Baicalin induces Mrgprb2-dependent pseudo-allergy in mice.

[1]  M. Furuno,et al.  Novel MRGPRX2 antagonists inhibit IgE‐independent activation of human umbilical cord blood‐derived mast cells , 2019, Journal of leukocyte biology.

[2]  Ruiqin Hou,et al.  Shuang-Huang-Lian injection induces an immediate hypersensitivity reaction via C5a but not IgE , 2018, Scientific Reports.

[3]  Xinzhong Dong,et al.  Saikosaponin A inhibits compound 48/80‐induced pseudo‐allergy via the Mrgprx2 pathway in vitro and in vivo , 2018, Biochemical pharmacology.

[4]  Xinzhong Dong,et al.  MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions , 2017, Biochemical pharmacology.

[5]  S. Valitutti,et al.  IL‐33 fine tunes mast cell degranulation and chemokine production at the single‐cell level , 2017, The Journal of allergy and clinical immunology.

[6]  Langchong He,et al.  Sinomenine potentiates P815 cell degranulation via upregulation of Ca2+ mobilization through the Lyn/PLCγ/IP3R pathway , 2016, International journal of immunopathology and pharmacology.

[7]  R. Geha,et al.  IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. , 2016, The Journal of allergy and clinical immunology.

[8]  K. O'Byrne,et al.  Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo , 2016, BMC Cancer.

[9]  H. Subramanian,et al.  Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases. , 2016, The Journal of allergy and clinical immunology.

[10]  Chunfu Wu,et al.  Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression , 2016, Scientific Reports.

[11]  Ting Li,et al.  Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7-O-β-d-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[12]  Yonggang Cao,et al.  Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus , 2016, Brain Research.

[13]  Jun Yao,et al.  Protective Effect of Baicalin Against Experimental Colitis via Suppression of Oxidant Stress and Apoptosis , 2016, Pharmacognosy magazine.

[14]  W. Zang,et al.  Baicalin inhibits toll-like receptor 2/4 expression and downstream signaling in rat experimental periodontitis. , 2016, International immunopharmacology.

[15]  M. Murakami,et al.  NecroX‐5 suppresses IgE/Ag‐stimulated anaphylaxis and mast cell activation by regulating the SHP‐1‐Syk signaling module , 2016, Allergy.

[16]  Xinzhong Dong,et al.  Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions , 2014, Nature.

[17]  C. Pucillo,et al.  Mast cell activation: A complex interplay of positive and negative signaling pathways , 2014, European journal of immunology.

[18]  M. Premzl.  Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. , 2014, Gene.

[19]  P. Bryce,et al.  IgE-mediated mast cell responses are inhibited by thymol-mediated, activation-induced cell death in skin inflammation. , 2014, The Journal of allergy and clinical immunology.

[20]  Langchong He,et al.  New method of screening allergenic components from Shuanghuanglian injection: with RBL-2H3/CMC model online HPLC/MS system. , 2014, Journal of pharmaceutical and biomedical analysis.

[21]  H. Subramanian,et al.  β-Defensins Activate Human Mast Cells via Mas-Related Gene X2 , 2013, The Journal of Immunology.

[22]  Dai-Hung Ngo,et al.  Gallic acid-grafted chitooligosaccharides suppress antigen-induced allergic reactions in RBL-2H3 mast cells. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[23]  I. Kim,et al.  Regulation of Cytosolic Phospholipase A2 Phosphorylation by Proteolytic Cleavage of Annexin A1 in Activated Mast Cells , 2012, The Journal of Immunology.

[24]  J. Lambris,et al.  G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2. , 2011, European journal of pharmacology.

[25]  Shuai He,et al.  Modeling a murine model of immunoglobulin-E (IgE)- mediated qingkailing injection anaphylaxis , 2011 .

[26]  Qi Chang,et al.  An LC-MS/MS method for the simultaneous determination of chlorogenic acid, forsythiaside A and baicalin in rat plasma and its application to pharmacokinetic study of shuang-huang-lian in rats. , 2010, Journal of pharmaceutical and biomedical analysis.

[27]  H. Huo,et al.  Anti-nociceptive mechanism of baicalin involved in intervention of TRPV1 in DRG neurons in vitro. , 2010, Journal of ethnopharmacology.

[28]  A. Parekh.  Store-operated CRAC channels: function in health and disease , 2010, Nature Reviews Drug Discovery.

[29]  Xiu-feng Wang,et al.  The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells , 2009, Acta Pharmacologica Sinica.

[30]  M. Furuno,et al.  Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors. , 2006, Biochemical and biophysical research communications.

[31]  C. Chen,et al.  Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. , 2005, The American journal of pathology.

[32]  T. Matsui,et al.  FcεRI Signaling of Mast Cells Activates Intracellular Production of Hydrogen Peroxide: Role in the Regulation of Calcium Signals 1 , 2003, The Journal of Immunology.