A functional polymorphism affecting the APOA5 gene expression is causally associated with plasma triglyceride levels conferring coronary atherosclerosis risk in Han Chinese Population.
暂无分享,去创建一个
Yi Wang | Ying Wang | Wei Huang | Jinxiu Shi | Lingzhi Yang | Hong Wu | Beilan Wang | Weihua Shou | Zhi‐min Wang | Fang Xie
[1] E. Lefai,et al. An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site. , 2014, American journal of human genetics.
[2] Tanya M. Teslovich,et al. Discovery and refinement of loci associated with lipid levels , 2013, Nature Genetics.
[3] Tanya M. Teslovich,et al. Common variants associated with plasma triglycerides and risk for coronary artery disease , 2013, Nature Genetics.
[4] Päivi Pajukanta,et al. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci , 2013, Journal of Medical Genetics.
[5] J. Danesh,et al. Large-scale association analysis identifies new risk loci for coronary artery disease , 2012, Nature Genetics.
[6] Wei Huang,et al. Gene-Wide Characterization of Common Quantitative Trait Loci for ABCB1 mRNA Expression in Normal Liver Tissues in the Chinese Population , 2012, PloS one.
[7] J. Aberle,et al. Resequencing the apolipoprotein A5 (APOA5) gene in patients with various forms of hypertriglyceridemia. , 2011, Atherosclerosis.
[8] S. Kathiresan,et al. Genetic determinants of plasma triglycerides , 2011, Journal of Lipid Research.
[9] Inês Barroso,et al. Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[10] Tanya M. Teslovich,et al. Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.
[11] Brian Tomlinson,et al. Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese. , 2010, Atherosclerosis.
[12] M. Seielstad,et al. Genetic structure of the Han Chinese population revealed by genome-wide SNP variation. , 2009, American journal of human genetics.
[13] Tom R. Gaunt,et al. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. , 2009, American journal of human genetics.
[14] Benjamin M. Neale,et al. Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae , 2009, PLoS genetics.
[15] Michael Miller,et al. The role of triglycerides in cardiovascular risk , 2008, Current cardiology reports.
[16] P. Talmud,et al. The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels. , 2008, Biochimica et biophysica acta.
[17] Marcia M. Nizzari,et al. Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels , 2007, Science.
[18] J. Danesh,et al. Triglycerides and the Risk of Coronary Heart Disease: 10 158 Incident Cases Among 262 525 Participants in 29 Western Prospective Studies , 2007, Circulation.
[19] Le-ming Fan,et al. A genetic variant c.553G > T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population. , 2006, Atherosclerosis.
[20] M. Nagano,et al. A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration Published, JLR Papers in Press, June 16, 2005. DOI 10.1194/jlr.D500018-JLR200 , 2005, Journal of Lipid Research.
[21] L. Pennacchio,et al. Apolipoprotein A-V Deficiency Results in Marked Hypertriglyceridemia Attributable to Decreased Lipolysis of Triglyceride-Rich Lipoproteins and Removal of Their Remnants , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[22] P. Talmud,et al. Determination of the Functionality of Common APOA5 Polymorphisms* , 2005, Journal of Biological Chemistry.
[23] L. Pennacchio,et al. Apolipoprotein AV Accelerates Plasma Hydrolysis of Triglyceriderich Lipoproteins by Interaction with Proteoglycan-bound Lipoprotein Lipase* , 2005, Journal of Biological Chemistry.
[24] J. Ordovás,et al. The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk , 2005, Current opinion in lipidology.
[25] L. Pennacchio,et al. Insulin-Mediated Down-Regulation of Apolipoprotein A5 Gene Expression through the Phosphatidylinositol 3-Kinase Pathway: Role of Upstream Stimulatory Factor , 2005, Molecular and Cellular Biology.
[26] M. Daly,et al. Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..
[27] M. Woodward,et al. Serum Triglycerides as a Risk Factor for Cardiovascular Diseases in the Asia-Pacific Region , 2004, Circulation.
[28] Thomas J. Hudson,et al. Cis-Acting Regulatory Variation in the Human Genome , 2004, Science.
[29] K. V. van Dijk,et al. ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis* , 2004, Journal of Biological Chemistry.
[30] L. Pennacchio,et al. Analysis of Apolipoprotein A5, C3, and Plasma Triglyceride Concentrations in Genetically Engineered Mice , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[31] L. Havekes,et al. The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism? , 2004, Current opinion in lipidology.
[32] M. Olivier,et al. Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11. , 2004, Genomics.
[33] X. Adiconis,et al. The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore Published, JLR Papers in Press, September 1, 2003. DOI 10.1194/jlr.M300251-JLR200 , 2003, Journal of Lipid Research.
[34] J. W. Gallagher,et al. Structure and Interfacial Properties of Human Apolipoprotein A-V* , 2003, Journal of Biological Chemistry.
[35] K. Chien,et al. A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia. , 2003, Human molecular genetics.
[36] X. Prieur,et al. The Human Apolipoprotein AV Gene Is Regulated by Peroxisome Proliferator-activated Receptor-α and Contains a Novel Farnesoid X-activated Receptor Response Element* , 2003, Journal of Biological Chemistry.
[37] N. Wareham,et al. Variants in the APOC3 promoter insulin responsive element modulate insulin secretion and lipids in middle-aged men. , 2003, Biochimica et biophysica acta.
[38] Jonathan C. Cohen,et al. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. , 2002, Human molecular genetics.
[39] M. Olivier,et al. Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. , 2002, Human molecular genetics.
[40] R. Chamuleau,et al. Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. , 2002, Biochemical and biophysical research communications.
[41] Jonathan C. Cohen,et al. An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing , 2001, Science.
[42] P. Cullen. Evidence that triglycerides are an independent coronary heart disease risk factor. , 2000, The American journal of cardiology.
[43] R. Davis,et al. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. , 1998, Molecular biology of the cell.
[44] C. Bouchard,et al. Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study. , 1997, Arteriosclerosis, thrombosis, and vascular biology.
[45] J. Hokanson,et al. Plasma Triglyceride Level is a Risk Factor for Cardiovascular Disease Independent of High-Density Lipoprotein Cholesterol Level: A Metaanalysis of Population-Based Prospective Studies , 1996, Journal of cardiovascular risk.
[46] G. Mcclearn,et al. Genetic and environmental influences on serum lipid levels in twins. , 1993, The New England journal of medicine.
[47] Fei Chai,et al. The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research. , 2013, Clinical biochemistry.
[48] R. Havel. Triglyceride-rich lipoproteins and plasma lipid transport. , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[49] R. Collins,et al. Common variants at 30 loci contribute to polygenic dyslipidemia , 2009, Nature Genetics.