Carbon fragmentation measurements and validation of the Geant4 nuclear reaction models for hadrontherapy

Nuclear fragmentation measurements are necessary when using heavy-ion beams in hadrontherapy to predict the effects of the ion nuclear interactions within the human body. Moreover, they are also fundamental to validate and improve the Monte Carlo codes for their use in planning tumor treatments. Nowadays, a very limited set of carbon fragmentation cross sections are being measured, and in particular, to our knowledge, no double-differential fragmentation cross sections at intermediate energies are available in the literature. In this work, we have measured the double-differential cross sections and the angular distributions of the secondary fragments produced in the (12)C fragmentation at 62 A MeV on a thin carbon target. The experimental data have been used to benchmark the prediction capability of the Geant4 Monte Carlo code at intermediate energies, where it was never tested before. In particular, we have compared the experimental data with the predictions of two Geant4 nuclear reaction models: the Binary Light Ions Cascade and the Quantum Molecular Dynamic. From the comparison, it has been observed that the Binary Light Ions Cascade approximates the angular distributions of the fragment production cross sections better than the Quantum Molecular Dynamic model. However, the discrepancies observed between the experimental data and the Monte Carlo simulations lead to the conclusion that the prediction capability of both models needs to be improved at intermediate energies.

[1]  D. Cebra,et al.  Peripheral collisions of 40 MeV/u 14N with a 197Au target , 1989 .

[2]  L. Sihver,et al.  Present status and validation of HIBRAC , 2009 .

[3]  S. Incerti,et al.  Geant4 developments and applications , 2006, IEEE Transactions on Nuclear Science.

[4]  Dieter Schardt,et al.  Heavy-ion tumor therapy: Physical and radiobiological benefits , 2010 .

[5]  A. Brahme,et al.  Ion beam transport in tissue-like media using the Monte Carlo code SHIELD-HIT. , 2004, Physics in medicine and biology.

[6]  M. Krämer,et al.  Ion beam transport calculations and treatment plans in particle therapy , 2010 .

[7]  B. Heusch,et al.  Peripheral interactions for 44 MeV/u 49Ar on 27Al and natTi targets , 1986 .

[8]  C. Borcea,et al.  Production of nuclei in $^{32,34,36}$S-induced reactions in the energy range 6-75 MeV/A , 1997 .

[9]  A. Budzanowski,et al.  Fragmentation of sup 12 C projectiles interacting with sup 12 C, sup 27 Al, and sup 58 Ni nuclei at energy 28. 7 MeV/nucleon , 1991 .

[10]  Hiroshi Nakashima,et al.  PHITS: A particle and heavy ion transport code system , 2006 .

[11]  J. Aichelin,et al.  “Quantum” molecular dynamics—a dynamical microscopic n-body approach to investigate fragment formation and the nuclear equation of state in heavy ion collisions , 1991 .

[12]  N. M. Sobolevsky,et al.  shield — universal Monte Carlo hadron transport code: scope and applications , 1999 .

[13]  Harald Paganetti,et al.  Relative biological effectiveness (RBE) values for proton beam therapy. , 2002, International journal of radiation oncology, biology, physics.

[14]  G. Folger,et al.  The Binary Cascade , 2004 .

[15]  F. Cerutti,et al.  The FLUKA code: Description and benchmarking , 2007 .

[16]  Ugo Amaldi,et al.  Radiotherapy with beams of carbon ions , 2005 .

[17]  Heuer,et al.  Temperatures and excitation energies of hot nuclei in the reactions of 32S+Ag and 16O+Ag at 30 MeV/nucleon. , 1989, Physical review. C, Nuclear physics.

[18]  Y. Blumenfeld,et al.  Projectile like fragment production in 14N-induced reactions at projectile energies of 60 MeV A , 1990 .

[19]  A Mairani,et al.  Benchmarking nuclear models of FLUKA and GEANT4 for carbon ion therapy , 2010, Physics in medicine and biology.

[20]  A. Ferrari,et al.  FLUKA: A Multi-Particle Transport Code , 2005 .

[21]  C. Guet Some aspects of intermediate energy heavy ion reactions , 1983 .

[22]  Tsang,et al.  Fragment production in intermediate energy heavy ion reactions. , 1987, Physical review. C, Nuclear physics.

[23]  Takada,et al.  Analysis of the (N,xN') reactions by quantum molecular dynamics plus statistical decay model. , 1995, Physical review. C, Nuclear physics.

[24]  O. Tarasov Analysis of momentum distributions of projectile fragmentation products , 2004 .