A functional polymorphism affecting the APOA5 gene expression is causally associated with plasma triglyceride levels conferring coronary atherosclerosis risk in Han Chinese Population.

[1]  E. Lefai,et al.  An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site. , 2014, American journal of human genetics.

[2]  Tanya M. Teslovich,et al.  Discovery and refinement of loci associated with lipid levels , 2013, Nature Genetics.

[3]  Tanya M. Teslovich,et al.  Common variants associated with plasma triglycerides and risk for coronary artery disease , 2013, Nature Genetics.

[4]  Päivi Pajukanta,et al.  Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci , 2013, Journal of Medical Genetics.

[5]  J. Danesh,et al.  Large-scale association analysis identifies new risk loci for coronary artery disease , 2012, Nature Genetics.

[6]  Wei Huang,et al.  Gene-Wide Characterization of Common Quantitative Trait Loci for ABCB1 mRNA Expression in Normal Liver Tissues in the Chinese Population , 2012, PloS one.

[7]  J. Aberle,et al.  Resequencing the apolipoprotein A5 (APOA5) gene in patients with various forms of hypertriglyceridemia. , 2011, Atherosclerosis.

[8]  S. Kathiresan,et al.  Genetic determinants of plasma triglycerides , 2011, Journal of Lipid Research.

[9]  Inês Barroso,et al.  Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[10]  Tanya M. Teslovich,et al.  Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.

[11]  Brian Tomlinson,et al.  Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese. , 2010, Atherosclerosis.

[12]  M. Seielstad,et al.  Genetic structure of the Han Chinese population revealed by genome-wide SNP variation. , 2009, American journal of human genetics.

[13]  Tom R. Gaunt,et al.  Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. , 2009, American journal of human genetics.

[14]  Benjamin M. Neale,et al.  Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae , 2009, PLoS genetics.

[15]  Michael Miller,et al.  The role of triglycerides in cardiovascular risk , 2008, Current cardiology reports.

[16]  P. Talmud,et al.  The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels. , 2008, Biochimica et biophysica acta.

[17]  Marcia M. Nizzari,et al.  Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels , 2007, Science.

[18]  J. Danesh,et al.  Triglycerides and the Risk of Coronary Heart Disease: 10 158 Incident Cases Among 262 525 Participants in 29 Western Prospective Studies , 2007, Circulation.

[19]  Le-ming Fan,et al.  A genetic variant c.553G > T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population. , 2006, Atherosclerosis.

[20]  M. Nagano,et al.  A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration Published, JLR Papers in Press, June 16, 2005. DOI 10.1194/jlr.D500018-JLR200 , 2005, Journal of Lipid Research.

[21]  L. Pennacchio,et al.  Apolipoprotein A-V Deficiency Results in Marked Hypertriglyceridemia Attributable to Decreased Lipolysis of Triglyceride-Rich Lipoproteins and Removal of Their Remnants , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[22]  P. Talmud,et al.  Determination of the Functionality of Common APOA5 Polymorphisms* , 2005, Journal of Biological Chemistry.

[23]  L. Pennacchio,et al.  Apolipoprotein AV Accelerates Plasma Hydrolysis of Triglyceriderich Lipoproteins by Interaction with Proteoglycan-bound Lipoprotein Lipase* , 2005, Journal of Biological Chemistry.

[24]  J. Ordovás,et al.  The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk , 2005, Current opinion in lipidology.

[25]  L. Pennacchio,et al.  Insulin-Mediated Down-Regulation of Apolipoprotein A5 Gene Expression through the Phosphatidylinositol 3-Kinase Pathway: Role of Upstream Stimulatory Factor , 2005, Molecular and Cellular Biology.

[26]  M. Daly,et al.  Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..

[27]  M. Woodward,et al.  Serum Triglycerides as a Risk Factor for Cardiovascular Diseases in the Asia-Pacific Region , 2004, Circulation.

[28]  Thomas J. Hudson,et al.  Cis-Acting Regulatory Variation in the Human Genome , 2004, Science.

[29]  K. V. van Dijk,et al.  ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis* , 2004, Journal of Biological Chemistry.

[30]  L. Pennacchio,et al.  Analysis of Apolipoprotein A5, C3, and Plasma Triglyceride Concentrations in Genetically Engineered Mice , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[31]  L. Havekes,et al.  The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism? , 2004, Current opinion in lipidology.

[32]  M. Olivier,et al.  Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11. , 2004, Genomics.

[33]  X. Adiconis,et al.  The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore Published, JLR Papers in Press, September 1, 2003. DOI 10.1194/jlr.M300251-JLR200 , 2003, Journal of Lipid Research.

[34]  J. W. Gallagher,et al.  Structure and Interfacial Properties of Human Apolipoprotein A-V* , 2003, Journal of Biological Chemistry.

[35]  K. Chien,et al.  A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia. , 2003, Human molecular genetics.

[36]  X. Prieur,et al.  The Human Apolipoprotein AV Gene Is Regulated by Peroxisome Proliferator-activated Receptor-α and Contains a Novel Farnesoid X-activated Receptor Response Element* , 2003, Journal of Biological Chemistry.

[37]  N. Wareham,et al.  Variants in the APOC3 promoter insulin responsive element modulate insulin secretion and lipids in middle-aged men. , 2003, Biochimica et biophysica acta.

[38]  Jonathan C. Cohen,et al.  Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. , 2002, Human molecular genetics.

[39]  M. Olivier,et al.  Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. , 2002, Human molecular genetics.

[40]  R. Chamuleau,et al.  Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. , 2002, Biochemical and biophysical research communications.

[41]  Jonathan C. Cohen,et al.  An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing , 2001, Science.

[42]  P. Cullen Evidence that triglycerides are an independent coronary heart disease risk factor. , 2000, The American journal of cardiology.

[43]  R. Davis,et al.  The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. , 1998, Molecular biology of the cell.

[44]  C. Bouchard,et al.  Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[45]  J. Hokanson,et al.  Plasma Triglyceride Level is a Risk Factor for Cardiovascular Disease Independent of High-Density Lipoprotein Cholesterol Level: A Metaanalysis of Population-Based Prospective Studies , 1996, Journal of cardiovascular risk.

[46]  G. Mcclearn,et al.  Genetic and environmental influences on serum lipid levels in twins. , 1993, The New England journal of medicine.

[47]  Fei Chai,et al.  The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research. , 2013, Clinical biochemistry.

[48]  R. Havel Triglyceride-rich lipoproteins and plasma lipid transport. , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[49]  R. Collins,et al.  Common variants at 30 loci contribute to polygenic dyslipidemia , 2009, Nature Genetics.