NSAIDs inhibit bone healing through the downregulation of TGF-β3 expression during endochondral ossification.

[1]  T. Salo,et al.  The Role of MMP8 in Cancer: A Systematic Review , 2019, International journal of molecular sciences.

[2]  Sakae Tanaka,et al.  Effect of the small compound TD‐198946 on glycosaminoglycan synthesis and transforming growth factor β3‐associated chondrogenesis of human synovium‐derived stem cells in vitro , 2019, Journal of tissue engineering and regenerative medicine.

[3]  A. Tamas,et al.  Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Reduces Oxidative and Mechanical Stress-Evoked Matrix Degradation in Chondrifying Cell Cultures , 2019, International journal of molecular sciences.

[4]  J. Post,et al.  Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments , 2018, Scientific Reports.

[5]  G. Vunjak‐Novakovic,et al.  Testing the potency of anti‐TNF‐α and anti‐IL‐1β drugs using spheroid cultures of human osteoarthritic chondrocytes and donor‐matched chondrogenically differentiated mesenchymal stem cells , 2018, Biotechnology progress.

[6]  Hae-Ryong Song,et al.  In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin , 2018, Tissue Engineering and Regenerative Medicine.

[7]  Sigrid A. Langhans Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning , 2018, Front. Pharmacol..

[8]  F. Sefat,et al.  Effect of transforming growth factor-β3 on mono and multilayer chondrocytes. , 2016, Cytokine.

[9]  A. Blejec,et al.  Gene expression of cultured human chondrocytes as a model for assessing neutralization efficacy of soluble TNFα by TNFα antagonists. , 2015, Biologicals : journal of the International Association of Biological Standardization.

[10]  G. Stein,et al.  Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading , 2015, Journal of cellular physiology.

[11]  T. Brosh,et al.  Statins Enhance Rotator Cuff Healing by Stimulating the COX2/PGE2/EP4 Pathway , 2014, The American journal of sports medicine.

[12]  Timothy P. Kurmis,et al.  The effect of nonsteroidal anti-inflammatory drug administration on acute phase fracture-healing: a review. , 2012, The Journal of bone and joint surgery. American volume.

[13]  P. Giannoudis,et al.  Do Nonsteroidal Anti-Inflammatory Drugs Affect Bone Healing? A Critical Analysis , 2012, TheScientificWorldJournal.

[14]  P. Giannoudis,et al.  The effect of antibiotics on bone healing: current evidence , 2011, Expert opinion on drug safety.

[15]  Thomas A Einhorn,et al.  The biology of fracture healing. , 2011, Injury.

[16]  P. Giannoudis,et al.  Nonsteroidal anti-inflammatory drugs: prostaglandins, indications, and side effects , 2011 .

[17]  P. Giannoudis,et al.  NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man , 2010, Journal of cellular and molecular medicine.

[18]  Gwo‐Jaw Wang,et al.  Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. , 2009, Toxicology.

[19]  S. Abramson,et al.  Prostaglandin E2 Exerts Catabolic Effects in Osteoarthritis Cartilage: Evidence for Signaling via the EP4 Receptor1 , 2008, The Journal of Immunology.

[20]  P. Giannoudis,et al.  Pharmacological agents and impairment of fracture healing: what is the evidence? , 2008, Injury.

[21]  Gwo‐Jaw Wang,et al.  Effects of anti-inflammatory drugs on proliferation, cytotoxicity and osteogenesis in bone marrow mesenchymal stem cells. , 2007, Biochemical pharmacology.

[22]  A. M. Simon,et al.  Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. , 2007, The Journal of bone and joint surgery. American volume.

[23]  Meijing Wang,et al.  HIGH PASSAGE NUMBER OF STEM CELLS ADVERSELY AFFECTS STEM CELL ACTIVATION AND MYOCARDIAL PROTECTION , 2006, Shock.

[24]  E Jones,et al.  Growing bone and cartilage. The role of mesenchymal stem cells. , 2006, The Journal of bone and joint surgery. British volume.

[25]  P. Giannoudis,et al.  Biology of mesenchymal stem cells. , 2005, Injury.

[26]  J. Bijlsma,et al.  Selective COX-2 inhibition is favorable to human early and late-stage osteoarthritic cartilage: a human in vitro study. , 2005, Osteoarthritis and cartilage.

[27]  I. Martin,et al.  Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. , 2004, Rheumatology.

[28]  J. Bijlsma,et al.  Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage. , 2002, Rheumatology.

[29]  R Cancedda,et al.  Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. , 2000, Journal of cell science.

[30]  M. Ho,et al.  Effects of nonsteroidal anti-inflammatory drugs and prostaglandins on osteoblastic functions. , 1999, Biochemical pharmacology.

[31]  O. Ljunggren,et al.  Inflammatory cytokines regulate proliferation of cultured human osteoblasts. , 1997, Acta orthopaedica Scandinavica.

[32]  K Banovac,et al.  Effect of Nonsteroidal Antiinflammatory Drugs on Fracture Healing: A Laboratory Study in Rats , 1995, Journal of orthopaedic trauma.

[33]  M. Centrella,et al.  Differential actions of prostaglandins in separate cell populations from fetal rat bone. , 1994, Endocrinology.

[34]  R. Pelker,et al.  The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats , 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[35]  S. Muallem,et al.  Modulation of osteoblast function by prostaglandins. , 1989, The American journal of physiology.

[36]  Louis C. Gerstenfeld,et al.  Fracture healing: mechanisms and interventions , 2015, Nature Reviews Rheumatology.

[37]  M. Malaise,et al.  Effects of meloxicam compared to acetylsalicylic acid in human articular chondrocytes. , 1997, Pharmacology.

[38]  R. Pigott,et al.  ICAM-1 expression on chondrocytes in rheumatoid arthritis: induction by synovial cytokines , 1992, Mediators of inflammation.