Porcine dermis implants in soft-tissue reconstruction: current status

Soft-tissue reconstruction for a variety of surgical conditions, such as abdominal wall hernia or pelvic organ prolapse, remains a challenge. There are numerous meshes available that may be simply categorized as either synthetic or biologic. Within biologic meshes, porcine dermal meshes have come to dominate the market. This review examines the current evidence for their use and the limitations of knowledge. Although there is increasing evidence to support their safety, long-term follow-up studies that support their efficacy are lacking. Numerous clinical trials that remain ongoing may help elucidate their precise role in soft-tissue reconstruction.

[1]  O. Guerra,et al.  Non-crosslinked porcine-derived acellular dermal matrix for the management of complex ventral abdominal wall hernias: a report of 45 cases , 2013, Hernia.

[2]  R. Read Milestones in the history of hernia surgery: Prosthetic repair , 2004, Hernia.

[3]  C. Divino,et al.  Use of Mesh During Ventral Hernia Repair in Clean-Contaminated and Contaminated Cases: Outcomes of 33,832 Cases , 2012, Annals of surgery.

[4]  R. Reed,et al.  A Review of Available Prosthetics for Ventral Hernia Repair , 2011, Annals of surgery.

[5]  T. Koepsell,et al.  Have Outcomes of Incisional Hernia Repair Improved With Time?: A Population-Based Analysis , 2003, Annals of surgery.

[6]  B. Matthews,et al.  Remodeling characteristics and biomechanical properties of a crosslinked versus a non-crosslinked porcine dermis scaffolds in a porcine model of ventral hernia repair , 2015, Hernia.

[7]  S. Pathak,et al.  Synthetic or biological mesh use in laparoscopic ventral mesh rectopexy – a systematic review , 2013, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[8]  M. Rosen,et al.  A 5-Year Clinical Experience With Single-Staged Repairs of Infected and Contaminated Abdominal Wall Defects Utilizing Biologic Mesh , 2013, Annals of surgery.

[9]  M. Rosen,et al.  Incisional ventral hernias: review of the literature and recommendations regarding the grading and technique of repair. , 2010, Surgery.

[10]  M. Rosen,et al.  Biologic mesh use practice patterns in abdominal wall reconstruction: a lack of consensus among surgeons , 2013, Hernia.

[11]  R. Bleichrodt,et al.  Repair of Parastomal Hernias with Biologic Grafts: A Systematic Review , 2011, Journal of Gastrointestinal Surgery.

[12]  B. Pomahac,et al.  Abdominal wall reconstruction using a non-cross-linked porcine dermal scaffold: a follow-up study , 2013, Hernia.

[13]  J. Hunt,et al.  The innate oxygen dependant immune pathway as a sensitive parameter to predict the performance of biological graft materials. , 2012, Biomaterials.

[14]  N. Smart,et al.  Durability of Biologic Implants for Use in Hernia Repair , 2012, Surgical innovation.

[15]  J. Hunt,et al.  A scientific evidence for the efficacy of biologic implants for soft tissue reconstruction , 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[16]  I. Daniels,et al.  Biologic meshes in perineal reconstruction following extra‐levator abdominoperineal excision (elAPE) , 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[17]  J. Deprest,et al.  Hernia repair: the search for ideal meshes , 2009, Hernia.

[18]  I. Daniels,et al.  Parastomal hernia repair outcomes in relation to stoma site with diisocyanate cross-linked acellular porcine dermal collagen mesh , 2011, Hernia.

[19]  C. Seiler,et al.  Laparoscopic versus open surgical techniques for ventral or incisional hernia repair. , 2011, The Cochrane database of systematic reviews.

[20]  K. Itani,et al.  Prospective study of single-stage repair of contaminated hernias using a biologic porcine tissue matrix: the RICH Study. , 2012, Surgery.

[21]  A. Petter-Puchner,et al.  Biological implants in abdominal wall repair , 2013, The British journal of surgery.

[22]  Biologic mesh for ventral hernia repair: a cautionary tale. , 2013, Annals of surgery.

[23]  K. Inaba,et al.  Long-term outcome of acellular dermal matrix when used for large traumatic open abdomen. , 2008, The Journal of trauma.

[24]  A. Walter,et al.  Adverse Events Associated With Pelvic Organ Prolapse Surgeries That Use Implants , 2013, Obstetrics and gynecology.

[25]  Their Families,et al.  LONG-TERM OUTCOMES , 2013 .

[26]  J. Hunt,et al.  In vitro activation of human leukocytes in response to contact with synthetic hernia meshes. , 2012, Clinical biochemistry.

[27]  C. Vater,et al.  Native cross-links in collagen fibrils induce resistance to human synovial collagenase. , 1979, The Biochemical journal.

[28]  M. Nahabedian,et al.  Indications and Outcomes Following Complex Abdominal Reconstruction With Component Separation Combined With Porcine Acellular Dermal Matrix Reinforcement , 2012, Annals of plastic surgery.

[29]  N. Francis,et al.  Laparoscopic extralevator abdominoperineal excision of the rectum: short-term outcomes of a prospective case series , 2014, Techniques in Coloproctology.

[30]  N. Williams,et al.  Parastomal hernia prevention using a novel collagen implant: a randomised controlled phase 1 study , 2008, Hernia.

[31]  W. Hop,et al.  Laparoscopic vs. open incisional hernia repair: a randomized clinical trial. , 2013, JAMA surgery.

[32]  J. Hunt,et al.  The in vivo evaluation of tissue-based biomaterials in a rat full-thickness abdominal wall defect model. , 2014, Journal of biomedical materials research. Part B, Applied biomaterials.

[33]  A. Bailey,et al.  quantitative determination of collagen cross-links. , 2009, Methods in molecular biology.

[34]  B. Chaudhary,et al.  A systematic review on the use of prophylactic mesh during primary stoma formation to prevent parastomal hernia formation , 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[35]  J. Jeekel,et al.  Recommendations for reporting outcome results in abdominal wall repair , 2013, Hernia.

[36]  A. D'Hoore,et al.  Long‐term outcome of laparoscopic ventral rectopexy for total rectal prolapse , 2004, The British journal of surgery.

[37]  J. Rosenberg,et al.  Nationwide prospective study of outcomes after elective incisional hernia repair. , 2013, Journal of the American College of Surgeons.

[38]  A. H. Nguyen,et al.  Comparison of Permacol™ and Strattice™ for the repair of abdominal wall defects , 2011, Hernia.

[39]  I. Daniels,et al.  Supplemental cross-linking in tissue-based surgical implants for abdominal wall repair. , 2012, International journal of surgery.

[40]  Corey R Deeken,et al.  Effect of repetitive loading on the mechanical properties of biological scaffold materials. , 2012, Journal of the American College of Surgeons.

[41]  E. Steyerberg,et al.  Mesh repair for postoperative wound dehiscence in the presence of infection: is absorbable mesh safer than non-absorbable mesh? , 2007, Hernia.

[42]  Corman Ml Classic articles in colonic and rectal surgery. A method of performing abdominoperineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon: by W. Ernest Miles, 1869-1947. , 1980 .

[43]  K. Itani,et al.  Evaluation of surgical outcomes of retro-rectus versus intraperitoneal reinforcement with bio-prosthetic mesh in the repair of contaminated ventral hernias , 2013, Hernia.

[44]  Benjamin C. Paul,et al.  Soft Polypropylene Mesh, But Not Cadaveric Dermis, Significantly Improves Outcomes in Midline Hernia Repairs Using the Components Separation Technique , 2009, Plastic and Reconstructive Surgery.

[45]  A. Bailey,et al.  Quantitative determination of collagen crosslinks. , 2000, Methods in molecular biology.

[46]  J. Hunt,et al.  Evaluation of six synthetic surgical meshes implanted subcutaneously in a rat model , 2016, Journal of tissue engineering and regenerative medicine.

[47]  T. Häggmark,et al.  Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer , 2007, The British journal of surgery.

[48]  F. Pruvot,et al.  Outcome in porcine acellular dermal matrix reinforcement of infected abdominal wall defects: a prospective study , 2015, Hernia.

[49]  M. Abbas,et al.  Outcome of Abdominal Wall Hernia Repair with Permacol™ Biologic Mesh , 2013, The American surgeon.

[50]  M. Sarr,et al.  Long-term outcomes (>5-year follow-up) with porcine acellular dermal matrix (Permacol™) in incisional hernias at risk for infection , 2013, Hernia.

[51]  E. Verdaasdonk,et al.  Long-term Follow-up of a Randomized Controlled Trial of Suture Versus Mesh Repair of Incisional Hernia , 2004, Annals of surgery.

[52]  B. Matthews,et al.  Effect of enzymatic degradation on the mechanical properties of biological scaffold materials , 2012, Surgical Endoscopy.

[53]  R. Bleichrodt,et al.  Surgical Techniques for Parastomal Hernia Repair: A Systematic Review of the Literature , 2012, Annals of surgery.

[54]  N. Francis,et al.  Reconstruction of the perineum following extralevator abdominoperineal excision for carcinoma of the lower rectum: a systematic review , 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[55]  H. Harris,et al.  A critical review of biologic mesh use in ventral hernia repairs under contaminated conditions , 2013, Hernia.

[56]  I. Daniels,et al.  Biological meshes: a review of their use in abdominal wall hernia repairs. , 2012, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[57]  K. Moyer,et al.  Complex Abdominal Wall Reconstruction: An Outcomes Review , 2013, Annals of plastic surgery.

[58]  H. Goor,et al.  Criteria for definition of a complex abdominal wall hernia , 2014, Hernia.

[59]  A. Dixon,et al.  How to deal with complications after laparoscopic ventral mesh rectopexy: lessons learnt from a tertiary referral centre , 2013, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[60]  A. Bhangu,et al.  Systematic Review and Meta-analysis of the Incidence of Incisional Hernia at the Site of Stoma Closure , 2012, World Journal of Surgery.

[61]  S. DeMeester,et al.  Onlay ventral hernia repairs using porcine non-cross-linked dermal biologic mesh , 2013, Hernia.