OregonFluor enables quantitative intracellular paired agent imaging to assess drug target availability in live cells and tissues

[1]  M. Dada.  Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: Late-Breaking Abstracts , 2021, Molecular Imaging and Biology.

[2]  Antonio R. Montaño,et al.  TRIPODD: a Novel Fluorescence Imaging Platform for In Situ Quantification of Drug Distribution and Therapeutic Response , 2021, Molecular Imaging and Biology.

[3]  R. Campbell,et al.  Structure- and mechanism-guided design of single fluorescent protein-based biosensors , 2021, Nature Chemical Biology.

[4]  Oliver T. Bruns,et al.  Shortwave infrared polymethine fluorophores matched to excitation lasers enable noninvasive, multicolor in vivo imaging in real time , 2020, Nature Chemistry.

[5]  Connor W. Barth,et al.  Near-infrared nerve-binding fluorophores for buried nerve tissue imaging , 2020, Science Translational Medicine.

[6]  Y. Urano,et al.  A Fluorescent Probe for Rapid, High-Contrast Visualization of Folate-Receptor-Expressing Tumors in Vivo. , 2020, Angewandte Chemie.

[7]  B. Koch,et al.  A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy , 2019, Nature Chemistry.

[8]  B. G. Sibinga Mulder,et al.  A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery , 2019, Nature Communications.

[9]  Jongmin Park,et al.  Development of Theragnostic Tool Using NIR Fluorescence Probe Targeting Mitochondria in Glioma Cells. , 2019, Bioconjugate chemistry.

[10]  S. Pletnev,et al.  Smallest near-infrared fluorescent protein evolved from cyanobacteriochrome as versatile tag for spectral multiplexing , 2019, Nature Communications.

[11]  J. Rho,et al.  A New Infrared Probe Targeting Mitochondria via Regulation of Molecular Hydrophobicity. , 2019, Bioconjugate chemistry.

[12]  William H. Bisson,et al.  Gut microbiota and intestinal FXR mediate the clinical benefits of metformin , 2018, Nature Medicine.

[13]  Jongmin Park,et al.  Near-IR Fluorescent Tracer for Glucose-Uptake Monitoring in Live Cells. , 2018, Bioconjugate chemistry.

[14]  J. Bewersdorf,et al.  Biological Insight from Super-Resolution Microscopy: What We Can Learn from Localization-Based Images. , 2018, Annual review of biochemistry.

[15]  C. Dittrich,et al.  Monitoring of erlotinib in pancreatic cancer patients during long-time administration and comparison to a physiologically based pharmacokinetic model , 2018, Cancer Chemotherapy and Pharmacology.

[16]  M. Ueda,et al.  Intracellular Protein-Labeling Probes for Multicolor Single-Molecule Imaging of Immune Receptor-Adaptor Molecular Dynamics. , 2017, Journal of the American Chemical Society.

[17]  Scott C. Davis,et al.  Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery , 2017, Theranostics.

[18]  L. Lavis.  Teaching Old Dyes New Tricks: Biological Probes Built from Fluoresceins and Rhodamines. , 2017, Annual review of biochemistry.

[19]  Philipp J. Keller,et al.  A general method to fine-tune fluorophores for live-cell and in vivo imaging , 2017, Nature Methods.

[20]  Michael Z. Lin,et al.  The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins. , 2017, Trends in biochemical sciences.

[21]  Connor W. Barth,et al.  Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging , 2017, ACS omega.

[22]  Brian P. Mehl,et al.  Bright photoactivatable fluorophores for single-molecule imaging , 2016, Nature Methods.

[23]  Zeno Lavagnino,et al.  Quantitative Assessment of Fluorescent Proteins , 2016, Nature Methods.

[24]  M. Clausen,et al.  FDA-approved small-molecule kinase inhibitors. , 2015, Trends in pharmacological sciences.

[25]  Xiaolin Nan,et al.  Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway , 2015, Proceedings of the National Academy of Sciences.

[26]  R. Weissleder,et al.  Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression. , 2015, Bioconjugate chemistry.

[27]  J. J. Macklin,et al.  A general method to improve fluorophores for live-cell and single-molecule microscopy , 2014, Nature Methods.

[28]  Eric A. Owens,et al.  Structure-Inherent Targeting of NIR Fluorophores for Parathyroid and Thyroid Gland Imaging , 2014, Nature Medicine.

[29]  William H. Bisson,et al.  A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain , 2014, Biology.

[30]  S. Peters,et al.  Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: comparative pharmacokinetics and drug-drug interactions. , 2014, Cancer treatment reviews.

[31]  Tayyaba Hasan,et al.  Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging , 2014, Nature Medicine.

[32]  R. Weissleder,et al.  Red Si-rhodamine drug conjugates enable imaging in GFP cells. , 2014, Chemical communications.

[33]  S. Hell,et al.  Polar red-emitting rhodamine dyes with reactive groups: synthesis, photophysical properties, and two-color STED nanoscopy applications. , 2014, Chemistry.

[34]  Suliana Manley,et al.  A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. , 2013, Nature chemistry.

[35]  Hak Soo Choi,et al.  Targeted zwitterionic near-infrared fluorophores for improved optical imaging , 2013, Nature Biotechnology.

[36]  Erdmann Rapp,et al.  Red-emitting rhodamines with hydroxylated, sulfonated, and phosphorylated dye residues and their use in fluorescence nanoscopy. , 2012, Chemistry.

[37]  R. Altman,et al.  Pharmacogenomics Knowledge for Personalized Medicine , 2012, Clinical pharmacology and therapeutics.

[38]  S. Ramalingam,et al.  An open-label study to describe pharmacokinetic parameters of erlotinib in patients with advanced solid tumors with adequate and moderately impaired hepatic function , 2012, Cancer Chemotherapy and Pharmacology.

[39]  Mark Bates,et al.  Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging , 2011, Nature Methods.

[40]  Hak Soo Choi,et al.  Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. , 2011, Angewandte Chemie.

[41]  Tayyaba Hasan,et al.  Imaging targeted-agent binding in vivo with two probes. , 2010, Journal of biomedical optics.

[42]  Michael W. Davidson,et al.  The fluorescent protein palette: tools for cellular imaging. , 2009, Chemical Society reviews.

[43]  Mike Heilemann,et al.  Super-resolution imaging with small organic fluorophores. , 2009, Angewandte Chemie.

[44]  C. Afonso,et al.  Synthesis and applications of Rhodamine derivatives as fluorescent probes. , 2009, Chemical Society reviews.

[45]  Christopher H Contag,et al.  Quantifying cell-surface biomarker expression in thick tissues with ratiometric three-dimensional microscopy. , 2009, Biophysical journal.

[46]  Vasilis Ntziachristos,et al.  In vivo investigation of breast cancer progression by use of an internal control. , 2009, Neoplasia.

[47]  S. Hell,et al.  Fluorescence nanoscopy by ground-state depletion and single-molecule return , 2008, Nature Methods.

[48]  S. Hell,et al.  Photostable, amino reactive and water-soluble fluorescent labels based on sulfonated rhodamine with a rigidized xanthene fragment. , 2008, Chemistry.

[49]  J. Ellenberg,et al.  Fluorophores for live cell imaging of AGT fusion proteins across the visible spectrum. , 2006, BioTechniques.

[50]  Nathan C Shaner,et al.  Novel chromophores and buried charges control color in mFruits. , 2006, Biochemistry.

[51]  Robert M. Hoffman,et al.  The multiple uses of fluorescent proteins to visualize cancer in vivo , 2005, Nature Reviews Cancer.

[52]  H. Kitano,et al.  A comprehensive pathway map of epidermal growth factor receptor signaling , 2005, Molecular systems biology.

[53]  R. Tsien.  A non-disruptive technique for loading calcium buffers and indicators into cells , 1981, Nature.