Polymorphisms of DNA Repair and Xenobiotic Genes Predispose to CpG Island Methylation in Non‐Neoplastic Gastric Mucosa

Background:  Genetic factors, related to DNA repair or xenobiotic pathways might confer different degrees of susceptibility to gastric carcinogenesis. CpG island hyper methylation (CIHM) is a major event in gastric carcinogenesis. We evaluated the association between XRCC1, GSTP1, GSTT1 and GSTM1 polymorphisms with CIHM status in non‐neoplastic gastric mucosa.

[1]  Hong Wang,et al.  Glutathione S-Transferase M1 Null Genotype Associated with Gastric Cancer Among Asians , 2010, Digestive Diseases and Sciences.

[2]  Ping Yang,et al.  Glutathione S-Transferase T1 (GSTT1) Gene Polymorphism and Gastric Cancer Susceptibility: A Meta-Analysis of Epidemiologic Studies , 2010, Digestive Diseases and Sciences.

[3]  Y. Nakagawa,et al.  Increased Number of CpG Island Hypermethylation in Tumor Suppressor Genes of Non-Neoplastic Gastric Mucosa Correlates with Higher Risk of Gastric Cancer , 2010, Digestion.

[4]  Y. Nakagawa,et al.  MTHFR 677T Carrier Influences the Methylation Status of H. Pylori-Infected Gastric Mucosa in Older Subjects , 2009, Digestive Diseases and Sciences.

[5]  Y. Nakagawa,et al.  Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa. , 2009, International journal of molecular medicine.

[6]  T. Tahara,et al.  Chronic nonsteroidal anti‐inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa , 2009, Cancer Science.

[7]  Makoto Watanabe,et al.  Impact of catechol-O-methyltransferase (COMT) gene polymorphism on promoter methylation status in gastric mucosa. , 2009, Anticancer research.

[8]  Y. Nakagawa,et al.  Increased number of methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity of chronic gastritis , 2009, European journal of gastroenterology & hepatology.

[9]  F. Clavel-Chapelon,et al.  DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. , 2008, International journal of epidemiology.

[10]  H. Tajiri,et al.  CpG Island Hypermethylation of Tumor‐Suppressor Genes in H. pylori‐Infected Non‐Neoplastic Gastric Mucosa Is Linked with Gastric Cancer Risk , 2008, Helicobacter.

[11]  Makoto Watanabe,et al.  Risk Prediction of Gastric Cancer by Analysis of Aberrant DNA Methylation in Non-Neoplastic Gastric Epithelium , 2007, Digestion.

[12]  A. Kaneda,et al.  High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk , 2006, Clinical Cancer Research.

[13]  R. Hayes,et al.  Selected DNA repair polymorphisms and gastric cancer in Poland. , 2005, Carcinogenesis.

[14]  C. Abnet,et al.  Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer. , 2004, Cancer letters.

[15]  Jingweng Wang,et al.  GST genetic polymorphisms and lung adenocarcinoma susceptibility in a Chinese population. , 2003, Cancer letters.

[16]  M. Christmann,et al.  Mechanisms of human DNA repair: an update. , 2003, Toxicology.

[17]  Hyeon Joo Lee,et al.  Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. , 2003, The American journal of pathology.

[18]  Kazuto Ito,et al.  Association of genetic polymorphisms of glutathione-S-transferase genes (GSTM1, GSTT1 and GSTP1) with familial prostate cancer risk in a Japanese population. , 2003, Anticancer research.

[19]  D. Christiani,et al.  Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[20]  A. Rashid,et al.  Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer , 2003, Gut.

[21]  S. Lee,et al.  Genetic polymorphisms of XRCC1 and risk of gastric cancer. , 2002, Cancer letters.

[22]  Chien-Jen Chen,et al.  Genetic polymorphisms of XRCC1 and risk of the esophageal cancer , 2001, International journal of cancer.

[23]  E J Duell,et al.  Polymorphisms in the DNA repair gene XRCC1 and breast cancer. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[24]  Hongbing Shen,et al.  Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population , 2000, International journal of cancer.

[25]  B. Levin,et al.  Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt. , 2000, Cancer letters.

[26]  D. Butkiewicz,et al.  Identification of four single nucleotide polymorphisms in DNA repair genes: XPA and XPB (ERCC3) in Polish population , 2000, Human mutation.

[27]  H. Pahl,et al.  Helicobacter pylori Activates Mitogen-activated Protein Kinase Cascades and Induces Expression of the Proto-oncogenes c-fos and c-jun * , 2000, The Journal of Biological Chemistry.

[28]  T. Lindahl,et al.  Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair. , 2000, Mutation research.

[29]  M. Spitz,et al.  Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck. , 1999, Carcinogenesis.

[30]  Y. Oda,et al.  Genotypes of glutathione S-transferase M1 and N-acetyltransferase 2 in Japanese patients with gastric cancer , 1999, Gastric Cancer.

[31]  B. Pan,et al.  Solution structure of the single-strand break repair protein XRCC1 N-terminal domain , 1999, Nature Structural Biology.

[32]  S. Baylin,et al.  Aging and DNA methylation in colorectal mucosa and cancer. , 1998, Cancer research.

[33]  J. Buolamwini,et al.  Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants , 1997, The Journal of Biological Chemistry.

[34]  D. Forman,et al.  Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. , 1997, Carcinogenesis.

[35]  K. Caldecott,et al.  XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. , 1996, Nucleic acids research.

[36]  S. Z. Abdel‐Rahman,et al.  A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies. , 1996, Cancer letters.

[37]  H. Bolt,et al.  Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. , 1994, The Biochemical journal.

[38]  B. Ketterer.  Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. , 1988, Mutation research.

[39]  Issa Jp.  CpG-island methylation in aging and cancer. , 2000 .

[40]  J. Hayes,et al.  The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. , 1995, Critical reviews in biochemistry and molecular biology.

[41]  S. Baylin,et al.  Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon , 1994, Nature Genetics.