Is there more to glaucoma treatment than lowering IOP?

[1]  T. Lüscher,et al.  Modulation of endothelin-1-induced contractions by magnesium/calcium in porcine ciliary arteries , 2009, Graefe's Archive for Clinical and Experimental Ophthalmology.

[2]  J. Flammer,et al.  What is the present pathogenetic concept of glaucomatous optic neuropathy? , 2007, Survey of ophthalmology.

[3]  J. Flammer,et al.  Relationship Between Retinal Glial Cell Activation in Glaucoma and Vascular Dysregulation , 2007, Journal of glaucoma.

[4]  Charles Ramassamy,et al.  Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. , 2006, European journal of pharmacology.

[5]  G. Tezel.  Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences , 2006, Progress in Retinal and Eye Research.

[6]  Bin Liu,et al.  Epidermal Growth Factor Receptor Activation: An Upstream Signal for Transition of Quiescent Astrocytes into Reactive Astrocytes after Neural Injury , 2006, The Journal of Neuroscience.

[7]  K. Abu-Amero,et al.  Mitochondrial abnormalities in patients with primary open-angle glaucoma. , 2006, Investigative ophthalmology & visual science.

[8]  Chang Yong Lee,et al.  Antioxidant activity and polyphenol and procyanidin contents of selected commercially available cocoa-containing and chocolate products in the United States. , 2006, Journal of agricultural and food chemistry.

[9]  H. Hara,et al.  Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve. , 2006, Current neurovascular research.

[10]  M. Sánchez-Hidalgo,et al.  Protective effects of melatonin in experimental free radical‐related ocular diseases , 2006, Journal of pineal research.

[11]  J. Flammer,et al.  The pathogenesis of optic disc splinter haemorrhages: a new hypothesis. , 2006, Acta ophthalmologica Scandinavica.

[12]  Robert N Weinreb,et al.  Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma. , 2006, Archives of ophthalmology.

[13]  S. Lipton,et al.  Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. , 2005, Investigative ophthalmology & visual science.

[14]  Anne Eckert,et al.  Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism by Ginkgo Biloba Extract EGb 761 , 2005, Annals of the New York Academy of Sciences.

[15]  A. Törrönen,et al.  Catechins and procyanidins in berries of vaccinium species and their antioxidant activity. , 2005, Journal of agricultural and food chemistry.

[16]  E. Şener,et al.  Ginkgo biloba extract ameliorates ischemia reperfusion-induced renal injury in rats. , 2005, Pharmacological research.

[17]  M. Hernandez,et al.  Long-term activation of c-Fos and c-Jun in optic nerve head astrocytes in experimental ocular hypertension in monkeys and after exposure to elevated pressure in vitro , 2005, Brain Research.

[18]  A. Neufeld,et al.  Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2. , 2005, Investigative ophthalmology & visual science.

[19]  A. Izzotti,et al.  Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma. , 2005, Archives of ophthalmology.

[20]  M. King,et al.  Endothelin‐1 modulates anterograde fast axonal transport in the central nervous system , 2005, Journal of neuroscience research.

[21]  H. Schild,et al.  Increased DNA breaks and up-regulation of both G1 and G2 checkpoint genes p21WAF1/CIP1 and 14-3-3 σ in circulating leukocytes of glaucoma patients and vasospastic individuals , 2005, Amino Acids.

[22]  W. Vilser,et al.  Dorzolamide Influences the Autoregulation of Major Retinal Vessels Caused by Artificial Intraocular Pressure Elevation in Patients with POAG: A Clinical Study , 2005, Current eye research.

[23]  Y. Kitazawa,et al.  The effect of Ca2+-antagonist on visual field in low-tension glaucoma , 1988, Graefe's Archive for Clinical and Experimental Ophthalmology.

[24]  J. Flammer,et al.  The relationship between digital and ocular vasospasm , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[25]  S. Orgül,et al.  Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma , 2004, British Journal of Ophthalmology.

[26]  L. Zangwill,et al.  Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measures. , 2004, Investigative ophthalmology & visual science.

[27]  R. Stout,et al.  Laser Doppler Flowmetry Study of Systemic Vasoconstriction after Topical 2.5% Phenylephrine Eye Drops , 2004 .

[28]  M. Engler.  Vascular relaxation to omega-3 fatty acids: Comparison to sodium nitroprusside, nitroglycerin, papaverine, and D600 , 1992, Cardiovascular Drugs and Therapy.

[29]  S. Orgül,et al.  Fludrocortisone in the treatment of systemic hypotension in primary open-angle glaucoma patients , 2004, International Ophthalmology.

[30]  J. Flammer,et al.  Short-term effect of dipyridamole on blood flow velocities in the extraocular vessels , 2004, International Ophthalmology.

[31]  K. Kashiwagi,et al.  Association between Nocturnal Blood Pressure Reduction and Progression of Visual Field Defect in Patients with Primary Open-Angle Glaucoma or Normal-Tension Glaucoma , 2004, Japanese Journal of Ophthalmology.

[32]  B. Liu,et al.  Glaucomatous Optic Neuropathy: When Glia Misbehave , 2003, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[33]  S. Leutner,et al.  Effects of EGb 761® Ginkgo biloba Extract on Mitochondrial Function and Oxidative Stress , 2003, Pharmacopsychiatry.

[34]  J. Flammer,et al.  Influence of red wine on visual function and endothelin‐1 plasma level in a patient with optic neuritis , 2003, Annals of neurology.

[35]  S. De Flora,et al.  Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. , 2003, The American journal of medicine.

[36]  J. Caprioli,et al.  Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. , 2003, Investigative ophthalmology & visual science.

[37]  Rachelle Doody,et al.  Memantine in moderate-to-severe Alzheimer's disease. , 2003, The New England journal of medicine.

[38]  F. Semeraro,et al.  Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. , 2003, Ophthalmology.

[39]  C. Gentile,et al.  The chemistry of melatonin's interaction with reactive species , 2003, Journal of pineal research.

[40]  M. Fini,et al.  Deficiency in Matrix Metalloproteinase Gelatinase B (MMP-9) Protects against Retinal Ganglion Cell Death after Optic Nerve Ligation* , 2002, The Journal of Biological Chemistry.

[41]  H. Chung,et al.  Selective peroxynitrite scavenging activity of 3‐methyl‐1,2‐cyclopentanedione from coffee extract , 2002, The Journal of pharmacy and pharmacology.

[42]  T. Yorio,et al.  Human optic nerve head astrocytes as a target for endothelin-1. , 2002, Investigative ophthalmology & visual science.

[43]  E. Stefánsson,et al.  The impact of ocular blood flow in glaucoma , 2002, Progress in Retinal and Eye Research.

[44]  C. S. Ricard,et al.  Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray , 2002, Glia.

[45]  A. Fukushima,et al.  Chronic docosahexaenoic acid intake enhances expression of the gene for uncoupling protein 3 and affects pleiotropic mRNA levels in skeletal muscle of aged C57BL/6NJcl mice. , 2001, The Journal of nutrition.

[46]  A. Collins,et al.  In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[47]  J. Flammer.  Die glaukomatöse Optikusneuropathie: Ein Reperfusionsschaden , 2001 .

[48]  C. S. Ricard,et al.  Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes , 2001, Glia.

[49]  P. Le Bars,et al.  Efficacy and safety of a Ginkgo biloba extract , 2000, Public Health Nutrition.

[50]  C. Kappagoda,et al.  Effects of cocoa extracts on endothelium-dependent relaxation. , 2000, The Journal of nutrition.

[51]  R. Ritch.  Neuroprotection: is it already applicable to glaucoma therapy? , 2000, Current opinion in ophthalmology.

[52]  R. Ritch.  Potential role for Ginkgo biloba extract in the treatment of glaucoma. , 2000, Medical hypotheses.

[53]  B Becker,et al.  Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[54]  J Flammer,et al.  Vascular dysregulation: a principal risk factor for glaucomatous damage? , 1999, Journal of glaucoma.

[55]  M. Lebwohl,et al.  Scavenging of hydrogen peroxide and inhibition of ultraviolet light-induced oxidative DNA damage by aqueous extracts from green and black teas. , 1999, Free radical biology & medicine.

[56]  T. Shimokawa,et al.  Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid. , 1999, Biochemical and biophysical research communications.

[57]  J. Biollaz,et al.  Circadian variations of renal sodium handling in patients with orthostatic hypotension. , 1998, Kidney international.

[58]  M. Wolzt,et al.  Reversal of endothelin‐1—induced ocular hemodynamic effects by low‐dose nifedipine in humans , 1998, Clinical pharmacology and therapeutics.

[59]  P. Russell,et al.  Human and monkey trabecular meshwork accumulate alpha B-crystallin in response to heat shock and oxidative stress. , 1996, Investigative ophthalmology & visual science.

[60]  T. Lüscher,et al.  Effect of dipyridamole on vascular responses of porcine ciliary arteries. , 1996, Current eye research.

[61]  J. Flammer,et al.  The influence of magnesium on visual field and peripheral vasospasm in glaucoma. , 1995, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[62]  G. Lang,et al.  The visual response to increased ocular blood flow in normal pressure glaucoma. , 1994, Survey of ophthalmology.

[63]  J. Flammer,et al.  Influence of Nifedipine on the Visual Fields of Patients with Optic-Nerve-Head Diseases , 1994, European journal of ophthalmology.

[64]  J. Flammer,et al.  Systemic hypotension: a risk factor for glaucomatous damage? , 1991, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[65]  J. Flammer,et al.  Short- and Long-Term Effect of Nifedipine on the Visual Field in Patients with Presumed Vasospasm , 1990, The Journal of international medical research.

[66]  A. Cerami,et al.  Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. , 1986, Science.

[67]  S. Drance,et al.  Effect of acetazolamide on the differential threshold. , 1983, Archives of ophthalmology.

[68]  S. Drance,et al.  Reversibility of a glaucomatous visual field defect after acetazolamide therapy. , 1983, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[69]  G. Paterson.  Effect of intravenous acetazolamide on relative arcuate scotomas and visual field in glaucoma simplex. , 1970, Proceedings of the Royal Society of Medicine.