Robotic implant to apply tissue traction forces in the treatment of esophageal atresia

This paper introduces robotic implants as a novel class of medical robots in the context of treating esophageal atresia. The robotic implant is designed to apply traction forces to the two disconnected esophageal segments to induce sufficient growth so that the two ends can be joined together to form a functioning esophagus. In contrast to the current manual method of externally applying traction forces, the implant offers the potential to avoid prolonged patient sedation and to substantially reduce the number of X-rays required. A prototype design is presented along with evaluation experiments that demonstrate its capabilities to apply traction forces to ex vivo esophageal tissues.

[1]  Maria Chiara Carrozza,et al.  A microrobot for colonoscopy , 1996, MHS'96 Proceedings of the Seventh International Symposium on Micro Machine and Human Science.

[2]  Shane M. Farritor,et al.  Mechanical Design of Robotic In Vivo Wheeled Mobility , 2007 .

[3]  Sanjay P Prabhu,et al.  A novel treatment for the midaortic syndrome. , 2012, The New England journal of medicine.

[4]  E. Fonkalsrud,et al.  Esophageal Replacement with Colon Interposition in Children , 1986, Annals of surgery.

[5]  M. Nagaya,et al.  Proposal of a novel method to evaluate anastomotic tension in esophageal atresia with a distal tracheoesophageal fistula , 2005, Pediatric Surgery International.

[6]  J. Foker,et al.  A flexible approach to achieve a true primary repair for all infants with esophageal atresia. , 2005, Seminars in pediatric surgery.

[7]  Marco A. Zenati,et al.  A Miniature Mobile Robot for Navigation and Positioning on the Beating Heart , 2009, IEEE Transactions on Robotics.

[8]  Marco A. Zenati,et al.  Integrated oral poster session 1: Wed 2/7 5:00 pmCardiothoracic III: Thoracic and cardiomyopathyP5: Subxiphoid epicardial pacing lead implantation using a miniature crawling robotic device , 2007 .

[9]  A. C. Simões e Silva,et al.  Current knowledge on esophageal atresia. , 2012, World journal of gastroenterology.

[10]  Paolo Dario,et al.  Design of a Pill-Sized 12-legged Endoscopic Capsule Robot , 2007, Proceedings 2007 IEEE International Conference on Robotics and Automation.

[11]  M. Martínez-Ferro,et al.  Extrathoracic esophageal elongation (Kimura's technique): a feasible option for the treatment of patients with complex esophageal atresia. , 2009, Journal of pediatric surgery.

[12]  S. Takamizawa,et al.  Multistaged esophageal elongation technique for long gap esophageal atresia: experience with 7 cases at a single institution. , 2005, Journal of pediatric surgery.

[13]  Federico Carpi,et al.  Magnetic Maneuvering of Endoscopic Capsules by Means of a Robotic Navigation System , 2009, IEEE Transactions on Biomedical Engineering.

[14]  David L. Trumper,et al.  A Hydraulically Controlled Nonoperative Magnetic Treatment for Long Gap Esophageal Atresia , 2011 .

[15]  J. Crandall,et al.  A Microcontinuum Model for Mechanical Properties of Esophageal Tissue: Experimental Methodology and Constitutive Analysis , 2013, Annals of Biomedical Engineering.

[16]  M.Q.-H. Meng,et al.  A Magnetic Stereo-Actuation Mechanism for Active Capsule Endoscope , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[17]  J. Foker,et al.  Development of a true primary repair for the full spectrum of esophageal atresia. , 1997, Annals of surgery.

[18]  Ioannis K. Kaliakatsos,et al.  Microrobots for minimally invasive medicine. , 2010, Annual review of biomedical engineering.

[19]  W H Hendren,et al.  Electromagnetic bougienage to lengthen esophageal segments in congenital esophageal atresia. , 1975, The New England journal of medicine.

[20]  K. Bax.  Jejunum for bridging long-gap esophageal atresia. , 2009, Seminars in Pediatric Surgery.

[21]  S. Stylianos,et al.  Multistaged extrathoracic esophageal elongation procedure for long gap esophageal atresia: Experience with 12 patients. , 2001, Journal of pediatric surgery.

[22]  Y. Fung.  Elasticity of soft tissues in simple elongation. , 1967, The American journal of physiology.

[23]  J. Foker,et al.  Long-gap esophageal atresia treated by growth induction: the biological potential and early follow-up results. , 2009, Seminars in pediatric surgery.