A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES

Previous studies have indicated that all naturally occurring murine leukemia viruses propagate significantly more efficiently on embryo cells of either NIH Swiss or BALB/c mice. Studies of the plaquing efficiency of representative viruses on embryo cells of various inbred and hybrid mice indicate that the pattern of sensitivity of the cells is genetically determined. All of 23 strains tested were found to resemble either NIH Swiss (N-type) or BALB/c (B-type) with respect to plaquing efficiency of these viruses. Virus growth on embryo cells derived from (N-type x B-type)F1 hybrids indicated dominance of resistance to both types of viruses. Backcross hybrid studies indicated that a single locus is the primary determinant of the host-range patterns observed. This locus has no effect on growth of certain laboratory-passaged leukemia viruses which propagate equally well on embryo cells of all mouse strains, F1, and backcross hybrids. Though other genetic and nongenetic factors influence viral growth or expression in vitro and in vivo, the genetic locus described appears of major significance in the biology of murine leukemia.

[1]  M. Festing,et al.  STANDARDIZED NOMENCLATURE FOR INBRED STRAINS OF RATS: Fourth Listing , 1973, Cancer research.

[2]  J. B. Humphrey,et al.  A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES , 1973, The Journal of experimental medicine.

[3]  J. Hartley,et al.  Plaque assay techniques for murine leukemia viruses. , 1970, Virology.

[4]  T. Pincus,et al.  Demonstration of Biological Activity of a Murine Leukemia Virus of New Zealand Black Mice , 1970, Science.

[5]  F. Lilly.  Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. , 1970, Journal of the National Cancer Institute.

[6]  R. Huebner,et al.  Host-Range Restrictions of Murine Leukemia Viruses in Mouse Embryo Cell Cultures , 1970, Journal of virology.

[7]  J. Hartley,et al.  Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture. , 1969, Proceedings of the National Academy of Sciences of the United States of America.

[8]  R. Huebner,et al.  FURTHER IMPLICATION OF MURINE LEUKEMIA-LIKE VIRUS IN THE DISORDERS OF NZB MICE , 1969, The Journal of experimental medicine.

[9]  R. Huebner,et al.  Isolation of Naturally Occurring Viruses of the Murine Leukemia Virus Group in Tissue Culture , 1969, Journal of virology.

[10]  T. Odaka,et al.  Inheritance of Susceptibility to Friend Mouse Leukemia Virus , 1968, Journal of virology.

[11]  L. Crittenden.  Observations on the nature of a genetic cellular resistance to avian tumor viruses. , 1968, Journal of the National Cancer Institute.

[12]  F. Lilly.  Susceptibility to Two Strains of Friend Leukemia Virus in Mice , 1967, Science.

[13]  R. Mellors,et al.  IMMUNOPATHOLOGY OF NZB/BL MICE , 1966, The Journal of experimental medicine.

[14]  A. Axelrad.  Genetic control of susceptibility to Friend leukemia virus in mice: studies with the spleen focus assay method. , 1966, National Cancer Institute monograph.

[15]  F. Lilly.  The inheritance of susceptibility to the Gross leukemia virus in mice. , 1966, Genetics.

[16]  P. Vogt,et al.  Reciprocal patterns of genetic resistance to avian tumor viruses in two lines of chickens. , 1965, Virology.

[17]  J. Tennant.  SUSCEPTIBILITY AND RESISTANCE TO VIRAL LEUKEMOGENESIS IN THE MOUSE. I. BIOLOGIC DEFINITION OF THE VIRUS. , 1965, Journal of the National Cancer Institute.

[18]  R. Huebner,et al.  Complement fixation and tissue culture assays for mouse leukemia viruses. , 1965, Proceedings of the National Academy of Sciences of the United States of America.

[19]  W. Okazaki,et al.  GENETIC RESISTANCE TO ROUS SARCOMA VIRUS IN EMBRYO CELL CULTURES AND EMBRYOS. , 1963, Virology.

[20]  I. Hilgert,et al.  Demonstration of the absence of infectious Rous virus in rat tumour XC, whose structurally intact cells produce Rous sarcoma when transferred to chicks. , 1963, Folia biologica.

[21]  T. Odaka,et al.  Inheritance of susceptibility to Friend mouse leukemia virus. , 1962, The Japanese journal of experimental medicine.

[22]  J. Tennant.  Derivation of a murine lymphoid leukemia virus. , 1962, Journal of the National Cancer Institute.

[23]  A. Fieldsteel,et al.  Quantitative Aspects of Friend Leukemia Virus in Various Murine Hosts ∗ † , 1961, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[24]  H. Kaplan,et al.  Leukemogenic Activity of Filtrates from Radiation-Induced Lymphoid Tumors of Mice , 1959, Science.

[25]  Charlotte Friend,et al.  CELL-FREE TRANSMISSION IN ADULT SWISS MICE OF A DISEASE HAVING THE CHARACTER OF A LEUKEMIA , 1957, The Journal of experimental medicine.

[26]  B. J. Helyer,et al.  The immunology and pathology of NZB mice. , 1968, Advances in immunology.

[27]  G. Snell.  The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism. , 1968, Folia biologica.

[28]  L. Gross.  Pathogenic potency and host range of the mouse leukemia virus. , 1963, Acta haematologica.

[29]  O. Frankfurt.  [The genetics of tissue transplantation]. , 1961, Patologicheskaia fiziologiia i eksperimental'naia terapiia.

[30]  L. Gross.  "Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos. , 1951, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.