INFLUENCE OF CALCITRIOL & CALCIUM GLUCONATE ON WOUND HEALING - AN EXPERIMENTAL STUDY

Summary Calcitriol, an active metabolite of vitamin D3 is known to influence calcium metabolism leading to hypercalcemia. It has been reported that calcitriol also possesses antiproliferative activity which may influence wound healing . Due to paucity of information about the action of calcitriol on wound healing , the present study was planned & calcium gluconate & calcitriol were investigated for their action in excision, resutured incision & dead space wounds in male Wistar rats. It was observed that calcitriol impeded healing significantly in all the three wound models as compared to olive oil controls whereas calcium gluconate enhanced healing in all the three wound models significantly as compared to normal saline controls.

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