Feasibility of 8‐OHdG formation and hOGG1 induction in PBMCs for assessing oxidative DNA damage in the lung of COPD patients

Oxidative stress has long been recognized to play a role in chronic obstructive pulmonary disease (COPD); however, approaches for assessing oxidative stress are lacking. The objective of this study was to address the feasibility of measuring 8‐oxo‐7, 8‐dihydro‐2′‐deoxyguanosine (8‐OHdG) formation and human 8‐oxoguanine DNA glycosylase (hOGG1) induction in peripheral blood mononuclear cell (PBMC) to assess oxidative deoxyribonucleic acid (DNA) damage in the lung of smoking COPD patients.

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