All-Solid-State Ultrashort Pulse Generator by Capacitive Chopping Circuit

High-voltage ultrashort pulse (HVUSP) is attaching more attention to advanced biomedicine. In this article, a capacitive chopping circuit (CCC) topology with all-solid-state switches is proposed, which can generate adjustable HVUSP with high power efficiency. The dual capacitors of opposite polarity are connected in series with the load, thus cutting off the discharge loop of a single capacitor and chopping out a narrow pulse with adjustable width. The CCC can be stacked modularly for higher amplitude. The working principle is analyzed and the power efficiency under different working conditions is simulated, along with the existing modularized HVUSP generation topologies. Finally, an eight-staged all-solid-state prototype based on the proposed CCC topology is developed. The adjustability of pulse parameters and staged performance is tested. The pulsewidth can be compressed to less than 10 ns at 6.5 kV. Output parameters can satisfy HVUSP electroporation in the biological scene.

[1]  H. Kim,et al.  Compact Solid-State Marx Modulator With Fast Switching for Nanosecond Pulse , 2022, IEEE Transactions on Power Electronics.

[2]  E. Vorobiev,et al.  Processing of sugar beets assisted by pulsed electric fields , 2022, Research in Agricultural Engineering.

[3]  Zhengmin Li,et al.  High-Frequency Bipolar Solid-State LTD Based on a Self-Triggering H-Bridge , 2022, IEEE Transactions on Power Electronics.

[4]  W. Ding,et al.  Improved Auxiliary Triggering Topology for High-Power Nanosecond Pulse Generators Based on Avalanche Transistors , 2021, IEEE Transactions on Power Electronics.

[5]  Weihua Jiang,et al.  Solid-State Bipolar Linear Transformer Driver Using Inductive Energy Storage , 2021, IEEE Transactions on Plasma Science.

[6]  C. Yao,et al.  MHz Nanosecond Rectangular Pulse Generator With High Voltage Gain and Multimode , 2021, IEEE Transactions on Power Electronics.

[7]  C. Yao,et al.  Investigation and Evaluation of Solid-State Marx Pulse Generator Based on 3-D Busbar , 2021, IEEE Transactions on Plasma Science.

[8]  Seung-Ho Song,et al.  Current-Loop Gate-Driving Circuit for Solid-State Marx Modulator With Fast-Rising Nanosecond Pulses , 2021, IEEE Transactions on Power Electronics.

[9]  T. Huiskamp,et al.  Ultrafast Switching of SiC MOSFETs for High-Voltage Pulsed-Power Circuits , 2020, IEEE Transactions on Plasma Science.

[10]  Chenguo Yao,et al.  In Vitro Experimental and Numerical Studies on the Preferential Ablation of Chemo-Resistant Tumor Cells Induced by High-Voltage Nanosecond Pulsed Electric Fields , 2020, IEEE Transactions on Biomedical Engineering.

[11]  C. Yao,et al.  A Polarity-Adjustable Nanosecond Pulse Generator Suitable for High Impedance Load , 2020, IEEE Transactions on Plasma Science.

[12]  H. Ryoo,et al.  Pulsed Power Modulator With Active Pull-Down Using Diode Reverse Recovery Time , 2020, IEEE Transactions on Power Electronics.

[13]  M. Casciola,et al.  Nanosecond Pulsed Electric Fields Induce Endoplasmic Reticulum Stress Accompanied by Immunogenic Cell Death in Murine Models of Lymphoma and Colorectal Cancer , 2019, Cancers.

[14]  R. Nuccitelli Nano-Pulse Stimulation Therapy for the Treatment of Skin Lesions , 2019, Bioelectricity.

[15]  Xinxin Wang,et al.  Sterilizing Processes and Mechanisms for Treatment of Escherichia coli with Dielectric-Barrier Discharge Plasma , 2019, Applied and Environmental Microbiology.

[16]  J. Biela,et al.  Nanosecond switching of ohmic loads using SiC MOSFETs in ultra-low inductive PCB-packages , 2019, 2019 21st European Conference on Power Electronics and Applications (EPE '19 ECCE Europe).

[17]  Hyoung-Suk Kim,et al.  Solid-State Pulsed Power Modulator With Fast Rising/Falling Time and High Repetition Rate for Pockels Cell Drivers , 2019, IEEE Transactions on Industrial Electronics.

[18]  Hongmei Liu,et al.  Characterization of Conductivity Changes During High-Frequency Irreversible Electroporation for Treatment Planning , 2018, IEEE Transactions on Biomedical Engineering.

[19]  K. Schoenbach,et al.  From the basic science of biological effects of ultrashort electrical pulses to medical therapies , 2018, Bioelectromagnetics.

[20]  Chengxiang Li,et al.  A Modular Generator of Nanosecond Pulses With Adjustable Polarity and High Repetition Rate , 2018, IEEE Transactions on Power Electronics.

[21]  C. Yao,et al.  Solid-State Nanosecond-Pulse Plasma Jet Apparatus Based on Marx Structure With Crowbar Switches , 2016, IEEE Transactions on Plasma Science.

[22]  A. Tokuchi,et al.  Influence of forward pumping current on current interruption by semiconductor opening switch , 2015, IEEE Transactions on Dielectrics and Electrical Insulation.

[23]  N. Jiang,et al.  Frequency‐dependent interaction of ultrashort E‐fields with nociceptor membranes and proteins , 2011, Bioelectromagnetics.

[24]  A. Kuthi,et al.  A linear, single-stage, nanosecond pulse generator for delivering intense electric fields to biological loads , 2009, IEEE Transactions on Dielectrics and Electrical Insulation.

[25]  H. Bluhm Pulsed Power Systems: Principles and Applications , 2006 .

[26]  C. Yao,et al.  Magnetic Coupling Resonant-Based Air-Isolated Module for High Voltage Pulse Generators , 2023, IEEE Transactions on Industrial Electronics.

[27]  C. Yao,et al.  High Voltage Pulse Generator Based on a Novel Magnetic Isolated Drive Circuit , 2022, IEEE Transactions on Power Electronics.