of physiology.

[64]  R. Elston,et al.  Sudden cardiac death, genes, and arrhythmogenesis: consideration of new population and mechanistic approaches from a National Heart, Lung, and Blood Institute workshop, Part II. , 2001, Circulation.

[65]  A. Moorman,et al.  Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part I: Phenotypic characterisation. , 2001, Cardiovascular research.

[66]  M. Rosen,et al.  Altering Ventricular Activation Remodels Gap Junction Distribution in Canine Heart , 2001, Journal of cardiovascular electrophysiology.

[67]  M. Franz,et al.  Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange– Nielsen Syndrome , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[68]  M. Sanguinetti,et al.  Molecular and Cellular Mechanisms of Cardiac Arrhythmias , 2001, Cell.

[69]  J. Seidman,et al.  The Genetic Basis for Cardiomyopathy from Mutation Identification to Mechanistic Paradigms , 2001, Cell.

[70]  Michael R. Rosen,et al.  Pathophysiology and Prevention of Atrial Fibrillation , 2001, Circulation.

[71]  S. Priori,et al.  Mutations in the Cardiac Ryanodine Receptor Gene (hRyR2) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia , 2001, Circulation.

[72]  R. Elston,et al.  Sudden cardiac death, genes, and arrhythmogenesis : consideration of new population and mechanistic approaches from a national heart, lung, and blood institute workshop, part I. , 2001, Circulation.

[73]  A. Feinberg,et al.  Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. , 2000, The Journal of clinical investigation.

[74]  P. J. Wang,et al.  Connexin40‐Deficient Mice Exhibit Atrioventricular Nodal and Infra‐Hisian Conduction Abnormalities , 2000, Journal of cardiovascular electrophysiology.

[75]  A. B. Brown,et al.  A Novel Genetic Pathway for Sudden Cardiac Death via Defects in the Transition between Ventricular and Conduction System Cell Lineages , 2000, Cell.

[76]  A. Camm,et al.  Congenital and acquired long QT syndrome. , 2000, European heart journal.

[77]  Mark T. Nelson,et al.  Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. , 2000, Circulation research.

[78]  P. Douglas,et al.  Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy , 2000, Nature Medicine.

[79]  J. Nerbonne,et al.  Rapid ventricular repolarization in rodents: electrocardiographic manifestations, molecular mechanisms, and clinical insights. , 2000, Journal of electrocardiology.

[80]  M. Allessie,et al.  Changes in ultrastructural calcium distribution in goat atria during atrial fibrillation. , 2000, Journal of molecular and cellular cardiology.

[81]  J Jalife,et al.  Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. , 2000, Circulation.

[82]  J. Seidman,et al.  Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. , 1999, The New England journal of medicine.

[83]  Moise Ns Inherited arrhythmias in the dog: potential experimental models of cardiac disease. , 1999 .

[84]  A. Wilde,et al.  Homozygous premature truncation of the HERG protein : the human HERG knockout. , 1999, Circulation.

[85]  A. Wilde,et al.  Cardiac conduction defects associate with mutations in SCN5A , 1999, Nature Genetics.

[86]  J. Dean,et al.  Cardiac involvement in Emery Dreifuss muscular dystrophy: a case series , 1999, Heart.

[87]  C. January,et al.  Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. , 1999, Circulation research.

[88]  S Nattel,et al.  Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. , 1999, Circulation research.

[89]  D. Housman,et al.  DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. , 1999, The Journal of clinical investigation.

[90]  C Antzelevitch,et al.  Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome. , 1999, Journal of electrocardiology.

[91]  N. S. Moïse Inherited arrhythmias in the dog: potential experimental models of cardiac disease. , 1999, Cardiovascular research.

[92]  M. Boutjdir,et al.  Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model. , 1998, Journal of immunology.

[93]  D. Escande,et al.  Adult KCNE1-knockout mice exhibit a mild cardiac cellular phenotype. , 1998, Biochemical and biophysical research communications.

[94]  T. Colatsky,et al.  Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice. , 1998, Circulation research.

[95]  J Clémenty,et al.  Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. , 1998, The New England journal of medicine.

[96]  J Jalife,et al.  Mechanisms of atrial fibrillation: mother rotors or multiple daughter wavelets, or both? , 1998, Journal of cardiovascular electrophysiology.

[97]  G. Breithardt,et al.  Experimental models of torsade de pointes. , 1998, Cardiovascular research.

[98]  N. Peters,et al.  Myocardial architecture and ventricular arrhythmogenesis. , 1998, Circulation.

[99]  L. Widman,et al.  Development and Validation of an ECG Algorithm for Identifying Accessory Pathway Ablation Site in Wolff‐Parkinson‐White Syndrome , 1998, Journal of cardiovascular electrophysiology.

[100]  N. Matsuoka,et al.  Characterization of stress-induced sudden death in cardiomyopathic hamsters. , 1998, The Journal of pharmacology and experimental therapeutics.

[101]  Y. Murakami,et al.  Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster: an animal model of disrupted dystrophin-associated glycoprotein complex. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[102]  S Nattel,et al.  Functional mechanisms underlying tachycardia-induced sustained atrial fibrillation in a chronic dog model. , 1997, Circulation.

[103]  N S Peters,et al.  Mechanisms causing sustained ventricular tachycardia with multiple QRS morphologies: results of mapping studies in the infarcted canine heart. , 1997, Circulation.

[104]  S Nattel,et al.  Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. , 1997, Circulation research.

[105]  M. Russo,et al.  Histological substrate of atrial biopsies in patients with lone atrial fibrillation. , 1997, Circulation.

[106]  M. Allessie,et al.  Verapamil reduces tachycardia-induced electrical remodeling of the atria. , 1997, Circulation.

[107]  J. Seidman,et al.  Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice. , 1997, The Journal of clinical investigation.

[108]  Frederick J. Schoen,et al.  A Mouse Model of Familial Hypertrophic Cardiomyopathy , 1996, Science.

[109]  M. Allessie,et al.  Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. , 1995, Circulation.

[110]  Douglas L. Jones,et al.  Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. , 1995, Circulation.

[111]  B. H. Branham,et al.  Anterior Septal Coronary Artery Infarction in the Canine: A Model of Ventricular Tachycardia With a Subendocardial Origin Ablation and Activation Sequence Mapping , 1994, Circulation.

[112]  J. Ruskin,et al.  Local activation variability during monomorphic ventricular tachycardia in the dog. , 1992, Cardiovascular research.

[113]  David E. Housman,et al.  Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member , 1992, Cell.

[114]  P B Corr,et al.  The surgical treatment of atrial fibrillation. III. Development of a definitive surgical procedure. , 1991, The Journal of thoracic and cardiovascular surgery.

[115]  J M de Bakker,et al.  Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation. , 1988, Circulation.

[116]  B F Hoffman,et al.  Atrial Reentry around an Anatomic Barrier with a Partially Refractory Excitable Gap: A Canine Model of Atrial Flutter , 1986, Circulation research.

[117]  J. Ruskin,et al.  Serial analysis of electrically induced ventricular arrhythmias in a canine model of myocardial infarction. , 1985, Journal of the American College of Cardiology.

[118]  N. Kouchoukos,et al.  Entrainment and Interruption of Atrial Flutter with Atrial Pacing: Studies in Man Following Open Heart Surgery , 1977, Circulation.

[119]  T. N. James,et al.  De subitaneis mortibus. XV. Hereditary stenosis of the His bundle in Pug dogs. , 1975, Circulation.

[120]  T. K. Marshall,et al.  De Subitaneis Mortibus: V. Occluded A‐V Node Artery , 1974, Circulation.

[121]  D. Garcia-Dorado,et al.  Cardiovascular Research , 1966 .