Combined cytotoxicity of polystyrene nanoplastics and phthalate esters on human lung epithelial A549 cells and its mechanism.

[1]  T. Rocha-Santos,et al.  Significance of interactions between microplastics and POPs in the marine environment: A critical overview , 2019, TrAC Trends in Analytical Chemistry.

[2]  Richard C. Thompson,et al.  Enhanced desorption of persistent organic pollutants from microplastics under simulated physiological conditions. , 2014, Environmental pollution.

[3]  S. Valiyaveettil,et al.  Fate of Nanoplastics in Marine Larvae: A Case Study Using Barnacles, Amphibalanus amphitrite , 2018 .

[4]  H. Bouwmeester,et al.  Presence and risks of nanosilica in food products , 2011, Nanotoxicology.

[5]  Z. Zhong,et al.  Small, Traceable, Endosome-Disrupting, and Bioresponsive Click Nanogels Fabricated via Microfluidics for CD44-Targeted Cytoplasmic Delivery of Therapeutic Proteins. , 2019, ACS applied materials & interfaces.

[6]  Hao Zhou,et al.  Combined effect of polystyrene microplastics and dibutyl phthalate on the microalgae Chlorella pyrenoidosa. , 2019, Environmental pollution.

[7]  Bing Wu,et al.  Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells. , 2019, Chemosphere.

[8]  Juan Wang,et al.  Sorption behaviors of phenanthrene, nitrobenzene, and naphthalene on mesoplastics and microplastics , 2019, Environmental Science and Pollution Research.

[9]  M. Lodovici,et al.  Oxidative Stress and Air Pollution Exposure , 2011, Journal of toxicology.

[10]  Chiu‐Wen Chen,et al.  Polystyrene microplastic particles: In vitro pulmonary toxicity assessment. , 2019, Journal of hazardous materials.

[11]  Rozhin Penjweini,et al.  Intracellular dynamics and fate of polystyrene nanoparticles in A549 Lung epithelial cells monitored by image (cross-) correlation spectroscopy and single particle tracking. , 2015, Biochimica et biophysica acta.

[12]  R. Marcos,et al.  Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells , 2020 .

[13]  Colin R. Janssen,et al.  Microplastic as a Vector for Chemicals in the Aquatic Environment: Critical Review and Model-Supported Reinterpretation of Empirical Studies , 2016, Environmental science & technology.

[14]  N. Benson,et al.  Occurrence and distribution of microplastics-sorbed phthalic acid esters (PAEs) in coastal psammitic sediments of tropical Atlantic Ocean, Gulf of Guinea. , 2020, The Science of the total environment.

[15]  J. Prunier,et al.  Ecotoxicity of polyethylene nanoplastics from the North Atlantic oceanic gyre on freshwater and marine organisms (microalgae and filter-feeding bivalves) , 2019, Environmental Science and Pollution Research.

[16]  C. Stefanadis,et al.  Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases. , 2008, Atherosclerosis.

[17]  Nanna B. Hartmann,et al.  The toxicity of plastic nanoparticles to green algae as influenced by surface modification, medium hardness and cellular adsorption. , 2017, Aquatic toxicology.

[18]  C. Duan,et al.  Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells. , 2020, Chemosphere.

[19]  Shaoyu Zhou,et al.  Oxidative stress and oxidative damage in chemical carcinogenesis. , 2011, Toxicology and applied pharmacology.

[20]  Julia Gorelik,et al.  Respiratory epithelial cytotoxicity and membrane damage (holes) caused by amine-modified nanoparticles , 2012, Nanotoxicology.

[21]  F. G. Silva,et al.  Nanopolystyrene particles at environmentally relevant concentrations causes behavioral and biochemical changes in juvenile grass carp (Ctenopharyngodon idella). , 2021, Journal of hazardous materials.

[22]  Chen Fp,et al.  Lower concentrations of phthalates induce proliferation in human breast cancer cells , 2014 .

[23]  P. Geraldine,et al.  Protective role of chrysin against oxidative stress in d‐galactose‐induced aging in an experimental rat model , 2012, Geriatrics & gerontology international.

[24]  T. Pieber,et al.  Nano-sized and micro-sized polystyrene particles affect phagocyte function , 2013, Cell Biology and Toxicology.

[25]  G. Zeng,et al.  Recent advances in toxicological research of nanoplastics in the environment: A review. , 2019, Environmental pollution.

[26]  Lijing Liu,et al.  Sorption of polycyclic aromatic hydrocarbons to polystyrene nanoplastic , 2016, Environmental toxicology and chemistry.

[27]  K. Dawson,et al.  Accumulation and embryotoxicity of polystyrene nanoparticles at early stage of development of sea urchin embryos Paracentrotus lividus. , 2014, Environmental science & technology.

[28]  M. Clara,et al.  Occurrence of phthalates in surface runoff, untreated and treated wastewater and fate during wastewater treatment. , 2010, Chemosphere.

[29]  R. Ge,et al.  Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation. , 2012, Toxicology in vitro : an international journal published in association with BIBRA.

[30]  M. Tokuda,et al.  Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate. , 2002, The Biochemical journal.

[31]  Juan Zheng,et al.  Quantification of the combined toxic effect of polychlorinated biphenyls and nano-sized polystyrene on Daphnia magna. , 2019, Journal of hazardous materials.

[32]  Monty Liong,et al.  Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. , 2008, ACS nano.

[33]  W. Koerdel,et al.  Occurrence and fate of phthalates in soil and plants , 1993 .

[34]  Zhiquan Liu,et al.  Transcriptional response provides insights into the effect of chronic polystyrene nanoplastic exposure on Daphnia pulex. , 2019, Chemosphere.

[35]  E. Wouters,et al.  ROS in the local and systemic pathogenesis of COPD. , 2003, Free radical biology & medicine.

[36]  R. D. Di Giulio,et al.  Nanoplastics Decrease the Toxicity of a Complex PAH Mixture but Impair Mitochondrial Energy Production in Developing Zebrafish. , 2019, Environmental science & technology.

[37]  Xuetao Guo,et al.  High temperature depended on the ageing mechanism of microplastics under different environmental conditions and its effect on the distribution of organic pollutants. , 2020, Water research.

[38]  F. G. Silva,et al.  Effects of polystyrene nanoplastics on Ctenopharyngodon idella (grass carp) after individual and combined exposure with zinc oxide nanoparticles. , 2021, Journal of hazardous materials.

[39]  M. Ahamed,et al.  Oxidative stress mediated cytotoxicity and apoptosis response of bismuth oxide (Bi2O3) nanoparticles in human breast cancer (MCF-7) cells. , 2019, Chemosphere.

[40]  Y. Hu,et al.  Aggregation kinetics of UV irradiated nanoplastics in aquatic environments. , 2019, Water research.

[41]  T Kaminuma,et al.  Plastic resin pellets as a transport medium for toxic chemicals in the marine environment. , 2001, Environmental science & technology.

[42]  R. Liu,et al.  Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing. , 2019, Acta biomaterialia.

[43]  V. Laforgia,et al.  Polystyrene nanoparticles internalization in human gastric adenocarcinoma cells. , 2016, Toxicology in vitro : an international journal published in association with BIBRA.

[44]  David M. Brown,et al.  Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. , 2001, Toxicology and applied pharmacology.

[45]  T. Rocha-Santos,et al.  Environmental exposure to microplastics: An overview on possible human health effects. , 2019, The Science of the total environment.

[46]  D. Barceló,et al.  Cytotoxic effects of commonly used nanomaterials and microplastics on cerebral and epithelial human cells , 2017, Environmental research.

[47]  Qian Wu,et al.  Occurrence and fate of endogenous steroid hormones, alkylphenol ethoxylates, bisphenol A and phthalates in municipal sewage treatment systems. , 2017, Journal of environmental sciences.

[48]  K. Qu,et al.  Toxicities of polystyrene nano- and microplastics toward marine bacterium Halomonas alkaliphila. , 2018, The Science of the total environment.

[49]  Hao Zhou,et al.  Acute and chronic combined effect of polystyrene microplastics and dibutyl phthalate on the marine copepod Tigriopus japonicus. , 2020, Chemosphere.

[50]  H. Hassan,et al.  Di-(2-ethylhexyl) Phthalate, a major bioactive metabolite with antimicrobial and cytotoxic activity isolated from River Nile derived fungus Aspergillus awamori , 2018, Beni-Suef University Journal of Basic and Applied Sciences.

[51]  B. Bay,et al.  Targeted metabolomics reveals differential biological effects of nanoplastics and nanoZnO in human lung cells , 2019, Nanotoxicology.

[52]  Q. Wang,et al.  Discovery of 6-(2-(dimethylamino)ethyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine as a highly potent cyclin-dependent kinase 4/6 inhibitor for treatment of cancer. , 2019, European journal of medicinal chemistry.

[53]  M. Blanchard,et al.  Atmospheric fate of phthalate esters in an urban area (Paris-France). , 2006, The Science of the total environment.

[54]  G. Grassi,et al.  Comparative ecotoxicity of polystyrene nanoparticles in natural seawater and reconstituted seawater using the rotifer Brachionus plicatilis. , 2017, Ecotoxicology and environmental safety.

[55]  Yan Zhang,et al.  Influence of microplastics on the accumulation and chronic toxic effects of cadmium in zebrafish (Danio rerio). , 2018, Chemosphere.

[56]  Ellen Besseling,et al.  Effects of microplastic on fitness and PCB bioaccumulation by the lugworm Arenicola marina (L.). , 2013, Environmental science & technology.

[57]  I. Sayeed,et al.  Biomarkers of oxidative stress: a comparative study of river Yamuna fish Wallago attu (Bl. & Schn.). , 2003, The Science of the total environment.

[58]  G. Bhagwat,et al.  Interaction of chemical contaminants with microplastics: Principles and perspectives. , 2019, The Science of the total environment.

[59]  A. Booth,et al.  Sorption of PAHs to microplastic and their bioavailability and toxicity to marine copepods under co-exposure conditions. , 2019, Environmental pollution.

[60]  Hans Bouwmeester,et al.  Potential Health Impact of Environmentally Released Micro- and Nanoplastics in the Human Food Production Chain: Experiences from Nanotoxicology. , 2015, Environmental science & technology.

[61]  G. Malafaia,et al.  Behavioral and biochemical consequences of Danio rerio larvae exposure to polylactic acid bioplastic. , 2020, Journal of hazardous materials.

[62]  Yunchao Su,et al.  Reactive Oxygen Species-Dependent Calpain Activation Contributes to Airway and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease. , 2019, Antioxidants & redox signaling.

[63]  Xiaomei Yang,et al.  Aging mechanism of microplastics with UV irradiation and its effects on the adsorption of heavy metals. , 2020, Journal of hazardous materials.

[64]  Zhengguo Song,et al.  Effects of polyethylene microplastic on the phytotoxicity of di-n-butyl phthalate in lettuce (Lactuca sativa L. var. ramosa Hort). , 2019, Chemosphere.

[65]  W. MacNee,et al.  Oxidative stress and lung inflammation in airways disease. , 2001, European journal of pharmacology.

[66]  Xuanhe Fu,et al.  Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell. , 2019, The Science of the total environment.

[67]  Pakatip Ruenraroengsak,et al.  Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells , 2015, Particle and Fibre Toxicology.

[68]  K. Barišić,et al.  The effect of liposomes with superoxide dismutase on A2182 cells. , 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[69]  J. Giesy,et al.  Aryl hydrocarbon receptor-mediated potencies in field-deployed plastics vary by type of polymer , 2019, Environmental Science and Pollution Research.

[70]  S. Colafarina,et al.  In Vitro Genotoxicity of Polystyrene Nanoparticles on the Human Fibroblast Hs27 Cell Line , 2019, Nanomaterials.

[71]  J. Gaspéri,et al.  A first overview of textile fibers, including microplastics, in indoor and outdoor environments. , 2017, Environmental pollution.

[72]  Jing Zhang,et al.  Interaction of chromium(III) or chromium(VI) with catalase and its effect on the structure and function of catalase: An in vitro study. , 2018, Food chemistry.

[73]  Fei-fei Liu,et al.  Interactions between microplastics and phthalate esters as affected by microplastics characteristics and solution chemistry. , 2019, Chemosphere.

[74]  N. F. D. de Melo,et al.  How much are microplastics harmful to the health of amphibians? A study with pristine polyethylene microplastics and Physalaemus cuvieri. , 2020, Journal of hazardous materials.

[75]  C. Weder,et al.  Emergence of Nanoplastic in the Environment and Possible Impact on Human Health. , 2019, Environmental science & technology.

[76]  V. Kočí,et al.  Partitioning of chemical contaminants to microplastics: Sorption mechanisms, environmental distribution and effects on toxicity and bioaccumulation. , 2019, Environmental pollution.

[77]  A. Favier,et al.  Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells. , 2010, Free radical biology & medicine.

[78]  F. G. Silva,et al.  Toxicity of polystyrene nanoplastics in Ctenopharyngodon idella juveniles: A genotoxic, mutagenic and cytotoxic perspective. , 2021, The Science of the total environment.

[79]  W. Roberts,et al.  Superoxide release from contracting skeletal muscle in pulmonary TNF-α overexpression mice. , 2014, American journal of physiology. Regulatory, integrative and comparative physiology.

[80]  H. Hou,et al.  Combined cytotoxicity of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells. , 2019, Environmental pollution.

[81]  H. Karapanagioti,et al.  Micro(nanoplastics) in the marine environment: Current knowledge and gaps , 2018 .

[82]  P. Jani,et al.  Inflammatory mechanisms in the lung , 2008, Journal of inflammation research.

[83]  R. Meschini,et al.  In vitro evaluation of cytotoxic and genotoxic effects of Di(2-ethylhexyl)-phthalate (DEHP) on European sea bass (Dicentrarchus labrax) embryonic cell line. , 2019, Toxicology in vitro : an international journal published in association with BIBRA.

[84]  Peng Liu,et al.  Effect of aging on adsorption behavior of polystyrene microplastics for pharmaceuticals: Adsorption mechanism and role of aging intermediates. , 2020, Journal of hazardous materials.

[85]  M. J. Hazen,et al.  Endoplasmic reticulum stress as a novel cellular response to di (2-ethylhexyl) phthalate exposure. , 2015, Toxicology in vitro : an international journal published in association with BIBRA.

[86]  E. Faustman,et al.  Improving in vitro Sertoli cell/gonocyte co-culture model for assessing male reproductive toxicity: Lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates. , 2009, Toxicology and applied pharmacology.

[87]  Y. An,et al.  Effects of micro- and nanoplastics on aquatic ecosystems: Current research trends and perspectives. , 2017, Marine pollution bulletin.

[88]  T. Xia,et al.  Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress. , 2015, Nanoscale.

[89]  Qixing Zhou,et al.  Exposure to PbSe Nanoparticles and Male Reproductive Damages in a Rat Model. , 2019, Environmental science & technology.

[90]  Amanda Pereira da Costa Araújo,et al.  Microplastic ingestion induces behavioral disorders in mice: A preliminary study on the trophic transfer effects via tadpoles and fish. , 2020, Journal of hazardous materials.

[91]  T. Hayat,et al.  Impact of water chemistry on surface charge and aggregation of polystyrene microspheres suspensions. , 2018, The Science of the total environment.

[92]  S. Lacorte,et al.  Comparative toxicity, oxidative stress and endocrine disruption potential of plasticizers in JEG-3 human placental cells. , 2017, Toxicology in vitro : an international journal published in association with BIBRA.

[93]  W. Zhu,et al.  Interactive effects of polystyrene microplastics and roxithromycin on bioaccumulation and biochemical status in the freshwater fish red tilapia (Oreochromis niloticus). , 2019, The Science of the total environment.

[94]  M. Vijver,et al.  Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish , 2019, Communications Biology.

[95]  Richard C. Thompson,et al.  The physical impacts of microplastics on marine organisms: a review. , 2013, Environmental pollution.

[96]  E. Fröhlich,et al.  Intracellular calcium levels as screening tool for nanoparticle toxicity , 2015, Journal of applied toxicology : JAT.

[97]  Y. An,et al.  Polystyrene nanoplastics inhibit reproduction and induce abnormal embryonic development in the freshwater crustacean Daphnia galeata , 2017, Scientific Reports.

[98]  I. Shin,et al.  Toxicological assessment of phthalates and their alternatives using human keratinocytes. , 2019, Environmental research.

[99]  T. Kögel,et al.  Micro- and nanoplastic toxicity on aquatic life: Determining factors. , 2019, The Science of the total environment.

[100]  Caiying Zhang,et al.  Molybdenum and cadmium co-induce oxidative stress and apoptosis through mitochondria-mediated pathway in duck renal tubular epithelial cells. , 2020, Journal of hazardous materials.