Spontaneous rupture of renal allografts: The importance of renal vein thrombosis in the cyclosporin era

Spontaneous renal allograft rupture occurring within 14 days of transplantation occurred in 15 patients from 791 consecutive transplants. In each of eight patients treated with azathioprine and prednisolone there was pathological evidence of rejection and only two patients had thrombosis of the renal vein. Of the seven cases occurring in patients treated with triple therapy regimen (low dose cyclosporin, prednisolone and azathioprine), histological evidence of rejection was present in only three cases, but renal vein thrombosis was found in all seven. Spontaneous rupture of a transplanted kidney, a relatively uncommon complication, is more likely to be due to renal vein thrombosis than to rejection in the cyclosporin era.

[1]  P. Morris,et al.  Antithymocyte globulin for steroid resistant rejection in renal transplant recipients immunosuppressed with triple therapy , 1989, Transplant international : official journal of the European Society for Organ Transplantation.

[2]  R. Allen,et al.  Triple therapy in cadaver renal transplantation , 1988, The British journal of surgery.

[3]  M. Dunnill,et al.  Renal vascular thrombosis of cadaveric renal allografts in patients receiving cyclosporin, azathioprine and prednisolone triple therapy , 1988 .

[4]  J. Thompson,et al.  CYCLOSPORIN CONVERSION VERSUS CONVENTIONAL IMMUNOSUPPRESSION: LONG-TERM FOLLOW-UP AND HISTOLOGICAL EVALUATION , 1987, The Lancet.

[5]  Z. Brown,et al.  Cyclosporine inhibits prostacyclin production by cultured human endothelial cells. , 1987, Transplantation proceedings.

[6]  S. Cameron,et al.  INCREASED FACTOR VIII AS AN INDEX OF VASCULAR INJURY IN CYCLOSPORINE NEPHROTOXICITY , 1986, Transplantation.

[7]  T. Lerut,et al.  THROMBOEMBOLIC COMPLICATIONS AND HAEMOSTATIC CHANGES IN CYCLOSPORIN-TREATED CADAVERIC KIDNEY ALLOGRAFT RECIPIENTS , 1985, The Lancet.

[8]  J. Salaman,et al.  FINE-NEEDLE INTRARENAL MANOMETRY: A NEW TEST FOR REJECTION IN CYCLOSPORIN-TREATED RECIPIENTS OF KIDNEY TRANSPLANTS , 1983, The Lancet.

[9]  L. Chan,et al.  LOW DOSE ORAL PREDNISOLONE IN RENAL TRANSPLANTATION , 1982, The Lancet.

[10]  R. Thukral,et al.  Renal allograft rupture: a report of three cases and review of the literature. , 1982, American journal of nephrology.

[11]  A. Mundy,et al.  The urological complications of 1000 renal transplants. , 1981, British journal of urology.

[12]  J. C. West,et al.  Should the ruptured renal allograft be removed? , 1979, Archives of surgery.

[13]  M. Bishop,et al.  RESULTS FROM A NEW RENAL TRANSPLANTATION UNIT , 1978, The Lancet.

[14]  O. Mellbye,et al.  Renal allograft rupture. , 1978, Scandinavian journal of urology and nephrology.

[15]  G. Kootstra,et al.  "Spontaneous" rupture of homografted kidneys. , 1974, Archives of surgery.

[16]  D. Effeney,et al.  Renal allograft rupture: cause, clinical features and management. , 1973, Annals of surgery.

[17]  J. H. Harrison,et al.  Five Years' Experience in Renal Transplantation with Immunosuppressive Drugs: Survival, Function, Complications, and the Role of Lymphocyte Depletion by Thoracic Duct Fistula , 1968, Annals of surgery.