Design, synthesis, and SAR of substituted acrylamides as factor Xa inhibitors.

[1]  P. Lam,et al.  Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa. , 2001, Journal of medicinal chemistry.

[2]  C. Dominguez,et al.  Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors. , 2000, Journal of medicinal chemistry.

[3]  J. T. Metz,et al.  Non-amidine-containing 1,2-dibenzamidobenzene inhibitors of human factor Xa with potent anticoagulant and antithrombotic activity. , 2000, Journal of medicinal chemistry.

[4]  B. Zhu,et al.  Antithrombotic and hemostatic capacity of factor Xa versus thrombin inhibitors in models of venous and arteriovenous thrombosis. , 2000, European journal of pharmacology.

[5]  D L Cheney,et al.  Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. , 1999, Journal of medicinal chemistry.

[6]  M. Whitlow,et al.  Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa. , 1998, Journal of medicinal chemistry.

[7]  Robert Huber,et al.  X-ray Structure of Active Site-inhibited Clotting Factor Xa , 1996, The Journal of Biological Chemistry.

[8]  D. Wolf,et al.  A Comparative Study of Prothrombinase and Thrombin Inhibitors in a Novel Rabbit Model of Non-Occlusive Deep Vein Thrombosis , 1994, Thrombosis and Haemostasis.

[9]  B. Zhu,et al.  Chapter 9. Factor Xa inhibitors: Recent advances in anticoagulant agents , 2000 .

[10]  R. Scarborough Chapter 8. Anticoagulant Strategies Targeting Thrombin and Factor Xa , 1995 .

[11]  W. C. Still,et al.  Direct synthesis of Z-unsaturated esters. A useful modification of the horner-emmons olefination. , 1983 .