TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

[1]  Y. Li,et al.  The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells , 2019, Immunity.

[2]  H. Glatt,et al.  Interleukin-22 protects intestinal stem cells against genotoxic stress , 2019, Nature.

[3]  M. Sitkovsky,et al.  T Cell Subsets and T Cell-Mediated Immunity , 2019, Nijkamp and Parnham's Principles of Immunopharmacology.

[4]  F. Cunha,et al.  TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism , 2018, Cell Death & Disease.

[5]  M. Mahmoudi,et al.  Analysis of Th22, Th17 and CD4+cells co-producing IL-17/IL-22 at different stages of human colon cancer. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[6]  P. Foster,et al.  Th22 Cells Form a Distinct Th Lineage from Th17 Cells In Vitro with Unique Transcriptional Properties and Tbet-Dependent Th1 Plasticity , 2017, The Journal of Immunology.

[7]  A. Rizzo,et al.  Smad7 Knockdown Restores Aryl Hydrocarbon Receptor-mediated Protective Signals in the Gut. , 2016, Journal of Crohn's & colitis.

[8]  B. Bernstein,et al.  Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation , 2015, Nature.

[9]  Yanfang Jiang,et al.  The frequency of Th17 and Th22 cells in patients with colorectal cancer at pre-operation and post-operation , 2015, Immunological investigations.

[10]  T. Macdonald,et al.  Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth , 2014, Oncogene.

[11]  Chao He,et al.  TGFBI protein high expression predicts poor prognosis in colorectal cancer patients. , 2015, International journal of clinical and experimental pathology.

[12]  M. Karin,et al.  Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. , 2014, Immunity.

[13]  Y. Li,et al.  IL-22 Fate Reporter Reveals Origin and Control of IL-22 Production in Homeostasis and Infection , 2014, The Journal of Immunology.

[14]  Y. Dou,et al.  IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. , 2014, Immunity.

[15]  F. Powrie,et al.  Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model , 2013, The Journal of experimental medicine.

[16]  W. Leonard,et al.  Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis , 2013, Proceedings of the National Academy of Sciences.

[17]  Yongzhong Liu,et al.  Elevated serum IL-22 levels correlate with chemoresistant condition of colorectal cancer. , 2013, Clinical immunology.

[18]  R. D. Hatton,et al.  Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. , 2012, Immunity.

[19]  C. Datz,et al.  Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth , 2012, Nature.

[20]  Francis J. Huber,et al.  IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine , 2012, Nature.

[21]  J. Massagué TGF‐β signaling in development and disease , 2012, FEBS letters.

[22]  R. Jenq,et al.  Interleukin-22 Drives Endogenous Thymic Regeneration in Mice , 2012, Science.

[23]  Liang Zhou,et al.  The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. , 2012, Immunity.

[24]  E. Hobeika,et al.  Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles , 2011, Science.

[25]  S. Rutz,et al.  Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells , 2011, Nature Immunology.

[26]  J. Bluestone,et al.  Control of TH17 cells occurs in the Small Intestine , 2011, Nature.

[27]  Y. Wan,et al.  Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology , 2011, The Journal of experimental medicine.

[28]  J. Galon,et al.  Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. , 2011, Cancer research.

[29]  M. Veldhoen,et al.  Fate mapping of interleukin 17-producing T cells in inflammatory responses , 2011, Nature Immunology.

[30]  Todd Davidson,et al.  Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling , 2010, Nature.

[31]  Cynthia L Sears,et al.  A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses , 2009, Nature Medicine.

[32]  M. Veldhoen,et al.  Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. , 2009, Immunity.

[33]  D. Jarrossay,et al.  Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells , 2009, Nature Immunology.

[34]  H. Spits,et al.  Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells , 2009, Nature Immunology.

[35]  M. Hohenegger,et al.  NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist , 2009, Proceedings of the National Academy of Sciences.

[36]  M. Veldhoen,et al.  Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells , 2009, The Journal of experimental medicine.

[37]  A. Murphy,et al.  Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. , 2008, Immunity.

[38]  R. Flavell,et al.  TGF-β: A Master of All T Cell Trades , 2008, Cell.

[39]  Y. Fujii‐Kuriyama,et al.  Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells , 2008, Proceedings of the National Academy of Sciences.

[40]  J. Buer,et al.  The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins , 2008, Nature.

[41]  S. Sa,et al.  Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens , 2008, Nature Medicine.

[42]  B. Becher,et al.  IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis1 , 2007, The Journal of Immunology.

[43]  J. Berzofsky Faculty Opinions recommendation of TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. , 2007 .

[44]  T. Mcclanahan,et al.  TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology , 2007, Nature Immunology.

[45]  R. Flavell,et al.  Autocrine/paracrine TGFβ1 is required for the development of epidermal Langerhans cells , 2007, The Journal of experimental medicine.

[46]  A. Murphy,et al.  Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. , 2007, Immunity.

[47]  F. Sallusto,et al.  Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells , 2007, Nature Immunology.

[48]  Yoji Shimizu,et al.  T‐cell receptor signaling to integrins , 2007, Immunological reviews.

[49]  E. Shevach,et al.  Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells , 2007, The Journal of Immunology.

[50]  P. Valdez,et al.  Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis , 2007, Nature.

[51]  F. Sutterwala,et al.  Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. , 2006, Immunity.

[52]  Qiang Tian,et al.  Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes , 2006, Cell Research.

[53]  L. Fouser,et al.  Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides , 2006, The Journal of experimental medicine.

[54]  S. Wiles,et al.  In Vivo Bioluminescence Imaging of the Murine Pathogen Citrobacter rodentium , 2006, Infection and Immunity.

[55]  R. J. Hocking,et al.  TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. , 2006, Immunity.

[56]  F. Macian,et al.  NFAT proteins: key regulators of T-cell development and function , 2005, Nature Reviews Immunology.

[57]  Y. Wan,et al.  Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[58]  M. Parnham,et al.  Principles of immunopharmacology , 2005 .

[59]  M. Neurath,et al.  Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells1 , 2004, The Journal of Immunology.

[60]  S. Clare,et al.  Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium , 2004, Cellular microbiology.

[61]  U. Lendahl,et al.  Notch signaling in development and disease. , 2004, Seminars in cancer biology.

[62]  D. Littman,et al.  Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt+ Cells , 2004, Science.

[63]  D. Littman,et al.  Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. , 2004, Science.

[64]  Oreste Acuto,et al.  CD28-mediated co-stimulation: a quantitative support for TCR signalling , 2003, Nature Reviews Immunology.

[65]  G. Mayr,et al.  Analysis of subcellular calcium signals in T-lymphocytes. , 2003, Cellular signalling.

[66]  P. Schirmacher,et al.  Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[67]  H. Moses,et al.  Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration* , 2000, The Journal of Biological Chemistry.

[68]  Zemin Zhang,et al.  Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R* , 2000, The Journal of Biological Chemistry.

[69]  A. Noble,et al.  The Balance of Protein Kinase C and Calcium Signaling Directs T Cell Subset Development1 , 2000, The Journal of Immunology.

[70]  A. Woodard,et al.  Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells , 1995, The Journal of experimental medicine.

[71]  K. Murphy,et al.  The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model , 1995, The Journal of experimental medicine.

[72]  F. Emmrich,et al.  Intracellular Ca2+ pools in Jurkat T-lymphocytes. , 1993, The Biochemical journal.