ASSESSING WORKING MEMORY IN REAL-LIFE SITUATIONS WITH FUNCTIONAL NEAR-INFRARED SPECTROSCOPY

Working memory is one of the most important functions in our brain, which has been widely studied with unreal-life measured technologies. A functional near-infrared spectroscopy (fNIRS) instrument with a portable and low-cost design is developed, which is capable of providing hemodynamic measurement associated with brain function in real-life situations. Using this instrument, we performed working memory studies involved in Chinese words encoding, verbal, and spatial stem recognition, which are mainly studied with other technologies. Our results show that fNIRS can well assess working memory activities, in comparison with the reported results mainly using other methodologies. Furthermore, we find that hemodynamic change in the prefrontal cortex during all working memory tasks is highly associated with subjects' behavioral data. fNIRS is shown to be a promising alternative to the current methodologies for studying or assessing functional brain activities in natural condition.

[1]  M. Ferrari,et al.  Principles, techniques, and limitations of near infrared spectroscopy. , 2004, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[2]  Chun Li,et al.  Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts. , 2003, Cancer research.

[3]  J B Poline,et al.  Brain imaging of language plasticity in adopted adults: can a second language replace the first? , 2001, NeuroImage.

[4]  M. Herrmann,et al.  Activation of the Prefrontal Cortex in Working Memory and Interference Resolution Processes Assessed with Near-Infrared Spectroscopy , 2008, Neuropsychobiology.

[5]  A. Villringer,et al.  Non-invasive optical spectroscopy and imaging of human brain function , 1997, Trends in Neurosciences.

[6]  Edward E. Smith,et al.  Working Memory: A View from Neuroimaging , 1997, Cognitive Psychology.

[7]  F. Jöbsis Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. , 1977, Science.

[8]  J. Gore,et al.  Origins of Spatial Working Memory Deficits in Schizophrenia: An Event-Related fMRI and Near-Infrared Spectroscopy Study , 2008, PloS one.

[9]  Edward E. Smith,et al.  A Parametric Study of Prefrontal Cortex Involvement in Human Working Memory , 1996, NeuroImage.

[10]  B. Chance,et al.  Development of a portable tissue oximeter using near infra-red spectroscopy , 2006, Medical and Biological Engineering and Computing.

[11]  S. Bunce,et al.  Functional near-infrared neuroimaging , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[12]  A. Villringer,et al.  Beyond the Visible—Imaging the Human Brain with Light , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[13]  Yi Zheng,et al.  Design and evaluation of a portable continuous-wave NIR topography instrument , 2006, International Conference on Photonics and Imaging in Biology and Medicine.

[14]  Edward E. Smith,et al.  Spatial working memory in humans as revealed by PET , 1993, Nature.

[15]  Ann-Christine Ehlis,et al.  Optical topography during a Go–NoGo task assessed with multi-channel near-infrared spectroscopy , 2005, Behavioural Brain Research.

[16]  J. Jonides,et al.  Dissociating verbal and spatial working memory using PET. , 1996, Cerebral cortex.

[17]  J. Jonides,et al.  Storage and executive processes in the frontal lobes. , 1999, Science.

[18]  Yoko Hoshi,et al.  Functional near-infrared spectroscopy: current status and future prospects. , 2007, Journal of biomedical optics.

[19]  Y. Hoshi Functional near-infrared optical imaging: utility and limitations in human brain mapping. , 2003, Psychophysiology.

[20]  A. Owen The Functional Organization of Working Memory Processes Within Human Lateral Frontal Cortex: The Contribution of Functional Neuroimaging , 1997, The European journal of neuroscience.

[21]  Meltem Izzetoglu,et al.  Detecting deception in the brain: a functional near-infrared spectroscopy study of neural correlates of intentional deception , 2005, SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring.

[22]  Edward Awh,et al.  Spatial versus Object Working Memory: PET Investigations , 1995, Journal of Cognitive Neuroscience.