Registration of Image Modalities for Analyses of Tissue Samples Using 3D Image Modelling

Biopsies are a diagnostic tool for the diagnosis of histopathological, molecular biological, proteomic, and imaging data, to narrow down disease patterns or identify diseases. Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) provides an emerging state‐of‐the‐art technique for molecular imaging of biological tissue. The aim of this study is the registration of MALDI MSI data sets and data acquired from different histological stainings to create a 3D model of biopsies and whole organs.

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