Comprehension of grammatical and emotional prosody is impaired in Alzheimer's disease.

Previous research has demonstrated impairment in comprehension of emotional prosody in individuals diagnosed with Alzheimer's disease (AD). The present pilot study further explored the prosodic processing impairment in AD, aiming to extend our knowledge to encompass both grammatical and emotional prosody processing. As expected, impairments were seen in emotional prosody. AD individuals were also found to be impaired in detecting sentence modality, suggesting that impairments in affective prosody processing in AD may be ascribed to a more general prosodic processing impairment, specifically in comprehending prosodic information signaled across the sentence level. AD participants were at a very mild stage of the disease, suggesting that prosody impairments occur early in the disease course.

[1]  E. Koff,et al.  Perception of affect in patients with dementia of the Alzheimer type. , 1991, Archives of neurology.

[2]  I. Kiss,et al.  Age-Related Decline in Perception of Prosodic Affect , 2001 .

[3]  Marta Kutas,et al.  Electrophysiological analysis of context effects in Alzheimer's disease. , 2003, Neuropsychology.

[4]  J. Hodges,et al.  Is semantic memory consistently impaired early in the course of Alzheimer's disease? Neuroanatomical and diagnostic implications , 1995, Neuropsychologia.

[5]  Ellen Bialystok,et al.  Handbook of Neurolinguistics , 1998 .

[6]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[7]  M. Pell On the Receptive Prosodic Loss in Parkinson's Disease , 1996, Cortex.

[8]  S R Baum,et al.  The Ability of Right- and Left-Hemisphere-Damaged Individuals to Produce and Interpret Prosodic Cues Marking Phrasal Boundaries , 1997, Language and speech.

[9]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[10]  Dc Washington Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. , 1994 .

[11]  M. Pell,et al.  The Ability to Perceive and Comprehend Intonation in Linguistic and Affective Contexts by Brain-Damaged Adults , 1997, Brain and Language.

[12]  M. Lamar,et al.  Prosody impairment and associated affective and behavioral disturbances in Alzheimer's disease , 1996, Neurology.

[13]  A G Samuel,et al.  An empirical and meta-analytic evaluation of the phoneme identification task. , 1993, Journal of experimental psychology. Human perception and performance.

[14]  L. Brosgole,et al.  Visual and auditory affect recognition in senile and normal elderly persons. , 1988, The International journal of neuroscience.

[15]  L. Brosgole,et al.  Mood recognition across the ages. , 1995, The International journal of neuroscience.

[16]  P. Aisen,et al.  A Phase II study targeting amyloid-β with 3APS in mild-to-moderate Alzheimer disease , 2006, Neurology.

[17]  M. Pell,et al.  The neural bases of prosody: Insights from lesion studies and neuroimaging , 1999 .

[18]  L. Mansur,et al.  Language and Communication Disorders in Dementia of the Alzheimer Type , 1998 .

[19]  D. Orbelo,et al.  Impaired affective prosody in AD , 2001, Neurology.

[20]  J. M. Pérez Trullen,et al.  Comparative Study of Aprosody in Alzheimer's Disease and in Multi-lnfarct Dementia , 1996 .

[21]  J. Montepare,et al.  Emotion processing in the visual and auditory domains by patients with Alzheimer's disease , 1999, Journal of the International Neuropsychological Society.

[22]  K W Greve,et al.  Emotion processing in Alzheimer's disease , 1997, Journal of the International Neuropsychological Society.

[23]  J. L. Miller,et al.  Effects of speaking rate and lexical status on phonetic perception. , 1988, Journal of experimental psychology. Human perception and performance.

[24]  A. Kaszniak,et al.  Processing of emotional cues in patients with dementia of the Alzheimer's type. , 1989, The International journal of neuroscience.