Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp

[1]  C. Berne,et al.  Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men. , 2004, Diabetes care.

[2]  L. Råstam,et al.  Comparison of different procedures to identify probable cases of myocardial infarction and stroke in two Swedish prospective cohort studies using local and national routine registers , 2000, European Journal of Epidemiology.

[3]  P. Jehle,et al.  High affinity binding sites for proinsulin in human IM-9 lymphoblasts , 1996, Diabetologia.

[4]  G. Reaven,et al.  Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease , 1994, Diabetologia.

[5]  B. Howard,et al.  Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic american indians: the Strong Heart Study. , 2003, Diabetes care.

[6]  J. Yudkin.  Increased proinsulin concentrations and excess risk of coronary heart disease in patients with diabetes and prediabetes. , 2002, Circulation.

[7]  S. Haffner,et al.  Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. , 2002, Diabetes care.

[8]  Peter Libby,et al.  Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. , 2002, JAMA.

[9]  C. Berne,et al.  Proinsulin Is an Independent Predictor of Coronary Heart Disease: Report From a 27-Year Follow-Up Study , 2002, Circulation.

[10]  E. Barrett-Connor,et al.  Sex Differences in the Association Between Proinsulin and Intact Insulin With Coronary Heart Disease in Nondiabetic Older Adults: The Rancho Bernardo Study , 2002, Circulation.

[11]  P. Elwood,et al.  Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly Study , 2002, Diabetologia.

[12]  N. Wareham,et al.  Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk) , 2001, BMJ : British Medical Journal.

[13]  BirgittaStegmayr,et al.  High Proinsulin Levels Precede First-Ever Stroke in a Nondiabetic Population , 2000 .

[14]  P. Grant,et al.  Plasminogen-activator inhibitor type 1 and coronary artery disease. , 2000, The New England journal of medicine.

[15]  P. McKeigue,et al.  Birth weight and the insulin resistance syndrome: association of low birth weight with truncal obesity and raised plasminogen activator inhibitor-1 but not with abdominal obesity or plasma lipid disturbances , 2000, Diabetologia.

[16]  R. Holman,et al.  Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47). , 1999, American heart journal.

[17]  G. Hallmans,et al.  High proinsulin concentration precedes acute myocardial infarction in a nondiabetic population. , 1999, Metabolism: clinical and experimental.

[18]  S. Haffner,et al.  Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS). , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[19]  S. Yusuf,et al.  The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. , 1999, Diabetes care.

[20]  M. Laakso,et al.  Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. , 1998, Circulation.

[21]  R. Bergman,et al.  Proinsulin and insulin concentrations in relation to carotid wall thickness: Insulin Resistance Atherosclerosis Study. , 1998, Stroke.

[22]  P. Zimmet,et al.  Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[23]  L. Bouter,et al.  Insulin and risk of cardiovascular disease: a meta-analysis. , 1998, Circulation.

[24]  T. Lakka,et al.  Hyperinsulinemia Is Associated With the Incidence of Hypertension and Dyslipidemia in Middle-Aged Men , 1998, Diabetes.

[25]  G. Boden.  Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM , 1997, Diabetes.

[26]  R. Stout.  Hyperinsulinemia and Atherosclerosis , 1996, Diabetes.

[27]  A. Baron,et al.  Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. , 1996, The Journal of clinical investigation.

[28]  R. Bergman,et al.  Insulin Sensitivity and Atherosclerosis , 1996 .

[29]  G. Dagenais,et al.  Hyperinsulinemia as an independent risk factor for ischemic heart disease. , 1996, The New England journal of medicine.

[30]  R. Bergman,et al.  Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators. , 1996, Circulation.

[31]  R. Bergman,et al.  The insulin resistance atherosclerosis study (IRAS) objectives, design, and recruitment results. , 1995, Annals of epidemiology.

[32]  A. Hamsten,et al.  Insulin, intact and split proinsulin, and coronary artery disease in young men. , 1995, Circulation.

[33]  E. Barrett-Connor,et al.  Is Insulin Really a Heart Disease Risk Factor? , 1995, Diabetes Care.

[34]  M. Laakso,et al.  NIDDM and Its Metabolic Control Predict Coronary Heart Disease in Elderly Subjects , 1994, Diabetes.

[35]  H. Tunstall-Pedoe,et al.  Myocardial Infarction and Coronary Deaths in the World Health Organization MONICA Project: Registration Procedures, Event Rates, and Case‐Fatality Rates in 38 Populations From 21 Countries in Four Continents , 1994, Circulation.

[36]  B. Sobel,et al.  Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin. A potential risk factor for vascular disease. , 1994, Circulation.

[37]  M. Laakso,et al.  How good a marker is insulin level for insulin resistance? , 1993, American journal of epidemiology.

[38]  D. Howey,et al.  Biosynthetic Human Proinsulin: Review of Chemistry, in Vitro and in Vivo Receptor Binding, Animal and Human Pharmacology Studies, and Clinical Trial Experience , 1992, Diabetes Care.

[39]  D. Owens,et al.  Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. , 1989, The Biochemical journal.

[40]  D. Owens,et al.  INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES , 1989, The Lancet.

[41]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.

[42]  G. Ronquist,et al.  On the availability of certain metabolites at the outer surface of normal and malignant cells for the membranous de novo synthesis of ATP and other nucleotides. , 1975, Upsala journal of medical sciences.

[43]  H. Hedstrand.  A study of middle-aged men with particular reference to risk factors for cardiovascular disease. , 1975, Upsala journal of medical sciences. Supplement.