Risk assessment of GM plants: avoiding gridlock?

Cultivation of genetically modified crops is presently based largely on four crops containing few transgenes and grown in four countries. This will soon change and pose new challenges for risk assessment. A more structured approach that is as generic as possible is advocated to study consequences of gene flow. Hazards should be precisely defined and prioritized, with emphasis on quantifying elements of exposure. This requires coordinated effort between large, multidisciplinary research teams.

[1]  J. Tomiuk,et al.  A- or C-chromosomes, does it matter for the transfer of transgenes from Brassica napus , 2000, Theoretical and Applied Genetics.

[2]  J. Pleasants,et al.  Temporal and spatial overlap between monarch larvae and corn pollen , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Philip J. Dale,et al.  Potential for the environmental impact of transgenic crops , 2002, Nature Biotechnology.

[4]  Claire Halpin,et al.  Improved Paper Pulp from Plants with Suppressed Cinnamoyl-CoA Reductase or Cinnamyl Alcohol Dehydrogenase , 2002, Transgenic Research.

[5]  B. Andersen,et al.  Spontaneous hybridization between oilseed rape (Brassica Napus) and Weedy B. Campestris (Brassicaceae): A risk of growing genetically modified oilseed rape , 1994 .

[6]  A. Trewavas,et al.  Is opposition to GM crops science or politics? , 2001, EMBO reports.

[7]  J. Nap,et al.  The impact on biosafety of the phosphinothricin-tolerance transgene in inter-specific B. rapa×B. napus hybrids and their successive backcrosses , 1997, Theoretical and Applied Genetics.

[8]  R. Shaw,et al.  Fitness of F1 hybrids between weedy Brassica rapa and oilseed rape (B. napus) , 1998, Heredity.

[9]  G. Poppy,et al.  Potential side effects of insect-resistant transgenic plants on arthropod natural enemies. , 1999, Trends in biotechnology.

[10]  Rikke Bagger Jørgensen,et al.  SPONTANEOUS HYBRIDIZATION BETWEEN OILSEED RAPE (BRASSICA NAPUS) AND WEEDY RELATIVES , 1996 .

[11]  R. Phipps,et al.  Environmental benefits of genetically modified crops: Global and European perspectives on their ability to reduce pesticide use , 2002 .

[12]  I. Davenport,et al.  A direct regional scale estimate of transgene movement from genetically modified oilseed rape to its wild progenitors , 2000, Molecular ecology.

[13]  J. Losey,et al.  Assessing the impact of Cry1Ab-expressing corn pollen on monarch butterfly larvae in field studies , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Losey,et al.  Transgenic pollen harms monarch larvae , 1999, Nature.

[15]  F. Gould,et al.  Impact of intraplot mixtures of toxic and nontoxic plants on population dynamics of diamondback moth (Lepidoptera: Plutellidae) and its natural enemies , 1997 .

[16]  C. N. Stewart,et al.  Bt-transgenic oilseed rape hybridization with its weedy relative, Brassica rapa. , 2002, Environmental biosafety research.

[17]  N. Chua,et al.  Chemical-inducible systems for regulated expression of plant genes. , 2000, Current opinion in biotechnology.

[18]  Richard L. Hellmich,et al.  Impact of Bt corn pollen on monarch butterfly populations: A risk assessment , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Garry D. Peterson,et al.  The risks and benefits of genetically modified crops: a multidisciplinary perspective. , 2000 .

[20]  M. J. Wilkinson,et al.  Risks from transgenic crops , 1996, Nature.

[21]  G. Poppy.  GM crops: environmental risks and non-target effects. , 2000, Trends in plant science.

[22]  R. Jørgensen,et al.  Fitness of backcross and F2 hybrids between weedy Brassica rapa and oilseed rape (B. napus) , 1998, Heredity.

[23]  M. T. Oldenhof,et al.  Analysis of microspore-specific promoters in transgenic tobacco , 1997, Plant Molecular Biology.

[24]  Hails,et al.  Genetically modified plants - the debate continues. , 2000, Trends in ecology & evolution.

[25]  A. Gatehouse,et al.  The case of the monarch butterfly: a verdict is returned. , 2002, Trends in genetics : TIG.

[26]  H. Rogers,et al.  REVIEW ARTICLE Transgenic plants and the environment , 1995 .

[27]  J. Dunwell.  Future prospects for transgenic crops , 2004, Phytochemistry Reviews.

[28]  C. Damgaard,et al.  Male fitness of oilseed rape (Brassica napus), weedy B. rapa and their F1 hybrids when pollinating B. rapa seeds , 2002, Heredity.

[29]  M. Wilkinson,et al.  Transgene risk is low , 1998, Nature.