A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure.

[1]  Shuqiang Li,et al.  CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq , 2016, Genome Biology.

[2]  Hsin C. Lin,et al.  Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells , 2016, Proceedings of the National Academy of Sciences.

[3]  Christoph Bock,et al.  Single‐cell transcriptomes reveal characteristic features of human pancreatic islet cell types , 2015, EMBO reports.

[4]  P. Reynolds,et al.  Insulin demand regulates β cell number via the unfolded protein response. , 2015, The Journal of clinical investigation.

[5]  Jeremy L. Barth,et al.  Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve , 2015, Scientific Reports.

[6]  Allon M. Klein,et al.  Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells , 2015, Cell.

[7]  C. Donaldson,et al.  Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion , 2015, Nature Medicine.

[8]  Dale L. Greiner,et al.  Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets , 2015, Diabetes.

[9]  X. Zhuang,et al.  Spatially resolved, highly multiplexed RNA profiling in single cells , 2015, Science.

[10]  E. Stanley,et al.  Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines , 2015, Stem cell reports.

[11]  Ash A. Alizadeh,et al.  Robust enumeration of cell subsets from tissue expression profiles , 2015, Nature Methods.

[12]  S. Linnarsson,et al.  Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq , 2015, Science.

[13]  Antti Honkela,et al.  Fast and accurate approximate inference of transcript expression from RNA-seq data , 2014, Bioinform..

[14]  Gopika G. Nair,et al.  Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro , 2015, The EMBO journal.

[15]  D. Gifford,et al.  Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells , 2014, Nature Biotechnology.

[16]  James D. Johnson,et al.  Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells , 2014, Nature Biotechnology.

[17]  D. Melton,et al.  Generation of Functional Human Pancreatic β Cells In Vitro , 2014, Cell.

[18]  L. Groop,et al.  Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism , 2014, Proceedings of the National Academy of Sciences.

[19]  C. Donaldson,et al.  The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression , 2014, BMC Genomics.

[20]  N. Neff,et al.  Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq , 2014, Nature.

[21]  Björn Usadel,et al.  Trimmomatic: a flexible trimmer for Illumina sequence data , 2014, Bioinform..

[22]  Timur Zhiyentayev,et al.  Single-cell in situ RNA profiling by sequential hybridization , 2014, Nature Methods.

[23]  N. Morgan,et al.  GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans , 2014, Diabetologia.

[24]  George M. Church,et al.  Highly Multiplexed Subcellular RNA Sequencing in Situ , 2014, Science.

[25]  S. Shen-Orr,et al.  Computational deconvolution: extracting cell type-specific information from heterogeneous samples. , 2013, Current opinion in immunology.

[26]  Halit Ongen,et al.  Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome , 2013, Genome research.

[27]  C. Levetan,et al.  Distinctions between the islets of mice and men: implications for new therapies for type 1 and 2 diabetes. , 2013, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[28]  Jonathan Schug,et al.  Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. , 2013, Cell stem cell.

[29]  W. Vale,et al.  Urocortin 3 Marks Mature Human Primary and Embryonic Stem Cell-Derived Pancreatic Alpha and Beta Cells , 2012, PloS one.

[30]  M. McCarthy,et al.  Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. , 2012, Cell metabolism.

[31]  T. Hashimshony,et al.  CEL-Seq: single-cell RNA-Seq by multiplexed linear amplification. , 2012, Cell reports.

[32]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[33]  P. Clemons,et al.  A Human Islet Cell Culture System for High-Throughput Screening , 2012, Journal of biomolecular screening.

[34]  Teresa L. Mastracci,et al.  The endocrine pancreas: insights into development, differentiation, and diabetes , 2012, Wiley interdisciplinary reviews. Developmental biology.

[35]  Sinisa Hrvatin,et al.  Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3 , 2012, Nature Biotechnology.

[36]  U. Suter,et al.  Molecular mechanisms regulating myelination in the peripheral nervous system , 2012, Trends in Neurosciences.

[37]  N. Holliday,et al.  Drug Discovery Opportunities and Challenges at G Protein Coupled Receptors for Long Chain Free Fatty Acids , 2011, Front. Endocrin..

[38]  J. Schug,et al.  Transcriptomes of the major human pancreatic cell types , 2011, Diabetologia.

[39]  Mark M. Davis,et al.  Cell type–specific gene expression differences in complex tissues , 2010, Nature Methods.

[40]  Mark D. Robinson,et al.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..

[41]  D. Clayton,et al.  The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes , 2009, Nature Genetics.

[42]  D. Meyer,et al.  Molecular regulation of pancreas development in zebrafish. , 2010, Methods in cell biology.

[43]  S. Leach,et al.  Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas , 2009, Proceedings of the National Academy of Sciences.

[44]  H. Ishiguro,et al.  CFTR Functions as a Bicarbonate Channel in Pancreatic Duct Cells , 2009, The Journal of general physiology.

[45]  M. Grompe,et al.  Generation and Regeneration of Cells of the Liver and Pancreas , 2008, Science.

[46]  Rhona Mirsky,et al.  Negative regulation of myelination: Relevance for development, injury, and demyelinating disease , 2008, Glia.

[47]  N. Chao.  Faculty Opinions recommendation of In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. , 2008 .

[48]  Douglas A. Melton,et al.  In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.

[49]  P. Herrera,et al.  Genes controlling pancreas ontogeny. , 2008, The International journal of developmental biology.

[50]  Geoffrey E. Hinton,et al.  Visualizing Data using t-SNE , 2008 .

[51]  Hui Li,et al.  Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. , 2007, The Journal of clinical investigation.

[52]  U. Boggi,et al.  The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients , 2007, Diabetologia.

[53]  Jeho Shin,et al.  Leptin‐deficient (ob/ob) mouse‐ a new animal model of peripheral neuropathy of Type 2 diabetes and obesity , 2007 .

[54]  D. Drucker.  The role of gut hormones in glucose homeostasis. , 2007, The Journal of clinical investigation.

[55]  L. C. Murtaugh,et al.  Pancreas and beta-cell development: from the actual to the possible , 2006, Development.

[56]  D. Whitcomb,et al.  Human Pancreatic Digestive Enzymes , 2007, Digestive Diseases and Sciences.

[57]  Fei Li,et al.  The Leptin-Deficient (ob/ob) Mouse , 2006, Diabetes.

[58]  Camillo Ricordi,et al.  The unique cytoarchitecture of human pancreatic islets has implications for islet cell function , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Hans A. Kestler,et al.  Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype , 2005, Journal of Molecular Medicine.

[60]  Alvin C. Powers,et al.  Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy , 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[61]  H. Ishiguro,et al.  Mechanisms of bicarbonate secretion in the pancreatic duct. , 2005, Annual review of physiology.

[62]  Jean YH Yang,et al.  Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.

[63]  Jae-Hyoung Cho,et al.  Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea , 2003 .

[64]  In Kyu Lee,et al.  Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. , 2003, The Journal of clinical endocrinology and metabolism.

[65]  J S Wilson,et al.  Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. , 1999, The American journal of pathology.

[66]  F. Hauser,et al.  The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia? , 1993, Trends in biochemical sciences.

[67]  D. W. Hayden,et al.  Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques. , 1988, The American journal of pathology.

[68]  D. Grube,et al.  The microanatomy of human islets of Langerhans, with special reference to somatostatin (D-) cells. , 1983, Archivum histologicum Japonicum = Nihon soshikigaku kiroku.

[69]  L. Orci,et al.  FUNCTIONAL SUBDIVISION OF ISLETS OF LANGERHANS AND POSSIBLE ROLE OF D CELLS , 1975, The Lancet.