Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

In vitro, actin filament tension correlates with the binding and apparent activity of the filament-severing protein cofilin, suggesting a molecular mechanism by which cells respond to changes in mechanical force.

[1]  Willy Wriggers,et al.  Actin Depolymerizing Factor Stabilizes an Existing State of F-Actin and Can Change the Tilt of F-Actin Subunits , 2001, The Journal of cell biology.

[2]  L. Blanchoin,et al.  Cofilin increases the bending flexibility of actin filaments: implications for severing and cell mechanics. , 2008, Journal of molecular biology.

[3]  T. Obinata,et al.  Low molecular-weight G-actin binding proteins involved in the regulation of actin assembly during myofibrillogenesis. , 1997, Cell structure and function.

[4]  Yasuhiro Sawada,et al.  Activation of a signaling cascade by cytoskeleton stretch. , 2004, Developmental cell.

[5]  Michael P. Sheetz,et al.  Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas , 2006, Cell.

[6]  H. Tatsumi,et al.  Growth cones exhibit enhanced cell–cell adhesion after neurotransmitter release , 1999, Neuroscience.

[7]  A. Hall,et al.  Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins , 1997, The Journal of cell biology.

[8]  T. Andreassen,et al.  The effect of mechanical stress on healing skin wounds: an experimental study in rabbits using tissue expansion. , 1991, British journal of plastic surgery.

[9]  M. Sato,et al.  Cyclic Force Applied to FAs Induces Actin Recruitment Depending on the Dynamic Loading Pattern , 2010, The open biomedical engineering journal.

[10]  Wah Chiu,et al.  Cofilin Changes the Twist of F-Actin: Implications for Actin Filament Dynamics and Cellular Function , 1997, The Journal of cell biology.

[11]  J. Bamburg,et al.  Putting a new twist on actin: ADF/cofilins modulate actin dynamics. , 1999, Trends in cell biology.

[12]  T. Yanagida,et al.  Torsional rigidity of single actin filaments and actin-actin bond breaking force under torsion measured directly by in vitro micromanipulation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[13]  G. Voth,et al.  Actin filament remodeling by actin depolymerization factor/cofilin , 2010, Proceedings of the National Academy of Sciences.

[14]  K. Hayakawa,et al.  Dynamic reorientation of cultured cells and stress fibers under mechanical stress from periodic stretching. , 2001, Experimental cell research.

[15]  T. Adachi,et al.  Effect of tensile force on the mechanical behavior of actin filaments. , 2011, Journal of biomechanics.

[16]  A. Ashkin,et al.  Optical trapping and manipulation of single cells using infrared laser beams , 1987, Nature.

[17]  E. Nishida,et al.  Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization , 1998, Nature.

[18]  C. S. Chen,et al.  Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[19]  S. V. Perry,et al.  [94] Myosin adenosinetriphosphatase: ATP H2O→ADP+H3PO4 , 1955 .

[20]  J. Cooper,et al.  Actin filament severing by cofilin. , 2007, Journal of molecular biology.

[21]  H. Mellor,et al.  Actin stress fibres , 2007, Journal of Cell Science.

[22]  W. Cao,et al.  Energetics and kinetics of cooperative cofilin-actin filament interactions. , 2006, Journal of molecular biology.

[23]  J. Bamburg.  Proteins of the ADF/cofilin family: essential regulators of actin dynamics. , 1999, Annual review of cell and developmental biology.

[24]  M. Sokabe,et al.  Force- and Ca2+-dependent internalization of integrins in cultured endothelial cells , 2011, Journal of Cell Science.

[25]  E. Nishida,et al.  Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides. , 1990, The Journal of biological chemistry.

[26]  L. Blanchoin,et al.  Actin-Filament Stochastic Dynamics Mediated by ADF/Cofilin , 2007, Current Biology.

[27]  E. M. De La Cruz.  Cofilin binding to muscle and non-muscle actin filaments: isoform-dependent cooperative interactions. , 2005, Journal of molecular biology.

[28]  Donald E. Ingber,et al.  Electromagnetic needles with submicron pole tip radii for nanomanipulation of biomolecules and living cells , 2004 .

[29]  Pierre Gönczy,et al.  Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos , 2003, Science.

[30]  Dylan T Burnette,et al.  Myosin II functions in actin-bundle turnover in neuronal growth cones , 2006, Nature Cell Biology.

[31]  Tom Shemesh,et al.  Assembly and mechanosensory function of focal adhesions: experiments and models. , 2006, European journal of cell biology.

[32]  Y Ueno,et al.  X-ray diffraction evidence for the extensibility of actin and myosin filaments during muscle contraction. , 1994, Biophysical journal.

[33]  B. Sumpio,et al.  Morphological response of human endothelial cells subjected to cyclic strain in vitro. , 1991, Microvascular research.

[34]  D E Ingber,et al.  Mechanotransduction across the cell surface and through the cytoskeleton. , 1993, Science.

[35]  J. Spudich,et al.  The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. , 1971, The Journal of biological chemistry.

[36]  T. Obinata,et al.  Stimulus-dependent disorganization of actin filaments induced by overexpression of cofilin in C2 myoblasts. , 1996, Cell structure and function.

[37]  E. Andrianantoandro,et al.  Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. , 2006, Molecular cell.

[38]  David D. Thomas,et al.  Cofilin increases the torsional flexibility and dynamics of actin filaments. , 2005, Journal of molecular biology.

[39]  C. S. Chen,et al.  Geometric control of cell life and death. , 1997, Science.

[40]  Michael P. Sheetz,et al.  Force transduction by Triton cytoskeletons , 2002, The Journal of cell biology.

[41]  L. Lanyon,et al.  Mechanical Strain Stimulates Osteoblast Proliferation Through the Estrogen Receptor in Males as Well as Females , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  D. DeRosier,et al.  Image analysis shows that variations in actin crossover spacings are random, not compensatory. , 1992, Biophysical journal.

[43]  D. Drubin,et al.  Cofilin recruitment and function during actin-mediated endocytosis dictated by actin nucleotide state , 2007, The Journal of cell biology.

[44]  Peter G. Gillespie,et al.  Molecular basis of mechanosensory transduction , 2001, Nature.

[45]  H E Huxley,et al.  The low-angle x-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor. , 1967, Journal of molecular biology.

[46]  K. Kaibuchi,et al.  Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts. , 2001, American journal of physiology. Cell physiology.

[47]  T. Obinata,et al.  Effects of cofilin on actin filamentous structures in cultured muscle cells. Intracellular regulation of cofilin action. , 1995, Journal of cell science.

[48]  Shin'ichi Ishiwata,et al.  Mechanical distortion of single actin filaments induced by external force: detection by fluorescence imaging. , 2009, Biophysical journal.