Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study.

[1]  A. Rosengren,et al.  Myeloperoxidase as a marker of increasing systemic inflammation in smokers without severe airway symptoms. , 2007, Respiratory medicine.

[2]  D. Steven,et al.  Coronary plaque injury triggers neutrophil activation in patients with coronary artery disease. , 2007, Free radical biology & medicine.

[3]  R. Peters,et al.  C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003. , 2006, Atherosclerosis.

[4]  Nancy R Cook,et al.  The Effect of Including C-Reactive Protein in Cardiovascular Risk Prediction Models for Women , 2006, Annals of Internal Medicine.

[5]  H. Klemm,et al.  Heparins Increase Endothelial Nitric Oxide Bioavailability by Liberating Vessel-Immobilized Myeloperoxidase , 2006, Circulation.

[6]  N. Brot,et al.  Myeloperoxidase Impairs ABCA1-dependent Cholesterol Efflux through Methionine Oxidation and Site-specific Tyrosine Chlorination of Apolipoprotein A-I* , 2006, Journal of Biological Chemistry.

[7]  Jonathan C. Cohen,et al.  Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. , 2006, The New England journal of medicine.

[8]  M. Krempf,et al.  Hepatic PCSK9 Expression Is Regulated by Nutritional Status via Insulin and Sterol Regulatory Element-binding Protein 1c* , 2006, Journal of Biological Chemistry.

[9]  C. Junien,et al.  Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia , 2005, Human mutation.

[10]  Stanley L Hazen,et al.  ATVB in Focus Redox Mechanisms in Blood Vessels , 2005 .

[11]  N. Seidah,et al.  Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M400396-JLR200 , 2005, Journal of Lipid Research.

[12]  R. Leboeuf,et al.  Expression of Human Myeloperoxidase by Macrophages Promotes Atherosclerosis in Mice , 2005, Circulation.

[13]  J. Kastelein,et al.  What promise does PCSK9 hold? , 2005, Journal of the American College of Cardiology.

[14]  A. Gotto,et al.  A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. , 2005, Journal of the American College of Cardiology.

[15]  J. Breslow,et al.  Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia , 2005, Current opinion in lipidology.

[16]  R. Peters,et al.  Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study. , 2004, The American journal of medicine.

[17]  Marlene Goormastic,et al.  Serum Myeloperoxidase Levels Independently Predict Endothelial Dysfunction in Humans , 2004, Circulation.

[18]  Michael Kinter,et al.  Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. , 2004, The Journal of clinical investigation.

[19]  P. Libby,et al.  Hypochlorous Acid, a Macrophage Product, Induces Endothelial Apoptosis and Tissue Factor Expression: Involvement of Myeloperoxidase-Mediated Oxidant in Plaque Erosion and Thrombogenesis , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[20]  TP Leren,et al.  Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia , 2004, Clinical genetics.

[21]  M. Pepe,et al.  Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. , 2004, American journal of epidemiology.

[22]  J. Breslow,et al.  Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mices⃞s⃞ The online version of this article (available at http://www.jlr.org) contains one supplemental table. Published, JLR Papers in Press, August 1, 2003. DOI 10.1194/jlr.M300203-JLR200 , 2003, Journal of Lipid Research.

[23]  E. Topol,et al.  Prognostic value of myeloperoxidase in patients with chest pain. , 2003, The New England journal of medicine.

[24]  Jay D. Horton,et al.  Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[25]  C. Heeschen,et al.  Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes , 2003, Circulation.

[26]  Jonathan C. Cohen,et al.  Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia* , 2003, Journal of Biological Chemistry.

[27]  J. Weissenbach,et al.  Mutations in PCSK9 cause autosomal dominant hypercholesterolemia , 2003, Nature Genetics.

[28]  Jonathan C. Cohen,et al.  Molecular mechanisms of autosomal recessive hypercholesterolemia , 2003, Current opinion in lipidology.

[29]  M. Pepe.  The Statistical Evaluation of Medical Tests for Classification and Prediction , 2003 .

[30]  Gary L Myers,et al.  Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. , 2003, Circulation.

[31]  F. Crea,et al.  Widespread coronary inflammation in unstable angina. , 2003, The New England journal of medicine.

[32]  P. Libby.  Inflammation in atherosclerosis , 2002, Nature.

[33]  Kazuo Haze,et al.  Neutrophil Infiltration of Culprit Lesions in Acute Coronary Syndromes , 2002, Circulation.

[34]  Chunxiang Zhang,et al.  Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase , 2002, Science.

[35]  Jonathan C. Cohen,et al.  Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis , 2002, The Lancet.

[36]  E J Topol,et al.  Association between myeloperoxidase levels and risk of coronary artery disease. , 2001, JAMA.

[37]  Joseph L. Goldstein,et al.  The Cholesterol Quartet , 2001, Science.

[38]  Jonathan C. Cohen,et al.  Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor Protein , 2001, Science.

[39]  O. Descamps.  Familial hypercholesterolaemia in a Belgian community. , 2000, Acta cardiologica.

[40]  S. Hazen,et al.  Nitric Oxide Is a Physiological Substrate for Mammalian Peroxidases* , 2000, The Journal of Biological Chemistry.

[41]  N. Grishin,et al.  Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. , 2000, Science.

[42]  S. Hazen,et al.  Nitric oxide is a substrate for mammalian peroxidases , 2000 .

[43]  N. Day,et al.  EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. , 1999, British journal of cancer.

[44]  S. Hazen,et al.  Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro. , 1999, The Journal of clinical investigation.

[45]  D. Levy,et al.  Prediction of coronary heart disease using risk factor categories. , 1998, Circulation.

[46]  A. Daugherty,et al.  Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. , 1994, The Journal of clinical investigation.

[47]  R. Tibshirani,et al.  An Introduction to the Bootstrap , 1995 .

[48]  V. Babaev,et al.  Monocyte/macrophage accumulation and smooth muscle cell phenotypes in early atherosclerotic lesions of human aorta. , 1993, Atherosclerosis.

[49]  J. Davignon,et al.  Tendon xanthomas associated with cholestanolosis and hyperapobetalipoproteinemia. , 1986, Clinical and investigative medicine. Medecine clinique et experimentale.

[50]  P Ducimetière,et al.  Comparison of receiver operating curves derived from the same population: a bootstrapping approach. , 1985, Computers and biomedical research, an international journal.

[51]  H. Rosen,et al.  [52] Antimicrobial activity of myeloperoxidase , 1984 .

[52]  H. Rosen,et al.  Antimicrobial activity of myeloperoxidase. , 1984, Methods in enzymology.

[53]  S. Grundy,et al.  Metabolic studies in familial hypercholesterolemia. Evidence for a gene-dosage effect in vivo. , 1979, The Journal of clinical investigation.

[54]  W. Connor,et al.  Beta-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters. , 1974, The Journal of clinical investigation.