Multi-tasking on chromatin with the SAGA coactivator complexes.

[1]  David Horn,et al.  Histone deacetylases. , 2008, Advances in experimental medicine and biology.

[2]  E. Hurt,et al.  The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11. , 2006, Molecular biology of the cell.

[3]  A. Shukla,et al.  Functional Analysis of H2B-Lys-123 Ubiquitination in Regulation of H3-Lys-4 Methylation and Recruitment of RNA Polymerase II at the Coding Sequences of Several Active Genes in Vivo* , 2006, Journal of Biological Chemistry.

[4]  F. Hediger,et al.  Nuclear pore association confers optimal expression levels for an inducible yeast gene , 2006, Nature.

[5]  Jean-Christophe Olivo-Marin,et al.  SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope , 2006, Nature.

[6]  D. Stillman,et al.  SWI/SNF Binding to the HO Promoter Requires Histone Acetylation and Stimulates TATA-Binding Protein Recruitment , 2006, Molecular and Cellular Biology.

[7]  D. Reinberg,et al.  Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II , 2006, Cell.

[8]  A. Shukla,et al.  Ubp8p, a Histone Deubiquitinase Whose Association with SAGA Is Mediated by Sgf11p, Differentially Regulates Lysine 4 Methylation of Histone H3 In Vivo , 2006, Molecular and Cellular Biology.

[9]  B. Franklin Pugh,et al.  Genome-Wide Relationships between TAF1 and Histone Acetyltransferases in Saccharomyces cerevisiae , 2006, Molecular and Cellular Biology.

[10]  M. Pazin,et al.  Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions , 2006, Science.

[11]  Danny Reinberg,et al.  Human but Not Yeast CHD1 Binds Directly and Selectively to Histone H3 Methylated at Lysine 4 via Its Tandem Chromodomains* , 2005, Journal of Biological Chemistry.

[12]  S. Khorasanizadeh,et al.  Double chromodomains cooperate to recognize the methylated histone H3 tail , 2005, Nature.

[13]  Yang Liu,et al.  Histone H3 Ser10 Phosphorylation-Independent Function of Snf1 and Reg1 Proteins Rescues a gcn5− Mutant in HIS3 Expression , 2005, Molecular and Cellular Biology.

[14]  J. Workman,et al.  The Proteasome Regulatory Particle Alters the SAGA Coactivator to Enhance Its Interactions with Transcriptional Activators , 2005, Cell.

[15]  Cyrus Martin,et al.  The diverse functions of histone lysine methylation , 2005, Nature Reviews Molecular Cell Biology.

[16]  Chen Gao,et al.  TFIID and Spt-Ada-Gcn5-Acetyltransferase Functions Probed by Genome-wide Synthetic Genetic Array Analysis Using a Saccharomyces cerevisiae taf9-ts Allele , 2005, Genetics.

[17]  Steven Hahn,et al.  Targets of the Gal4 Transcription Activator in Functional Transcription Complexes , 2005, Molecular and Cellular Biology.

[18]  S. Henikoff,et al.  Assembly of variant histones into chromatin. , 2005, Annual review of cell and developmental biology.

[19]  Megan F. Cole,et al.  Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast , 2005, Cell.

[20]  D. Bentley,et al.  Altered nucleosome occupancy and histone H3K4 methylation in response to ‘transcriptional stress’ , 2005, The EMBO journal.

[21]  D. Gottschling,et al.  Ubp10/Dot4p Regulates the Persistence of Ubiquitinated Histone H2B: Distinct Roles in Telomeric Silencing and General Chromatin , 2005, Molecular and Cellular Biology.

[22]  C. V. van Oevelen,et al.  Differential Requirement of SAGA Subunits for Mot1p and Taf1p Recruitment in Gene Activation , 2005, Molecular and Cellular Biology.

[23]  B. Chait,et al.  Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J. Yates,et al.  Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[25]  P. Grant,et al.  Effector Proteins for Methylated Histones: An Expanding Family , 2005, Cell cycle.

[26]  A. Hinnebusch,et al.  Interdependent Recruitment of SAGA and Srb Mediator by Transcriptional Activator Gcn4p , 2005, Molecular and Cellular Biology.

[27]  S. Berger,et al.  Histone H3 phosphorylation can promote TBP recruitment through distinct promoter‐specific mechanisms , 2005, The EMBO journal.

[28]  N. Krogan,et al.  Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. , 2005, Molecular cell.

[29]  T. Hughes,et al.  H2B Ubiquitin Protease Ubp8 and Sgf11 Constitute a Discrete Functional Module within the Saccharomyces cerevisiae SAGA Complex , 2005, Molecular and Cellular Biology.

[30]  J. Workman,et al.  The Deubiquitylation Activity of Ubp8 Is Dependent upon Sgf11 and Its Association with the SAGA Complex , 2005, Molecular and Cellular Biology.

[31]  Eric S. Lander,et al.  Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse , 2005, Cell.

[32]  John R. Yates,et al.  Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation , 2005, Nature.

[33]  N. Krogan,et al.  Histone H2B Ubiquitylation Is Associated with Elongating RNA Polymerase II , 2005, Molecular and Cellular Biology.

[34]  B. Pugh,et al.  Changes in genomewide occupancy of core transcriptional regulators during heat stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[35]  A. Kristjuhan,et al.  Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo , 2004, The EMBO journal.

[36]  J. Vandenhaute,et al.  Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS , 2004, The EMBO journal.

[37]  Nicola J. Rinaldi,et al.  Global position and recruitment of HATs and HDACs in the yeast genome. , 2004, Molecular cell.

[38]  D. Stillman,et al.  Role for Nhp6, Gcn5, and the Swi/Snf Complex in Stimulating Formation of the TATA-Binding Protein-TFIIA-DNA Complex , 2004, Molecular and Cellular Biology.

[39]  Patrick Schultz,et al.  Molecular architecture of the S. cerevisiae SAGA complex. , 2004, Molecular cell.

[40]  Michael A. Freitas,et al.  Application of mass spectrometry to the identification and quantification of histone post‐translational modifications , 2004, Journal of cellular biochemistry.

[41]  Charles Kooperberg,et al.  The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. , 2004, Genes & development.

[42]  K. Natarajan,et al.  An Array of Coactivators Is Required for Optimal Recruitment of TATA Binding Protein and RNA Polymerase II by Promoter-Bound Gcn4p , 2004, Molecular and Cellular Biology.

[43]  Pamela A. Silver,et al.  Genome-Wide Localization of the Nuclear Transport Machinery Couples Transcriptional Status and Nuclear Organization , 2004, Cell.

[44]  Peter A. Jones,et al.  Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Elisabeth Scheer,et al.  Gene-specific modulation of TAF10 function by SET9-mediated methylation. , 2004, Molecular cell.

[46]  Victor G Corces,et al.  Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. , 2004, Trends in genetics : TIG.

[47]  B. Pugh,et al.  A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae. , 2004, Molecular cell.

[48]  E. Ezhkova,et al.  Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. , 2004, Molecular cell.

[49]  Rein Aasland,et al.  The many colours of chromodomains. , 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.

[50]  Michael R Green,et al.  In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. , 2004, Genes & development.

[51]  John R Yates,et al.  Deubiquitination of Histone H2B by a Yeast Acetyltransferase Complex Regulates Transcription* , 2004, Journal of Biological Chemistry.

[52]  Karl Henry,et al.  Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. , 2004, Genes & development.

[53]  Oreto Antúnez,et al.  Sus1, a Functional Component of the SAGA Histone Acetylase Complex and the Nuclear Pore-Associated mRNA Export Machinery , 2004, Cell.

[54]  P. Grant,et al.  Histone acetyltransferase proteins contribute to transcriptional processes at multiple levels. , 2004, Advances in protein chemistry.

[55]  N. Krogan,et al.  Histone H 2 B Ubiquitylation Is Associated with Elongating RNA Polymerase II , 2004 .

[56]  A. Hinnebusch,et al.  Recruitment of SWI/SNF by Gcn4p Does Not Require Snf2p or Gcn5p but Depends Strongly on SWI/SNF Integrity, SRB Mediator, and SAGA , 2003, Molecular and Cellular Biology.

[57]  Danny Reinberg,et al.  Histone lysine methylation: a signature for chromatin function. , 2003, Trends in genetics : TIG.

[58]  Ali Shilatifard,et al.  Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. , 2003, Genes & development.

[59]  Mark Gerber,et al.  Transcriptional Elongation by RNA Polymerase II and Histone Methylation* , 2003, Journal of Biological Chemistry.

[60]  Michael A. Freitas,et al.  Identification of novel histone post-translational modifications by peptide mass fingerprinting , 2003, Chromosoma.

[61]  Jacques Côté,et al.  The diverse functions of histone acetyltransferase complexes. , 2003, Trends in genetics : TIG.

[62]  H. Reinke,et al.  Multiple Mechanistically Distinct Functions of SAGA at the PHO5 Promoter , 2003, Molecular and Cellular Biology.

[63]  M. Ptashne,et al.  Independent recruitment in vivo by Gal4 of two complexes required for transcription. , 2003, Molecular cell.

[64]  Hien G. Tran,et al.  Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes , 2003, The EMBO journal.

[65]  E. Seto,et al.  Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. , 2003, Current opinion in genetics & development.

[66]  C. Allis,et al.  Histone and chromatin cross-talk. , 2003, Current opinion in cell biology.

[67]  K. Luger.  Structure and dynamic behavior of nucleosomes. , 2003, Current opinion in genetics & development.

[68]  D. Stillman,et al.  Regulation of TATA-Binding Protein Binding by the SAGA Complex and the Nhp6 High-Mobility Group Protein , 2003, Molecular and Cellular Biology.

[69]  M. Johnston,et al.  The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. , 2003, Molecular cell.

[70]  Kevin Struhl,et al.  Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. , 2003, Molecular cell.

[71]  M. Groudine,et al.  Controlling the double helix , 2003, Nature.

[72]  John R. Yates,et al.  The Novel SLIK Histone Acetyltransferase Complex Functions in the Yeast Retrograde Response Pathway , 2002, Molecular and Cellular Biology.

[73]  Michael R. Green,et al.  Differential Requirement of SAGA Components for Recruitment of TATA-Box-Binding Protein to Promoters In Vivo , 2002, Molecular and Cellular Biology.

[74]  J. Workman,et al.  Function and Selectivity of Bromodomains in Anchoring Chromatin-Modifying Complexes to Promoter Nucleosomes , 2002, Cell.

[75]  Dimitris Thanos,et al.  Deciphering the Transcriptional Histone Acetylation Code for a Human Gene , 2002, Cell.

[76]  B. Turner,et al.  Cellular Memory and the Histone Code , 2002, Cell.

[77]  D. Sterner,et al.  SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[78]  J. Davie,et al.  Site-specific Loss of Acetylation upon Phosphorylation of Histone H3* , 2002, The Journal of Biological Chemistry.

[79]  F. Winston,et al.  Analysis of Spt7 Function in the Saccharomyces cerevisiae SAGA Coactivator Complex , 2002, Molecular and Cellular Biology.

[80]  J. Workman,et al.  Gal80 Confers Specificity on HAT Complex Interactions with Activators* , 2002, The Journal of Biological Chemistry.

[81]  Dimitris Tzamarias,et al.  Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1. , 2002, Molecular cell.

[82]  G. Längst,et al.  The dMi‐2 chromodomains are DNA binding modules important for ATP‐dependent nucleosome mobilization , 2002, The EMBO journal.

[83]  J. Svejstrup.  Chromatin elongation factors. , 2002, Current opinion in genetics & development.

[84]  Nevan J. Krogan,et al.  COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression* , 2002, The Journal of Biological Chemistry.

[85]  J. Vandenhaute,et al.  The Rpb9 Subunit of RNA Polymerase II Binds Transcription Factor TFIIE and Interferes with the SAGA and Elongator Histone Acetyltransferases* , 2002, The Journal of Biological Chemistry.

[86]  P. Grant,et al.  Role of the Ada2 and Ada3 Transcriptional Coactivators in Histone Acetylation* , 2002, The Journal of Biological Chemistry.

[87]  G. Orphanides,et al.  A Unified Theory of Gene Expression , 2002, Cell.

[88]  Ming-Ming Zhou,et al.  Bromodomain: an acetyl‐lysine binding domain , 2002, FEBS letters.

[89]  P. Grant,et al.  Histone H3 specific acetyltransferases are essential for cell cycle progression. , 2001, Genes & development.

[90]  Karolin Luger,et al.  Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions , 2001, The EMBO journal.

[91]  S. Berger,et al.  Snf1--a Histone Kinase That Works in Concert with the Histone Acetyltransferase Gcn5 to Regulate Transcription , 2001, Science.

[92]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[93]  M. Green,et al.  SAGA is an essential in vivo target of the yeast acidic activator Gal4p. , 2001, Genes & development.

[94]  F. Winston,et al.  The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4. , 2001, Genes & development.

[95]  J. Workman,et al.  Recruitment of HAT Complexes by Direct Activator Interactions with the ATM-Related Tra1 Subunit , 2001, Science.

[96]  T. Kodadek,et al.  The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II. , 2001, Molecular cell.

[97]  J. Workman,et al.  Histone Acetyltransferase Complexes Stabilize SWI/SNF Binding to Promoter Nucleosomes , 2001, Cell.

[98]  C. Peterson,et al.  Chromatin remodeling enzymes: who's on first? , 2001, Current Biology.

[99]  D. Lohr,et al.  Yeast chromatin structure and regulation of GAL gene expression. , 2001, Progress in nucleic acid research and molecular biology.

[100]  H. Dyson,et al.  Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. , 2000, Journal of molecular biology.

[101]  P. Evans,et al.  The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p , 2000, The EMBO journal.

[102]  B M Turner,et al.  Histone acetylation and an epigenetic code. , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[103]  C. Peterson,et al.  Global Role for Chromatin Remodeling Enzymes in Mitotic Gene Expression , 2000, Cell.

[104]  Michael R. Green,et al.  Redundant roles for the TFIID and SAGA complexes in global transcription , 2000, Nature.

[105]  C. Allis,et al.  Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. , 2000, Molecular cell.

[106]  K. Wilkinson.  Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. , 2000, Seminars in cell & developmental biology.

[107]  G. Thireos,et al.  The Gcn5 bromodomain co-ordinates nucleosome remodelling , 2000, Nature.

[108]  R. Kaufman,et al.  The Transcriptional Co-activator ADA5 Is Required for HAC1 mRNA Processing in Vivo * , 2000, The Journal of Biological Chemistry.

[109]  D. Sterner,et al.  Inhibition of TATA-Binding Protein Function by SAGA Subunits Spt3 and Spt8 at Gcn4-Activated Promoters , 2000, Molecular and Cellular Biology.

[110]  C. Allis,et al.  The language of covalent histone modifications , 2000, Nature.

[111]  H. Zoghbi,et al.  Glutamine repeats and neurodegeneration. , 2000, Annual review of neuroscience.

[112]  A. Dudley,et al.  The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo. , 1999, Genes & development.

[113]  H. Orr,et al.  Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7. , 1999, Human molecular genetics.

[114]  Fred Winston,et al.  The bromodomain: a chromatin-targeting module? , 1999, Nature Structural Biology.

[115]  P. Sudarsanam,et al.  The nucleosome remodeling complex, Snf/Swi, is required for the maintenance of transcription in vivo and is partially redundant with the histone acetyltransferase, Gcn5 , 1999, The EMBO journal.

[116]  G. Crabtree,et al.  Continuous and widespread roles for the Swi–Snf complex in transcription , 1999, The EMBO journal.

[117]  S. Berger,et al.  Histone acetyltransferase complexes. , 1999, Seminars in cell & developmental biology.

[118]  P. Ornaghi,et al.  The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4. , 1999, Journal of molecular biology.

[119]  Jerry L. Workman,et al.  Expanded Lysine Acetylation Specificity of Gcn5 in Native Complexes* , 1999, The Journal of Biological Chemistry.

[120]  Fred Winston,et al.  Functional Organization of the Yeast SAGA Complex: Distinct Components Involved in Structural Integrity, Nucleosome Acetylation, and TATA-Binding Protein Interaction , 1999, Molecular and Cellular Biology.

[121]  P. Grant,et al.  Transcription: A lesson in sharing? , 1998, Nature.

[122]  J R Yates,et al.  The ATM-related cofactor Tra1 is a component of the purified SAGA complex. , 1998, Molecular cell.

[123]  Michael R. Green,et al.  Dissecting the Regulatory Circuitry of a Eukaryotic Genome , 1998, Cell.

[124]  C. Brandl,et al.  TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes. , 1998, Journal of molecular biology.

[125]  John R Yates,et al.  A Subset of TAFIIs Are Integral Components of the SAGA Complex Required for Nucleosome Acetylation and Transcriptional Stimulation , 1998, Cell.

[126]  B. Turner,et al.  Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase , 1998, The EMBO journal.

[127]  D. Sterner,et al.  The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes. , 1998, Trends in cell biology.

[128]  C. Allis,et al.  Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. , 1998, Genes & development.

[129]  S. Berger,et al.  Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex , 1998, Molecular and Cellular Biology.

[130]  P. Sudarsanam,et al.  The SAGA of Spt proteins and transcriptional analysis in yeast: past, present, and future. , 1998, Cold Spring Harbor symposia on quantitative biology.

[131]  J. Workman,et al.  Alteration of nucleosome structure as a mechanism of transcriptional regulation. , 1998, Annual review of biochemistry.

[132]  C. Peterson,et al.  Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression , 1997, Molecular and cellular biology.

[133]  F. Winston,et al.  Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes. , 1997, Genetics.

[134]  R Ohba,et al.  Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. , 1997, Genes & development.

[135]  A. Wolffe,et al.  Histone acetylation: chromatin in action. , 1997, Trends in biochemical sciences.

[136]  A. Ruiz-García,et al.  Gcn5p is involved in the acetylation of histone H3 in nucleosomes , 1997, FEBS letters.

[137]  S. Berger,et al.  Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo , 1997, The EMBO journal.

[138]  S. Berger,et al.  Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation , 1997, Molecular and cellular biology.

[139]  Andrew J. Bannister,et al.  The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity , 1996, Cell.

[140]  C. Allis,et al.  Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines , 1996, Nature.

[141]  D. Edmondson,et al.  Chromatin and transcription , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[142]  C. Allis,et al.  Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation , 1996, Cell.

[143]  J. Hansen,et al.  The nucleosomal array: structure/function relationships. , 1996, Critical reviews in eukaryotic gene expression.

[144]  S. Roth.  Chromatin-mediated transcription repression in yeast , 1995 .

[145]  S. Roth.  Chromatin-mediated transcriptional repression in yeast. , 1995, Current opinion in genetics & development.

[146]  Alan P. Wolffe,et al.  A positive role for histone acetylation in transcription factor access to nucleosomal DNA , 1993, Cell.

[147]  M. Smith.  Histone structure and function. , 1991, Current opinion in cell biology.

[148]  M. Grunstein.  Histone function in transcription. , 1990, Annual review of cell biology.

[149]  R. Kornberg.  Chromatin structure: a repeating unit of histones and DNA. , 1974, Science.

[150]  A. Mirsky,et al.  ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS. , 1964, Proceedings of the National Academy of Sciences of the United States of America.