Use and titration of positive end-expiratory pressure.

3. Scarpelli EM. The alveolar surface network: a new anatomy and its physiological significance. Anat Rec. 1998;251(4): 491–527. 4. Namati E, Thiesse J, de Ryk J, McLennan G. Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment? Am J Respir Cell Mol Biol. 2008;38(5):572–578. 5. Miedema M, deJongh FH, Frerichs I, van Veenendal MB, van Kaam AH. Regional respiratory time constants during lung recruitment in high‐frequency oscillatory ventilated preterm infants. Intensive Care Med. 2012;38(2):294–299. 6. Haas CF. Mechanical ventilation with lung protective strategies: what works? Crit Care Clin. 2011;27(3):469–486. 7. Marini JJ, Ravenscraft SA. Mean airway pressure: physiologic determinants and clinical importance—Part 2: clinical implications. Crit Care Med. 1992;20(11):1604–1616. 8. Donahoe M. Acute respiratory distress syndrome: a clinical review. Pulm Circ. 2011;1(2):192–211. 9. Ijland MM, Heunks LM, van der Hoeven JG. Bench‐to‐bedside review: hypercapnic acidosis in lung injury—from ‘permissive’ to ‘therapeutic’. Crit Care. 2010;14(6):237. 10. Chan KP, Stewart TE, Mehta S. High‐frequency oscillatory ventilation for adults with ARDS. Chest. 2007;131(6):1907–1916. 11. Takeuchi M, Sedeek KA, Schettino GPP, Suchodolski K, Kacmarek RM. Peak pressure during volume history and pressure–volume curve measurement affects analysis. Am J Respir Crit Care. 2001;164(7):1225–1230. 12. Lunangelo U, Bernabe F, Blanch L. Respiratory mechanics derived from signals in the ventilator circuit. Respir Care. 2005;50(1):55–65.

[1]  D. Chiumello.  Bedside ultrasound assessment of positive end expiratory pressure-induced lung recruitment. , 2012, American journal of respiratory and critical care medicine.

[2]  The Art Investigators.  Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial , 2012, Trials.

[3]  Arthur S Slutsky,et al.  Acute Respiratory Distress Syndrome The Berlin Definition , 2012 .

[4]  P. Spieth,et al.  Lung recruitment in ARDS: We are still confused, but on a higher PEEP level , 2012, Critical Care.

[5]  I. Frerichs,et al.  Regional respiratory time constants during lung recruitment in high-frequency oscillatory ventilated preterm infants , 2011, Pediatric Research.

[6]  C. Haas.  Mechanical ventilation with lung protective strategies: what works? , 2011, Critical care clinics.

[7]  M. Donahoe.  Acute respiratory distress syndrome: A clinical review , 2011, Pulmonary circulation.

[8]  J. G. van der Hoeven,et al.  Bench-to-bedside review: Hypercapnic acidosis in lung injury - from 'permissive' to 'therapeutic' , 2010, Critical care.

[9]  Matthias Briel,et al.  Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. , 2010, JAMA.

[10]  Marek Ancukiewicz,et al.  Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. , 2009, The New England journal of medicine.

[11]  Geoffrey McLennan,et al.  Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment? , 2008, American journal of respiratory cell and molecular biology.

[12]  Arthur S Slutsky,et al.  Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. , 2008, JAMA.

[13]  Marco Moschetta,et al.  ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. , 2007, American journal of respiratory and critical care medicine.

[14]  N. MacIntyre,et al.  Respiratory Controversies in the Critical Care Setting , 2007 .

[15]  R. Branson,et al.  Respiratory controversies in the critical care setting. Do the NIH ARDS Clinical Trials Network PEEP/FIO2 tables provide the best evidence-based guide to balancing PEEP and FIO2 settings in adults? , 2007, Respiratory care.

[16]  G. Hedenstierna,et al.  Monitoring dead space during recruitment and PEEP titration in an experimental model , 2006, Intensive Care Medicine.

[17]  R. Kacmarek,et al.  A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial* , 2006, Critical care medicine.

[18]  R. Kacmarek,et al.  Peak pressure during volume history and pressure-volume curve measurement affects analysis. , 2001, American journal of respiratory and critical care medicine.

[19]  S. Magder,et al.  The use of respiratory variations in right atrial pressure to predict the cardiac output response to PEEP. , 2001, Journal of critical care.

[20]  D. Schoenfeld,et al.  Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. , 2000, The New England journal of medicine.

[21]  Peter M. Suter,et al.  Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. , 1999, JAMA.

[22]  C. Carvalho,et al.  Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. , 1998, The New England journal of medicine.

[23]  J. Marini,et al.  Mean airway pressure: Physiologic determinants and clinical importance‐Part 2 Clinical implications , 1992, Critical care medicine.

[24]  B. Lachmann,et al.  Open up the lung and keep the lung open , 1992, Intensive Care Medicine.

[25]  R. Jackson,et al.  Pulmonary oxygen toxicity. , 1985, Chest.

[26]  J. Bourdarias,et al.  Influence of Positive End-Expiratory Pressure on Left Ventricular Performance , 1982 .

[27]  Peter M. Suter,et al.  Optimum End-Expiratory Airway Pressure in Patients with Acute Pulmonary Failure , 1975 .

[28]  J. Murray,et al.  Continuous positive-pressure ventilation: effects on systemic oxygen transport and tissue oxygenation. , 1972, Annals of internal medicine.

[29]  R. Balk.  Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial , 2009 .

[30]  Umberto Lucangelo,et al.  Respiratory mechanics derived from signals in the ventilator circuit. , 2005, Respiratory care.

[31]  P. Suter,et al.  Changes of right ventricular function with positive end-expiratory pressure (PEEP) in man , 2004, Intensive Care Medicine.

[32]  V. Arrington,et al.  High frequency oscillatory ventilation. , 1994, Virginia medical quarterly : VMQ.

[33]  R. Lodato.  Oxygen toxicity. , 1990, Critical care clinics.